项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Darusentan, HMR-4005, LU-135252

达芦生坦Chemical Name: (+)-2(S)-(4,6-Dimethoxypyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropionic acid
CAS No. 171714-84-4
项目整合开发状态: Phase II
项目研究机构: Abbott (Originator), Myogen (Originator), Aven...
参考文献标题:New carboxylic acid derivs.,their preparation and their use
文献作者:Riechers,H.; Klinge,D.; Amberg,W.; Kling,A.; M黮ler,S.; Baumann,E.; Rheinheimer,J.; Vogelbacher,U.J.; Wernet,W.; Unger,L.; Raschack,M.(BASF AG)
参考来源:EP 0785926; JP 1998507190; WO 9611914

Dacinostat, NVP-LAQ-824, LAQ-824

达诺司他Chemical Name: 3-[4-[N-(2-Hydroxyethyl)-N-[2-(1H-indol-3-yl)ethyl]aminomethyl]phenyl]-2(E)-propenohydroxamic acid
CAS No. 404951-53-7
项目整合开发状态: Phase I
项目研究机构: Novartis (Originator)
合成...
参考文献标题:Deacetylase inhibitors
文献作者:Bair,K.W.; Versace,R.W.; Green,M.A.; Remiszewski,S.W.; Perez,L.B.; Sambucetti,L.; Sharma,S.K.(Novartis AG; Novartis-Erfindungen VmbH)
参考来源:WO 0222577

Naxaprostene, CG-4305

那前列烯 11-(环戊-2-烯基)十一烷酸 Chemical Name: [2E,3aalpha,4alpha(1E,3R*),5beta,6aalpha]-3-[[4-(3-Cyclohexyl-3-hydroxy-1-propenyl)hexahydro-5-hydroxy-2(1H)-pentalenylidene]methyl]benzoic acid; [2E,3aS*,4R*(1E,3...
参考文献标题:New cis-bicyclo[3.3.0]octane derivs.,medicines containing them and processes for the preparation of these compds.and medicines
文献作者:B鰄lke,H.; Loschen,G.; Michel,G.; M黮ler,B.(Gr黱enthal GmbH)
参考来源:DE 3146278

Z-360

那托西派Chemical Name: Bis[3-[3-[5-Cyclohexyl-1-(3,3-dimethyl-2-oxobutyl)-2-oxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3(R)-yl]ureido]benzoic acid] calcium salt
CAS No. 209219-38-5 (free acid), 209219...
参考文献标题:1,5-Benzodiazepine derivs.
文献作者:Murata,M.; Shinozaki,K.; Yoneta,T.; Miura,N.; Maeda,K.(Zeria Pharmaceutical Co.,Ltd.)
参考来源:EP 0945445; US 6239131; WO 9825911

Naratriptan hydrochloride, GG-548, GR-85548A, GR-85548(free base), Amerge, Naramig

那拉曲坦盐酸盐那拉曲坦 Chemical Name: N-Methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide monohydrochloride
CAS No. 143388-64-1, 121679-13-8 (free base), 121679-19-4 (HCl)
项目整合开发状态: Lau...
参考文献标题:Indole derivs
文献作者:Oxford,A.W.; Butina,D.; Owen,M.R.(Glaxo Wellcome plc)
参考来源:AU 8820692; EP 0303507; GB 2208646; JP 1989207288; US 4997841

Nateglinide, DJN-608, SDZ-DJN-608, YM-026, AY-4166, A-4166, Trazec, Fastic, Starlix, Starsis

那格列奈Chemical Name: (-)-N-(trans-4-Isopropylcyclohexyl-1-carbonyl)-D-phenylalanine
CAS No. 105816-04-4
项目整合开发状态: Launched-1999
项目研究机构: Ajinomoto (Originator), Aventis Pharma (Marketer), Novart...
参考文献标题:Hypoglycemic agent
文献作者:Toyoshima,S.; Seto,Y.; Shinkai,H.; Toi,K.; Kumashiro,I.(Ajinomoto Co.,Inc.)
参考来源:EP 0196222; US 4816484

Nadifloxacin, OPC-7251, Nadixa, Nadoxin, Acuatim

那氟沙星 9-氟-6,7-二氢-8-(4-羟基-1-哌啶基)-5-甲基-1-氧基-1H,5H-苯并[ij]喹喹喹啶-2-羧酸 8-氟-5,6-二氢-7-(4-羟基哌啶)-4-甲基-1-氧-4H-3a-氮-1H-苯甲苯-2-羧酸钠盐Chemical Name: (?-9-Fluoro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-6,7-dihydro-1H,...
参考文献标题:Antibacterial agents
文献作者:Kano,M.; Nakagawa,K.; Ishikawa,H.; Uno,T.(Otsuka Pharmaceutical Co.,Ltd.)
参考来源:JP 1983090511

Nafazatrom, Bay-g-6575

那法扎琼Chemical Name: 2,4-Dihydro-5-methyl-2-[2-(2-naphthalenyloxy)ethyl]-3H-pyrazol-3-one
CAS No. 59040-30-1
项目整合开发状态: Biological Testing
项目研究机构: Bayer (Originator)
合成路线:Compound can be prep...
参考文献标题:BAY-g-6575
文献作者:Prous,J.R.; Hillier,K.
参考来源:Drugs Fut 1979,4(6),396

Trioxifene mesylate(Rec INNM, USAN), Cpd-133314, Lilly-88571(free base), LY-133314

那洛西芬曲沃昔芬 Chemical Name: 3,4-Dihydro-2-(p-methoxyphenyl)-1-naphthyl p-[2-(1-pyrrolidinyl)ethoxy]phenyl ketone methanesulfonate; [3,4-Dihydro-2-(4-methoxyphenyl)-1-naphthalenyl][4-[2-(1-pyrrolidinyl)et...
参考文献标题:Trioxifene mesylate
文献作者:Castar,J.; Hillier,K.
参考来源:Drugs Fut 1980,5(5),259

Namirotene, CBS-211A

那米罗汀Chemical Name: (E)-4-[2-(2-Isopropyl-5-thienyl)propenyl]benzoic acid
CAS No. 101506-83-6
项目整合开发状态: Phase I
项目研究机构: Chauvin (Originator)
合成路线:The addition of methyl magnesium iodide to ...
参考文献标题:New derivatives of 4-vinyl benzoic acid,process for their preparation and their uses in therapeutics ans as ligands
文献作者:Coquelet,C.; Roussillon,S.; Sincholle,D.; Bonne,C.; Alazet,A.(Chauvin Laboratories SA)
参考来源:EP 0161156; FR 8405531; US 4929635; WO 8504652