Alnovin, Fendosal, P 71-0129, HP-129
芬度柳Chemical Name: 5-(4,5-Dihydro-2-phenyl-3H-benz[e]indol-3-yl)salicylic acid; 3-(3-Carboxy-4-hydroxy-phenyl)-2-phenyl-4,5-dihydro-3H-benz[e]indole
CAS No. 53597-27-6
项目整合开发状态: Biological Testing
项目研究机构: Aventis Pharma (Originator)
合成路线:The reaction of beta-tetralone (I) with pyrrolidine (A) yields enamine (II),which is condensed with phenacyl bromide (B) in DMF to give the 1-phenacyl-2-tetralone (III).Finally,this diketone is cyclized with 5-aminosalycilic acid (C) in refluxing acetic acid.
📌 参考资料/链接：
参考文献标题:Fendosal
文献作者:Castar,J.; Arrigoni-Martelli,E.
参考来源:Drugs Fut 1976,1(7),320
📄 详细内容
合成路线:The reaction of beta-tetralone (I) with pyrrolidine (A) yields enamine (II),which is condensed with phenacyl bromide (B) in DMF to give the 1-phenacyl-2-tetralone (III).Finally,this diketone is cyclized with 5-aminosalycilic acid (C) in refluxing acetic acid.
参考文献标题:Carboxyarylindoles as non steroidal anti-inflammatory agents
文献作者:Anderson,V.B.; Agnew,M.N.; Allen,R.C.; Wilker,J.C.; Lassman,H.B.; Novick,W.J.Jr.
参考来源:J Med Chem 1976,1(7),320
产品链接: CAS No. 53597-27-6››