项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

Dexrazoxane, ADR-529, NSC-169780, ICRF-187(HCl)

右雷佐生Chemical Name: (+)-(S)-4,4'-(Propane-1,2-diyl)bis(piperazine-2,6-dione)
CAS No. 24584-09-6
项目整合开发状态: Not Determined
项目研究机构: Cancer Research UK (Originator)
合成路线:(rac)-1,2-Diaminopropan...
参考文献标题:ICRF-187
文献作者:Eastland,G.
参考来源:Drugs Fut 1987,12(11),1017

Dexrazoxane hydrochloride, ADR-529(free base), NSC-169780(free base), ICRF-187, TopoTect, Zinecard, Cardioxane

右雷佐生Chemical Name: (+)-(S)-4,4'-(Propane-1,2-diyl)bis(piperazine-2,6-dione) hydrochloride
CAS No. 24584-09-6 (free base)
项目整合开发状态: Launched-1992
项目研究机构: Pfizer (Orphan Drug), Cancer Research ...
参考文献标题:Process for preparing (S)(+)-4,4'-(1-methyl-1,2-ethanediyl)-bis(2,6-piperazinedione)
文献作者:Miller,W.D.
参考来源:EP 0284594

Sanilvudine, Stavudine, BMY-27857, d4T, DTH, ddeThd, Zerit

司他夫定Chemical Name: 3'-Deoxy-2'-thymidinene; 3'-Deoxy-2',3'-didehydrothymidine; 1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine
CAS No. 3056-17-5
项目整合开发状态: Launched-1994
项目研究机构: Bris...
参考文献标题:Processes for preparation of nucleoside derivs
文献作者:Kim,C.U.; Martin,J.C.(Bristol-Myers Squibb Co.)
参考来源:EP 0501511

Setazindol, PRF-36

司他秦多 4-氯-2'-[(甲基氨基)甲基]二苯甲醇盐酸盐 Chemical Name: 4-Chloro-2'-(methylaminomethyl)diphenylmethanol
CAS No. 56481-43-7, 27683-73-4 (HCl)
项目整合开发状态: Preclinical
项目研究机构: Boehringer Ingelheim (Originato...
参考文献标题:Setazindol
文献作者:Hillier,K.
参考来源:Drugs Fut 1979,4(5),365

Sparfloxacin, CP-103826, RP-64206, CI-978, PD-131501, AT-4140, Zagam, Spara

司帕沙星司帕沙星 Chemical Name: 5-Amino-1-cyclopropyl-7-(cis-3,5-dimethyl-1-piperazinyl)-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
CAS No. 110871-86-8, 111542-93-9 (undefined stereoch.) 参考文献标题:Novel quinoline derivatives and processes for preparation thereof
文献作者:Matsumoto,J.; Miyamoto,T.; Egawa,H.; Nakamura,S.(Dainippon Pharmaceutical Co.,Ltd.)
参考来源:AU 8664277; EP 0221463; JP 87277362

Esparsomicina, Sparsomycin(Rec INN, NFN, USAN), NSC 59729

司帕索霉素Chemical Name: [S-(E)]-N-[1-(Hydroxymethyl)-2-[[(methylthio)meth-yl]sulfinyl]ethyl]-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinyl)-2-propenamide
CAS No. 1404-64-4
项目整合开发状态: Biologi...
参考文献标题:Synthesis and morphological reversion activity on src(ts)NRK cells of pyrimidinylpropanamide antibiotics,sparsomycin,sparoxomycin A1,A2,and their analogues
文献作者:Nakajima,N.; Enomoto,T.; Matsuura,N.; Ubukata,M.
参考来源:Bioorg Med Chem Lett 1998,8(23),3331

Sematilide hydrochloride, RU-752, ZK-110516, CK-1752A

司美利特司美利特盐酸盐 Chemical Name: N-[2-(Diethylamino)ethyl]-4-[(methylsulfonyl)amino]benzamide monohydrochloride
CAS No. 101526-62-9, 101526-83-4 (free base)
项目整合开发状态: Phase III
项目研究机构: Berlex (Ori...
参考文献标题:Substituted sulfonamidobenzamides,antiarrhythmic agents and compositions thereof.
文献作者:Lumma,W.C.Jr.; Davey,D.D.; Wohl,R.A.(Berlex Laboratories,Inc.)
参考来源:EP 0158775; JP 85209559; US 4544654

Secoverine

司考维林Chemical Name: 1-Cyclohexyl-4-[ethyl(p-methoxy-alpha-methylphenethyl)amino]-1-butanone
CAS No. 57558-44-8, 57558-46-0 (HCl)
项目整合开发状态: Biological Testing
项目研究机构: Roche Bioscience (Originat...
参考文献标题:Secoverine hydrochloride
文献作者:Serradell,M.N.; Thorpe,P.J.; Blancafort,P.; Castar,J.
参考来源:Drugs Fut 1981,6(4),239

Semotiadil fumarate, Sesamodil fumarate, DS-4823, SD-3211

司莫地尔富马酸盐司莫地尔 Chemical Name: (+)-(R)-2-[5-Methoxy-2-[3-[N-methyl-N-[2-[3,4-(methylenedioxy)phenoxy]ethyl]amino]propoxy]phenyl]-4-methyl-3,4-dihydro-2H-1,4-benzothiazin-3-one hydrogen fumarate
CAS N...
参考文献标题:Novel benzothiazine derivs.
文献作者:Iwao,J.; Iso,T.; Oya,M.(Santen Pharmaceutical Co.,Ltd.)
参考来源:EP 0237573; JP 1987123181; US 4786635; WO 8700838

Sebriplatin, CI-973, NK-121

司铂Chemical Name: cis-(1,1-Cyclobutanedicarboxylato)-[(2R)-2-methyl-1,4-butanediamine]platinum II; cis-[1,1'-Cyclobutanedicarboxylato(2-)-O,O'](2(R)-methyl-1,4-butanediamine-N,N')platinum(II)
CAS No...
参考文献标题:NK-121
文献作者:Takahashi,K.; Kogawa,O.
参考来源:Drugs Fut 1989,14(1),31