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项目整合精选>>>Nalmetrene(former INN, USAN), Nalmefene, NIH-10365(HCl), ORF-11676, JF-1, Cessal, Soberal, Alcofene, Revex(HCl), Arthene, Cervene, Incystene
Nalmetrene(former INN, USAN), Nalmefene, NIH-10365(HCl), ORF-11676, JF-1, Cessal, Soberal, Alcofene, Revex(HCl), Arthene, Cervene, Incystene
纳美芬Chemical Name: N-(Cyclopropylmethyl)-4,5alpha-epoxy-6-methylenemorphinan-3,14beta-diol
CAS No. 55096-26-9
项目整合开发状态: Launched-1995
项目研究机构: Baker Norton (Originator), BioTie Therapies (Not Determined), Baxter (Licensee), SSP (Licensee)
合成路线:By a Wittig reaction at naltrexone (I) with triphenylmethylphosphonium bromide (II) in DMSO by means of NaH as base.
📌 参考资料/链接：
参考文献标题:17-Substituted-6-desoxy-7,8-dihydro-6alpha-methylnoroxymorphone narcotic antagonists
文献作者:Hermann,E.C.; Lee,K.T.; Myers,M.J.(DuPont Pharmaceuticals Co.)
参考来源:EP 0039066; JP 167687; US 4322426
📄 详细内容
合成路线:By a Wittig reaction at naltrexone (I) with triphenylmethylphosphonium bromide (II) in DMSO by means of NaH as base.
参考文献标题:Nalmefene
文献作者:Serradell,M.N.; Castar,J.
参考来源:Drugs Fut 1984,9(7),518
合成路线:By a Wittig reaction at naltrexone (I) with triphenylmethylphosphonium bromide (II) in DMSO by means of NaH as base.
参考文献标题:Narcotic antagonists.4.Carbon-6 derivatives of N-substituted noroxymorphones as narcotic antagonists
文献作者:Heilman,R.D.; Hahn,E.F.; Fishman,J.
参考来源:J Med Chem 1975,18(3),259-262
产品链接: CAS No. 55096-26-9››