项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Idraparinux sodium, S-O-34006, Org-34006, SanOrg-34006, SR-34006

艾屈肝素钠Chemical Name: Methyl O-2,3,4-tri-O-methyl-6-O-sulfo-alpha-D-glucopyranosyl-(1--4)-O-2,3-di-O-methyl-beta-D-glucopyranuronosyl-(1--4)-O-2,3,6-tri-O-sulfo-alpha-D-glucopyranosyl-(1--4)-O-2,3-di-O-...
参考文献标题:Carbohydrate derivs.comprising a trisaccharide unit
文献作者:van Boeckel,C.A.A.; Petitou,M.(Akzo Nobel N.V.; Sanofi-Synthabo)
参考来源:EP 0454220; JP 1992225994; US 5378829; US 5382570; US 5529985; US 5773605

Iguratimod, T-614, Kolbet, Careram

艾拉莫德Chemical Name: 3-(Formylamino)-7-(methylsulfonamido)-6-phenoxy-4H-1-benzopyran-4-one
CAS No. 123663-49-0
项目整合开发状态: Pre-Registered
项目研究机构: Toyama (Originator), Dong-A (Licensee), Eisai (Li...
参考文献标题:4H-Benzopyran-4-one derivs.and their salts,their processes of production and pharmaceutical compsns.containing them
文献作者:Takano,S.; Yoshida,C.; Inaba,T.; Tanaka,K.; Takeno,R.; Nagaki,H.; Shimotori,T.; Makino,S.(Toyama Chemical Co.,Ltd.)
参考来源:AU 8823489; CH 679397; FR 2621585; GB 2210879; JP 1995267943; US 4954518

E-7389, B-1939, NSC-707389, ER-086526

艾日布林Chemical Name: (1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,35R,36S)-20-[3-Amino-2(S)-hydroxypropyl]-21-methoxy-14-methyl-8,15-dimethylene-2,19,30,34,37,39,40,41-octaoxanonacyclo[24.9....
参考文献标题:Macrocyclic analogs and methods of their use and preparation
文献作者:Littlefield,B.A.; Zheng,W.; Seletsky,B.M.; Yu,M.J.; Palme,M.H.; Towle,M.J.(Eisai Co.,Ltd.)
参考来源:US 6214865; WO 9965894

Ilaprazole, IY-81149

艾普拉唑Chemical Name: 2-(4-Methoxy-3-methylpyridin-2-ylmethylsulfinyl)-5-(1-pyrrolyl)-1H-benzimidazole
CAS No. 172152-36-2
项目整合开发状态: Phase II
项目研究机构: Il-Yang (Originator), Axcan (Licensee)
合成...
参考文献标题:Novel 5-pyrrolyl-2-pyridylmethylsulfinyl benzimidazole derivs.
文献作者:Kim,S.U.; Kim,D.Y.; Chung,G.J.; Hong,S.K.; Park,S.J.; Nam,S.H.; Lee,Y.S.(Il-Yang Pharmaceutical Co.,Ltd.)
参考来源:EP 0696281; JP 1997503000; US 5703097; WO 9523140

Etifoxin, Etifoxine, 36-801, Hoe-36-801

艾替伏辛Chemical Name: 6-Chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine
CAS No. 21715-46-8
项目整合开发状态: Biological Testing
项目研究机构:
合成路线:This compound can be obtained by two related w...
参考文献标题:2-Ethylamino-6-chloro-4-methyl-4-phenyl-4H-3,1,benzoxazine,a new psychotropic compound
文献作者:Hoffman,I.; et al.
参考来源:Arzneim-Forsch Drug Res 1970,20(7),975

KP-103

艾氟康唑Chemical Name: (R,R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(1,2,4-triazol-1-yl)-2-butanol
CAS No. 164650-44-6
项目整合开发状态: Phase I
项目研究机构: Kaken (Originator)
合成路线:Condens...
参考文献标题:Synthesis and antifungal activities of (2R,3R)-2-aryl-1-azolyl-3-(substituted amino)-2-butanol derivatives as topical antifungal agents
文献作者:Ogura,H.; Kobayashi,H.; Nagai,K.; Nishida,T.; Naito,T.; Tatsumi,Y.; Yokoo,M.; Arika,T.
参考来源:Chem Pharm Bull 1999,47(10),1417

B-1794, NSC-707390, ER-076349

艾瑞布林中间体Chemical Name: (1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,35R,36S)-20-[2(S),3-Dihydroxypropyl]-21-methoxy-14-methyl-8,15-dimethylene-2,19,30,34,37,39,40,41-octaoxanonacyclo[24.9.2...
参考文献标题:Macrocyclic analogs and methods of their use and preparation
文献作者:Littlefield,B.A.; Zheng,W.; Seletsky,B.M.; Yu,M.J.; Palme,M.H.; Towle,M.J.(Eisai Co.,Ltd.)
参考来源:US 6214865; WO 9965894

Rupatadine fumarate, UR-12592 fumarate, Alergoliber, Rupafin

芦帕他定 8-氯-6,11-二氢-11-[1-[(5-甲基-3-吡啶基)甲基]-4-亚哌啶基]-5H-苯并[5,6]环戊烷[1,2-b]吡啶盐酸盐 Chemical Name: 8-Chloro-11-[1-[(5-methyl-3-pyridyl)methyl]piperidin-4-ylidene]-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyri...
参考文献标题:Rupatadine Fumarate
文献作者:Garc韆-Rafanell,J.
参考来源:Drugs Fut 1996,21(10),1032

Fenprostalene, RS-84043, Synchrocept B(Veterinary)

芬前列林Chemical Name: 7-[(1R*,2R*,3R*,5S*)-3,5-Dihydroxy-2-[(1E,3R*)-3-hydroxy-4-phenoxy-1-butenyl]cyclopentyl}-4,5-heptadienoic acid methyl ester
CAS No. 69381-94-8
项目整合开发状态: Biological Testing 参考文献标题:Fenprostalene
文献作者:Serradell,M.N.; Castar,J.; Adaikan,P.G.; Kottegoda,S.R.
参考来源:Drugs Fut 1984,9(11),817

Alnovin, Fendosal, P 71-0129, HP-129

芬度柳Chemical Name: 5-(4,5-Dihydro-2-phenyl-3H-benz[e]indol-3-yl)salicylic acid; 3-(3-Carboxy-4-hydroxy-phenyl)-2-phenyl-4,5-dihydro-3H-benz[e]indole
CAS No. 53597-27-6
项目整合开发状态: Biological Testin...
参考文献标题:Fendosal
文献作者:Castar,J.; Arrigoni-Martelli,E.
参考来源:Drugs Fut 1976,1(7),320