Morniflumate, UP-164, Niflam, Morniflu

吗尼氟酯Chemical Name: 2-[3-(Trifluoromethyl)phenylamino]pyridine-3-carboxylic acid 2-morpholinoethyl ester; 2-Morpholinoethyl ester of niflumate
CAS No. 65847-85-0
项目整合开发状态: Launched-1981
项目研究机构: Chiesi (Originator)
合成路线:In a different procedure,2-chloronicotinic acid (III) was chlorinated to (IV) by means of boiling thionyl chloride.Condensation of acid chloride (IV) with 2-morpholinoethanol (V) gave rise to the morpholinoethyl chloronicotinate (VI).Finally,displacement of the 2-chloro with m-(trifluoromethyl)aniline (VII) in the presence of zinc oxide and iodine furnished the title compound.

合成路线:Alternatively,acid chloride (IV),prepared from 2-chloronicotinic acid (III),was treated with methanol and triethylamine to afford the methyl ester (VIII).Displacement of the 2-chloro with m-(trifluoromethyl)aniline (VII) yielded methyl niflumate (IX).Finally,transesterification of methyl ester (IX) with 2-morpholinoethanol (V) in the presence of sodium metal gave rise to the title compound.