Nafazatrom, Bay-g-6575
那法扎琼Chemical Name: 2,4-Dihydro-5-methyl-2-[2-(2-naphthalenyloxy)ethyl]-3H-pyrazol-3-one
CAS No. 59040-30-1
项目整合开发状态: Biological Testing
项目研究机构: Bayer (Originator)
合成路线:Compound can be prepared in three different ways:1) By cyclization of 2-(2-naphthyloxy)ethylhydrazine (I) with ethyl acetoacetate (II) in refluxing ethanol.2) By cyclization of 2-(2-naphthyloxy)ethylhydrazine (I) with tetrolic acid ethyl ester (III) in refluxing n-butanol.3) By condensation of 3-methylpyrazol-5-one (IV) with 2-(2-naphthyloxy)ethyl bromide (V) by means of NaH in DMF or by heating at 110 C.
📌 参考资料/链接：
参考文献标题:BAY-g-6575
文献作者:Prous,J.R.; Hillier,K.
参考来源:Drugs Fut 1979,4(6),396
📄 详细内容
合成路线:Compound can be prepared in three different ways:1) By cyclization of 2-(2-naphthyloxy)ethylhydrazine (I) with ethyl acetoacetate (II) in refluxing ethanol.2) By cyclization of 2-(2-naphthyloxy)ethylhydrazine (I) with tetrolic acid ethyl ester (III) in refluxing n-butanol.3) By condensation of 3-methylpyrazol-5-one (IV) with 2-(2-naphthyloxy)ethyl bromide (V) by means of NaH in DMF or by heating at 110 C.
参考文献标题:
文献作者:Moeller,E.; et al.
参考来源:US 4113957
产品链接: CAS No. 59040-30-1››