Verapamil, Calan, Securon, Cordilox, Verelan PM, Chronovera, Covera-HS(controlled onset, extended release system), Isoptin(HCl)

维拉帕米 盐酸维拉帕米 Chemical Name: 5-[N-[2-(3,4-Dimethoxyphenyl)ethyl]-N-methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile
CAS No. 52-53-9, 152-11-4 (HCl)
项目整合开发状态: Launched-1963
项目研究机构: Abbott (Originator), Pfizer (Licensee)
合成路线:The condensation of 2-(3,4-dimethoxyphenyl)-3-methylbutyronitrile (I) with N-(3-chloropropyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylamine (II) by means of sodium amide in refluxing toluene gives the target aminonitrile.