项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Fosmidomycin, FR-31564

膦胺霉素Chemical Name: 3-(N-Formyl-N-hydroxyamino)propylphosphonic acid; [3-(Formylhydroxyamino)propyl]phosphonic acid
CAS No. 66508-53-0, 66508-65-4 (Ca salt (1:1)), 66508-51-8 (Ca salt (2:1)), 66508-...
参考文献标题:FR-31564
文献作者:Prous,J.R.; Castar,J.
参考来源:Drugs Fut 1980,5(5),239

Sertindole, S-1991, Lu-23-174(maleate), Serdolect, Serlect

舍吲哚Chemical Name: 5-Chloro-1-(4-fluorophenyl)-3-[1-(2-oxoimidazolidin-1-ylethyl)piperidin-4-yl]-1H-indole; 1-[2-[4-[5-Chloro-1-(4-fluorophenyl)-1H-indol-3-yl]piperidin-1-yl]ethyl]imidazolidin-2-one 参考文献标题:Heterocyclic cpds.
文献作者:Perregaard,J.K.(H.Lundbeck A/S)
参考来源:AU 8655901; EP 0200322; ES 8707499; JP 1986236764; US 4710500

Sertraline, CP-51974-1, CP-5197401(hydrochloride)

舍曲林盐酸舍曲林 Chemical Name: (1S-cis)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine; (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthylamine
CAS No. 79617-96-2...
参考文献标题:Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphtalenamine
文献作者:Kraska,A.R.; Welch,W.M.Jr.; Koe,B.K.; Harbert,C.A.(Pfizer Inc.)
参考来源:EP 0030081; JP 1981086137; US 4536518

Sufugolix, TAK-013

舒夫戈利Chemical Name: N-[4-[5-(N-Benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl]-N'-methoxyurea
CAS No. 308831-61-0, 308831-...
参考文献标题:Thienopyrimidine cpds.,their production and use
文献作者:Suzuki,N.; Furuya,S.; Choh,N.; Nara,Y.(Takeda Chemical Industries,Ltd.)
参考来源:EP 1163244; JP 2001278884; JP 2001278885; US 6340682; WO 0056739

Sultopride, Barnotil, Barnetil

舒托必利Chemical Name: N-[(1-Methyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide
CAS No. 53583-79-2
项目整合开发状态: Launched-1976
项目研究机构: Sanofi-Aventis (Originator)
合成路线:Prepared by ...
参考文献标题:Sultopride
文献作者:Neuman,M.; Castar,J.; Prous,J.R.
参考来源:Drugs Fut 1976,1(2),83

Suramin sodium, NF-060, CI-1003, NSC-34936, Germanin, Moranyl, Antrypol, Metaret

舒拉明钠 8-[[4-甲基-3-[[3-[[3-[[2-甲基-5-[(4,6,8-三磺基萘-1-基)氨基甲酰]苯基]氨基甲酰]苯基]氨基甲酰氨基]苯甲酰基]氨基]苯甲酰基]氨基]萘-1,3,5-三磺酸 Chemical Name: 8,8'-[Ureylenebis[m-phenylenecarbonylimino(4-methyl-m-phenylene)carbonylimino]]di(1,...
参考文献标题:Suramin Sodium
文献作者:Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1986,11(10),860

Suproclone(Rec INN, USAN), 37162-RP, RP-37162

舒普罗酮Chemical Name: 4-(1-Oxopropyl)-1-piperazinecarboxylic acid (?-6-(7-chloro-1,8-naphthyridin-2-yl)-2,3,6,7-tetrahydro-7-oxo-5H-1,4-dithiino[2,3-c]pyrrol-5-yl ester; 4-Propionyl-1-piperazinecarboxyli...
参考文献标题:Heterocyclic compounds
文献作者:Cotrel,C.; Crisan,C.; Jeanmart,C.; Messer,M.N.(Aventis Pharma SA)
参考来源:BE 0835325; DE 2550111; FR 2313060; FR 2322600; FR 2322601; FR 2322602; GB 1468497; JP 7670776; JP 7733685; JP 7998790; JP 8040671; JP 8051087; US 4220646

ORG-25969

舒更葡糖钠舒更葡糖钠 Chemical Name: 6A,6B,6C,6D,6E,6F,6G,6H-Octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G-octasulfanyl-gamma-cyclodextrin octasodium salt
CAS No. 343306-79-6, 343306-71-8 (free acid)
项...
参考文献标题:6-Mercapto-cyclodextrin derivs.: Reversal agents for drug-induced neuromuscular block
文献作者:Bennet,D.J.; Palin,R.; Zhang,M.(Akzo Nobel N.V.)
参考来源:WO 0140316

Suprofen, TYN-762P(as Poultice), R-25061, Profenal, Suprol, Suprocil, Maldocil

舒洛芬Chemical Name: p-(2-Thenoyl)-hydratropic acid; alpha-Methyl-4-(2-thienylcarbonyl)benzene acetic acid
CAS No. 40828-46-4
项目整合开发状态: Withdrawn-1999
项目研究机构: Cilag (Originator), Janssen (Origin...
参考文献标题:Suprofen
文献作者:Castar,J.; Chatterjee,S.S.
参考来源:Drugs Fut 1976,1(3),148

Suriclone, RP-31264, 31264-RP, Suril

舒立克隆Chemical Name: 4-Methyl-1-piperazinecarboxylic acid 6-(7-chloro-1,8-naphthyridin-2-yl)-2,3,6,7-tetrahydro-7-oxo-5H-1,4-dithiino[2,3-c]pyrrol-5-yl ester; 4-Methyl-1-piperazinecarboxylic acid ester ...
参考文献标题:1,4-Dithiimo[2,3-c]pyrrole derivatives
文献作者:Jeanmart,C.; Leger,A.; Messer,M.N.(Aventis Pharma SA)
参考来源:CA 989841; DE 2360362; FR 2208651; FR 2209129; FR 2258182; GB 1397060; JP 7493392; NL 7316162; US 3948917; US 3966931; ZA 7309139