ORG-25969
舒更葡糖钠 舒更葡糖钠 Chemical Name: 6A,6B,6C,6D,6E,6F,6G,6H-Octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G-octasulfanyl-gamma-cyclodextrin octasodium salt
CAS No. 343306-79-6, 343306-71-8 (free acid)
项目整合开发状态: Phase II
项目研究机构: Akzo Nobel (Originator), Organon (Not Determined)
合成路线:Gamma-cyclodextrin (I) was converted to the halogen derivative (II) by treatment with iodine or bromine and triphenylphosphine.Nucleophilic displacement of the halogen atoms of (II) with the sodium salt of 3-mercaptopropionic acid furnished the title compound
📌 参考资料/链接：
参考文献标题:6-Mercapto-cyclodextrin derivs.: Reversal agents for drug-induced neuromuscular block
文献作者:Bennet,D.J.; Palin,R.; Zhang,M.(Akzo Nobel N.V.)
参考来源:WO 0140316
📄 详细内容
合成路线:Gamma-cyclodextrin (I) was converted to the halogen derivative (II) by treatment with iodine or bromine and triphenylphosphine.Nucleophilic displacement of the halogen atoms of (II) with the sodium salt of 3-mercaptopropionic acid furnished the title compound
参考文献标题:Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: Synthesis and structure-activity relationships
文献作者:Adam,J.M.; Bennet,D.J.; Bom,A.; Clark,J.K.; Feilden,H.; Hutchinson,E.J.; Palin,R.; Prosser,A.; Rees,D.C.; Rosair,G.M.; Stevenson,D.; Tarver,G.J.; Zhang,M.Q.
参考来源:J Med Chem 2002,45(9),1806
产品链接: CAS No. 343306-79-6›› 产品链接: CAS No.343306-71-8››