Rolziracetam, CI-911
罗拉西坦Chemical Name: Dihydro-1H-pyrrolizine-3,5(2H,6H)-dione
CAS No. 18356-28-0
项目整合开发状态: Biological Testing
项目研究机构: Pfizer (Originator)
合成路线:The reductive cyclization of dimethyl 4-nitropimelate (I) with H2 over Pd/C in methanol gives 3-(2-oxo-5-pyrrolidinyl)propanoic acid (II),which is then treated with hot acetic anhydride.
📌 参考资料/链接：
参考文献标题:Use of dihydro-1H-pyrrolizine-3,5(2H,6H)-dione as a cognition activator
文献作者:Butler,D.E.(Pfizer Inc.)
参考来源:DD 201797; EP 0048132; US 4372966
📄 详细内容
合成路线:The reductive cyclization of dimethyl 4-nitropimelate (I) with H2 over Pd/C in methanol gives 3-(2-oxo-5-pyrrolidinyl)propanoic acid (II),which is then treated with hot acetic anhydride.
合成路线:Dexanabinol (I) was brominated using carbon tetrabromide in the presence of triphenylphosphine.The resultant allylic bromide (II) was then condensed with the lithium salt of imidazole (III) to produce the title compound.
参考文献标题:Novel non-psychotropic cannabinoids
文献作者:Fink,G.; Garzon,A.(Pharmos Corp.)
参考来源:WO 0198289
产品链接: CAS No. 18356-28-0››