网站主页>>>项目整合精选>>>项目整合精选>>>Suramin sodium, NF-060, CI-1003, NSC-34936, Germanin, Moranyl, Antrypol, Metaret

Suramin sodium, NF-060, CI-1003, NSC-34936, Germanin, Moranyl, Antrypol, Metaret

舒拉明钠 8-[[4-甲基-3-[[3-[[3-[[2-甲基-5-[(4,6,8-三磺基萘-1-基)氨基甲酰]苯基]氨基甲酰]苯基]氨基甲酰氨基]苯甲酰基]氨基]苯甲酰基]氨基]萘-1,3,5-三磺酸 Chemical Name: 8,8'-[Ureylenebis[m-phenylenecarbonylimino(4-methyl-m-phenylene)carbonylimino]]di(1,3,5-naphthalenetrisulfonic acid) hexasodium salt
CAS No. 129-46-4, 145-63-1 (free acid)
项目整合开发状态: Launched-1940
项目研究机构: Bayer (Originator), National Cancer Institute (Originator), Pfizer (Licensee)
合成路线:Several procedures for obtaining titte compound have been reported:In one method the acylation of 1 naphthylamine 4,6,8-trisulfonic acid trisodium salt (I) with 4 methyl-3-nitrobenzoyt chloride (II) yields the correspond ing amide (III),which is reduced with Fe in acetic acid to the amine (IV).Acylation of (IV) with 3-nitrobenzoyl chloride (V) affords the nitro diamide (VI),which is reduced with Fe and acetic acid before to the amine (VII).Finally,this compound is condensed with phosgene.
📌 参考资料/链接:
参考文献标题:Suramin Sodium
文献作者:Castar,J.; Serradell,M.N.
参考来源:Drugs Fut 1986,11(10),860

📄 详细内容


合成路线:Several procedures for obtaining titte compound have been reported:In one method the acylation of 1 naphthylamine 4,6,8-trisulfonic acid trisodium salt (I) with 4 methyl-3-nitrobenzoyt chloride (II) yields the correspond ing amide (III),which is reduced with Fe in acetic acid to the amine (IV).Acylation of (IV) with 3-nitrobenzoyl chloride (V) affords the nitro diamide (VI),which is reduced with Fe and acetic acid before to the amine (VII).Finally,this compound is condensed with phosgene.

参考文献标题:
文献作者:Fourneau; et al.
参考来源:Compt Rend Acad Sci 1924,178675


合成路线:Several procedures for obtaining titte compound have been reported:In one method the acylation of 1 naphthylamine 4,6,8-trisulfonic acid trisodium salt (I) with 4 methyl-3-nitrobenzoyt chloride (II) yields the correspond ing amide (III),which is reduced with Fe in acetic acid to the amine (IV).Acylation of (IV) with 3-nitrobenzoyl chloride (V) affords the nitro diamide (VI),which is reduced with Fe and acetic acid before to the amine (VII).Finally,this compound is condensed with phosgene.

参考文献标题:The manufacture of a symmetrical urea of m-aminobenzoyl-m-aminomethylbenzoyl-1-napthylamino-4,6,8-trisulphonate of sodium
文献作者:Freres,P.; Foruneau,E.; Trefouel,J.
参考来源:GB 224849


合成路线:Several procedures for obtaining titte compound have been reported:In one method the acylation of 1 naphthylamine 4,6,8-trisulfonic acid trisodium salt (I) with 4 methyl-3-nitrobenzoyt chloride (II) yields the correspond ing amide (III),which is reduced with Fe in acetic acid to the amine (IV).Acylation of (IV) with 3-nitrobenzoyl chloride (V) affords the nitro diamide (VI),which is reduced with Fe and acetic acid before to the amine (VII).Finally,this compound is condensed with phosgene.
参考文献标题:
文献作者:Heymann
参考来源:Angew Chem 1924,37585


产品链接: CAS No. 129-46-4››

产品链接: CAS No.145-63-1››