项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Brovavir, Sorivudine, BV-araU, SQ-32756, YN-72, BVAU, Bravavir, Usevir

索立夫定Chemical Name: (+)-1-beta-D-Arabinofuranosyl-5-[(E)-2-bromovinyl]uracil; (+)-(E)-1-beta-D-Arabinofuranosyl-5-(2-bromoethenyl)-2,4(1H,3H)-pyrimidinedione
CAS No. 77181-69-2
项目整合开发状态: Withdraw...
参考文献标题:BVAU
文献作者:Sakata,S.; Machida,H.
参考来源:Drugs Fut 1982,7(7),458

Intaxel(from Himalayan Yew), Paclitaxel, BMS-181339, NSC-125973, MPI-5018(with Matrix's anhydrous delivery system), Genaxol, Pacligel, Paxceed, Genexol, Paxoral(oral formulation), Nanotaxel, Xorane, Taxol, Paxene, Yewtaxan, Anzatax

紫杉醇Chemical Name: [2aR-[2aalpha,4beta,4abeta,6beta,9alpha(2R,3S),11beta,12alpha,12aalpha,12balpha]]-6,12b-Diacetoxy-9-(3-benzamido-2-hydroxy-3-phenylpropionyloxy)-12-(benzoyloxy)-4,11-dihydroxy-4a,8,1...
参考文献标题:Process for the preparation of taxol and 10-deacetyltaxol
文献作者:Colin,M.; Guenard,D.; Gueritte-Voegelein,F.; Potier,P.(Aventis SA)
参考来源:US 4857653

Nalmetrene(former INN, USAN), Nalmefene, NIH-10365(HCl), ORF-11676, JF-1, Cessal, Soberal, Alcofene, Revex(HCl), Arthene, Cervene, Incystene

纳美芬Chemical Name: N-(Cyclopropylmethyl)-4,5alpha-epoxy-6-methylenemorphinan-3,14beta-diol
CAS No. 55096-26-9
项目整合开发状态: Launched-1995
项目研究机构: Baker Norton (Originator), BioTie Therapies (Not D...
参考文献标题:17-Substituted-6-desoxy-7,8-dihydro-6alpha-methylnoroxymorphone narcotic antagonists
文献作者:Hermann,E.C.; Lee,K.T.; Myers,M.J.(DuPont Pharmaceuticals Co.)
参考来源:EP 0039066; JP 167687; US 4322426

Vesnarinone, OPC-8212, Arkin, Arkin-Z

维司力农Chemical Name: 1-(1,2,3,4-Tetrahydro-2-oxo-6-quinolyl)-4-veratroylpiperazine; 6-[4-(3,4-Dimethoxybenzoyl)-1-piperazinyl]-1,2,3,4-tetrahydro-2-quinolinone
CAS No. 81840-15-5
项目整合开发状态: Launche...
参考文献标题:OPC-8212
文献作者:Mannhold,R.
参考来源:Drugs Fut 1985,10(1),28

Vecuronium bromide, Org-NC-45, Norcuron

维库溴铵Chemical Name: 1-[(2beta,3alpha,5alpha,16beta,17beta)-3,17-Diacetoxy-2-(1-piperidinyl)androstan-16-yl]-1-methylpiperidinium bromide; 3alpha,17beta-Diacetoxy-2beta,16beta-bis(1-piperidino)androstan...
参考文献标题:ORG-NC-45
文献作者:Serradell,M.N.; Castar,J.; Blancafort,P.; Hillier,K.
参考来源:Drugs Fut 1981,6(5),287

Verapamil, Calan, Securon, Cordilox, Verelan PM, Chronovera, Covera-HS(controlled onset, extended release system), Isoptin(HCl)

维拉帕米盐酸维拉帕米 Chemical Name: 5-[N-[2-(3,4-Dimethoxyphenyl)ethyl]-N-methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile
CAS No. 52-53-9, 152-11-4 (HCl)
项目整合开发状态: Launched-1963
项目研究机构: ...
参考文献标题:Basically substd.phenyl acetonitrile cpds.
文献作者:Dengel,F.(Knoll AG)
参考来源:US 3261859

Veralipride, LIR-1660, Agreal

维拉必利维拉必利 Chemical Name: N-[(1-Allyl-2-pyrrolidinyl)methyl]-5-sulfamoyl-o-veratramide; 5-(Aminosulfonyl)-2,3-dimethoxy-N-[[1-(2-propenyl)-2-pyrrolidinyl]methyl]benzamide
CAS No. 66644-81-3, 66644-8...
参考文献标题:Veralipride
文献作者:Castar,J.; Serradell,M.N.; Neuman,M.; Blancafort,P.
参考来源:Drugs Fut 1981,6(1),46

Vitamin K2(20), Menaquinone-4, Menatetrenone, E-0167, MQ-4, MK-4, Ea-0167, Kaytwo(vitamin K deficiency), Glakay(osteoporosis)

维生素 K2 甲氧基肾上腺素维生素K2杂质01Chemical Name: (all E)-2-Methyl-3-(3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl)-1,4-naphthoquinone
CAS No. 863-61-6, 6041-00-5 (undefined isomer), 65061-19-0 (Z,E,E-is...
参考文献标题:Manufacturing method for trans-vitamin K2
文献作者:Ichino,T.; Nakano,K.; Murakami,K.; Narabe,Y.; Imai,A.; Takahashi,K.; Udagawa,T.; Kusaba,Y.; Muramatsu,T.; Katayama,A.(Eisai Co.,Ltd.)
参考来源:JP 1988162649

Sch-417690, SCH-D

维立韦罗 Vicriviroc马来酸盐 Chemical Name: 1-(4,6-Dimethylpyrimidin-5-yl)-1-[4-[4-[2-methoxy-1(R)-[4-(trifluoromethyl)phenyl]ethyl]-3(S)-methylpiperazin-1-yl]-4-methylpiperidin-1-yl]methanone; 5-[4-[4-[2-meth...
参考文献标题:Cyclic amide cpds.,process for the preparation of the same and uses thereof
文献作者:Imamura,S.; Baba,M.; Ishihara,Y.; Hashiguchi,S.; Kanzaki,N.; Nishimura,O.(Takeda Chemical Industries,Ltd.)
参考来源:EP 1180513; JP 2001011073; WO 0066551

Vildagliptin, LAF-237, NVP-LAF-237

维达列汀Chemical Name: 1-[2-(3-Hydroxyadamant-1-ylamino)acetyl]pyrrolidine-2(S)-carbonitrile
CAS No. 274901-16-5, 565453-38-5 (deleted CAS)
项目整合开发状态: Phase III
项目研究机构: Novartis (Originator)
合成...
参考文献标题:N-Substd.2-cyanopyrrolidines
文献作者:Villhauer,E.B.(Novartis AG)
参考来源:EP 1137635; JP 2002531547; US 6166063; WO 0034241