项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

项目整合精选

Valganciclovir hydrochloride, TA-9070, Ro-10-79070/194, RS-79070-194, RS-79070(free base), Valcyte, Valcyt, Cymeval

缬更昔洛韦盐酸盐Chemical Name: 5-Amino-3-[1-(hydroxymethyl)-2-(L-valyloxy)ethoxymethyl]-6,7-dihydro-3H-imidazo[4,5-d]pyrimidin-7-one hydrochloride; L-Valine 2-(guanin-9-ylmethoxy)-3-hydroxypropyl ester hydroc...
参考文献标题:2-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol deriv.
文献作者:Nestor,J.J.; Womble,S.W.; Maag,H.(F.Hoffmann-La Roche AG)
参考来源:CA 2154721; EP 0694547; ES 2083348; JP 1996041061; US 5840891; US 6083953

Valsartan, VAL-489, CGP-48933, Nisis, Kalpress, Vals, Miten, Varexan, Provas, Valpression, Tareg, Diovan

缬沙坦Chemical Name: N-Pentanoyl-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-L-valine
CAS No. 137862-53-4
项目整合开发状态: Launched-1996
项目研究机构: Novartis (Originator), Esteve (Licensee), Ipsen (Licens...
参考文献标题:Acyl cpds.
文献作者:B黨lmayer,P.; Ostermayer,F.; Schmidlin,T.(Novartis AG)
参考来源:EP 0443983; JP 1992235149; US 5399578; US 5965592

Rokitamycin, TMS-19-Q DS 200, TMS-19Q, Rokicid, Rokital, Ricamycin

罗他霉素Chemical Name: 3''-O-Propionylleucomycin A5
CAS No. 74014-51-0
项目整合开发状态: Launched-1986
项目研究机构: Pierre Fabre (Originator), Toyo Jozo (Originator), Formenti (Licensee), ISF (Licensee)
合成...
参考文献标题:TMS-19Q
文献作者:Serradell,M.N.; Castar,J.; Burnie,J,Matthews,R.
参考来源:Drugs Fut 1985,10(6),486

Roxindole mesilate, EMD-62100(free base), EMD-38362(HCl), EMD-49980

罗克吲哚甲磺酸盐罗新朵 3-[4-(3,6-二氢-4-苯基-1(2H)-吡啶基)丁基]-1H-吲哚-5-醇盐酸盐Chemical Name: 5-Hydroxy-3-[4-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)butyl]-1H-indole methanesulfonate
CAS No. 119742-13-1, 112192-04-8 (f...
参考文献标题:Use of hydroxyindole derivs.for the preparation of an antihypertensive agent
文献作者:Hausberg,H.-H.; B鰐tcher,H.; Seyfried,C.; Bergmann,R.(Merck Patent GmbH)
参考来源:DE 3419935; EP 0166183; JP 1985258117; US 4711893

Ropivacaine, LEA-103(HCl), AL-281

罗哌卡因Chemical Name: (-)-1-Propyl-2',6'-pipecoloxylidide
CAS No. 84057-95-4
项目整合开发状态: Launched
项目研究机构: AstraZeneca (Originator), Pierrel (Licensee)
合成路线:Optical resolution of DL-pipecolinic ...
参考文献标题:L-N-n-Propylpipecolic acid-2,6-xylidide and method for preparing the same
文献作者:T.af Ekenstam,B.; Bovin,C.(Alpharma Inc.)
参考来源:JP 1985502054; WO 8500599

Ropivacaine hydrochloride, AL-281(anhydrous free base), LEA-103, Naropina, Anapaine, Naropin

罗哌卡因Chemical Name: (-)-(S)-N-(n-Propyl)piperidine-2-carboxylic acid 2,6-xylidide hydrochloride monohydrate; (-)-(S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride monohydrate; (...
参考文献标题:L-N-n-Propylpipecolic acid 2,6-xylidide
文献作者:T.af Ekenstam,B.; Bovin,C.(Astra L鋕emedel AB)
参考来源:US 4695576

Rocuronium bromide, Org-9426, Esmeron, Zemuron

罗库溴铵Chemical Name: 1-[(2beta,3alpha,5alpha,16beta,17beta)-17-(Acetyloxy)-3-hydroxy-2-(4-morpholinyl)androstan-16-yl]-1-(2-propenyl)pyrrolidinium bromide; 1-Allyl-1-(3alpha,17beta-dihydroxy-2beta-morph...
参考文献标题:Novel 2beta-morpholino-androstane derivs.and process for their preparation
文献作者:Savage,D.S.; Sleig,T.; Carlyle,I.G.(Akzo Nobel N.V.)
参考来源:AU 8814570; EP 0287150; JP 1988277693; US 4894369

Rolziracetam, CI-911

罗拉西坦Chemical Name: Dihydro-1H-pyrrolizine-3,5(2H,6H)-dione
CAS No. 18356-28-0
项目整合开发状态: Biological Testing
项目研究机构: Pfizer (Originator)
合成路线:The reductive cyclization of dimethyl 4-nitropim...
参考文献标题:Use of dihydro-1H-pyrrolizine-3,5(2H,6H)-dione as a cognition activator
文献作者:Butler,D.E.(Pfizer Inc.)
参考来源:DD 201797; EP 0048132; US 4372966

Roxifiban acetate, SC-887(mesylate), DMP-755(free base), XU-070(HCl), DMP-754, Lumaxis

罗昔非班乙酸盐 L-丙氨酸,3-[[2-[(5R)-3-[4-(氨基亚氨基甲基)苯基]-4,5-二氢-5-is氧唑基乙酰氨基]-N-(丁氧羰基)-甲基酯 Chemical Name: 3-[2-[3-(4-Amidinophenyl)-4,5-dihydroisoxazol-5(R)-yl]acetamido]-2(S)-(butoxycarboxamido)propionic acid meth...
参考文献标题:An efficient method for the conversion of nitriles to amidines
文献作者:Confalone,P.N.; Li,H.-Y.; Ma,P.(DuPont Pharmaceuticals Co.)
参考来源:WO 9918090

N-0437

罗替戈汀Chemical Name: 2-[N-Propyl-N-[2-(2-thienyl)ethyl]amino]-5-hydroxytetralin hydrochloride
CAS No. 92206-54-7 (free base)
项目整合开发状态: Phase I
项目研究机构: UCB (Originator)
合成路线:The methylation o...
参考文献标题:N-0437
文献作者:Horn,A.S.
参考来源:Drugs Fut 1987,12(3),220