项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Gemeprost, SC-37681, Ono-802, Cergem, Preglandin, Cervagem

吉美前列素Chemical Name: (E)-7-[(1R,2R,3R-3-Hydroxy-2-[(E)-(3R)-3-hydroxy-4,4-dimethyl-1-octenyl]-5-oxocyclopentyl]-2-heptenoic acid methyl ester; 16,16-Dimethyl-DELTA2-trans-PGE1 methyl ester; 9-Oxo-11alp...
参考文献标题:ONO-802
文献作者:Castar,J.; Leeson,P.
参考来源:Drugs Fut 1979,4(1),38

Gemcitabine, dFdC, LY-188011, Gemzar(HCl)

吉西他滨盐酸吉西他滨 Chemical Name: 1-(4-Amino-2-oxo-1H-pyrimidin-1-yl)-2-deoxy-2,2-difluoro-beta-D-ribofuranose; 2'-Deoxy-2',2'-difluorocytidine
CAS No. 95058-81-4, 122111-03-9 (monoHCl)
项目整合开发状态: Launc...
参考文献标题:The synthesis of the H-2,H-3,and C-14-isotopomers of 2'-deoxy-2',2'-difluorocytidine hydrochloride,an anti-tumor compoundv
文献作者:Jones,C.D.; Wheeler,W.J.; Mabry,T.E.
参考来源:J Label Compd Radiopharm 1991,29(5),583

Gefitinib, ZD-1839, Iressa

吉非替尼 4-(3-氯-4-氟苯基氨基)-7-甲氧基-6-[3-(4-吗啉基)丙氧基]喹唑啉二盐酸盐 Chemical Name: 4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline
CAS No. 184475-35-2, 184475-56-7 (diHCl), 18447...
参考文献标题:Quinazoline derivs.
文献作者:Gibson,K.H.(AstraZeneca plc)
参考来源:EP 0823900; JP 1999504033; US 5770599; WO 9633980

Gemfibrozil, GEM, CI-719, Gevilon, Lipur, Lipozid, Innogem, Lopid

吉非罗齐Chemical Name: 2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid; 2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid
CAS No. 25812-30-0
项目整合开发状态: Launched-1982
项目研究机构: Pfizer (Originator), Egis (...
参考文献标题:Gemfibrozil
文献作者:Sungurbey,K.; Castar,J.
参考来源:Drugs Fut 1976,1(11),520

Gimatecan, LBQ-707, CPT-184, ST-1481

吉马替康Chemical Name: 7-(tert-Butoxyiminomethyl)camptothecin; (4S)-4-Ethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-11-carbaldehyde O-(tert-butyl)oxime
...
参考文献标题:Camptothecin derivs.having antitumor activity
文献作者:Carminati,P.; Penco,S.; Zunino,F.; Merlini,L.(Istituto Nazionale per lo Studio e la Cura dei Tumori; Sigma-Tau Industrie Farmaceutiche Riunite SpA)
参考来源:EP 1044977; WO 0053607

Morniflumate, UP-164, Niflam, Morniflu

吗尼氟酯Chemical Name: 2-[3-(Trifluoromethyl)phenylamino]pyridine-3-carboxylic acid 2-morpholinoethyl ester; 2-Morpholinoethyl ester of niflumate
CAS No. 65847-85-0
项目整合开发状态: Launched-1981
项目研究机构...
参考文献标题:Processes for the preparation of morniflumate and analogous cpds.
文献作者:Chiesi,P.; Servadio,V.; Pighi,R.(Chiesi Farmaceutici SpA)
参考来源:EP 0349902

Mycophenolate mofetil, RS-61443-190(HCl), ME-MPA, RS-61443, Munoloc, CellCept

吗替麦考酚酯吗替麦考吩酯 Chemical Name: 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)-4-methyl-4(E)-hexenoic acid 2-(4-morpholinyl)ethyl ester; Mycophenolic acid 2-(4-morpholinyl)ethyl est...
参考文献标题:Morpholinoethylesters of mycophenolic acid and pharmaceutical compsns
文献作者:Nelson,P.H.; Gu,C.-L.L.; Allison,A.C.; Eugui,E.M.; Lee,W.A.(Syntex (USA),Inc.)
参考来源:AU 8782540; EP 0281713; JP 1988188672; US 4753935

Moclobemide, Ro-11-1163, Moclamine, Manerix, Aurorix

吗氯贝胺Chemical Name: 4-Chloro-N-[2-(4-morpholinyl)ethyl]benzamide
CAS No. 71320-77-9
项目整合开发状态: Launched-1990
项目研究机构: Roche (Originator), Dainippon Pharmaceutical (Licensee)
合成路线:This compoun...
参考文献标题:Benzamides
文献作者:Bukard,W.; Wyss,P.C.(F.Hoffmann-La Roche AG)
参考来源:BE 0851422; CA 1076112; DE 2706179; FR 2340940; GB 1512194; JP 52100476; NL 7701144; US 4210754; ZA 7700488

Pirlimycin hydrochloride, U-57930E

吡利霉素Chemical Name: Methyl 7-chloro-6,7,8-trideoxy-6-[[(cis-4-ethyl-2-piperidinyl)carbonyl]amino]-1-thio-L-threo-alpha-D-galacto-octopyranoside hydrochloride hydrate; cis-4-Ethyl-L-pipecolic acid amide...
参考文献标题:Novel antibiotics,their preparation and their use
文献作者:Birkenmeyer,R.D.(Pharmacia Corp.)
参考来源:BE 0886301

Piriprost, U-60257

吡前列素吡前列素钾盐 Chemical Name: 6,9-Deepoxy-6,9-(phenylimino)-DELTA6,8-prostaglandin I1; [4R-[4alpha(1E,3S*),5beta]]-1,4,5,6-Tetrahydro-5-hydroxy-4-(3-hydroxy-1-octenyl)-1-phenylcyclopenta[b]pyrrole-2-pent...
参考文献标题:Nitrogen-containing prostacyclin analogues,their preparation and compsns.containing them
文献作者:Smith,H.W.(Pharmacia Corp.)
参考来源:EP 0029341