Sematilide hydrochloride, RU-752, ZK-110516, CK-1752A
司美利特 司美利特盐酸盐 Chemical Name: N-[2-(Diethylamino)ethyl]-4-[(methylsulfonyl)amino]benzamide monohydrochloride
CAS No. 101526-62-9, 101526-83-4 (free base)
项目整合开发状态: Phase III
项目研究机构: Berlex (Originator), Schering AG (Originator), Roussel Morishita (Licensee)
合成路线:Reaction of p-aminobenzoic acid methyl ester (I) with methanesulfonyl chloride using pyridine as base provides the methanesulfonyl derivative (II).Heating (II) in heat N,N-diethyl-1,2-ethanediamine (III) at 140-50 C until complete disappearance of (II) gives the crude sematilide,which,after removal of excess diamine under vacuum,is crystallized as the hydrochloride salt from isopropanol/aqueous HCl.
📌 参考资料/链接：
参考文献标题:Substituted sulfonamidobenzamides,antiarrhythmic agents and compositions thereof.
文献作者:Lumma,W.C.Jr.; Davey,D.D.; Wohl,R.A.(Berlex Laboratories,Inc.)
参考来源:EP 0158775; JP 85209559; US 4544654
📄 详细内容
合成路线:Reaction of p-aminobenzoic acid methyl ester (I) with methanesulfonyl chloride using pyridine as base provides the methanesulfonyl derivative (II).Heating (II) in heat N,N-diethyl-1,2-ethanediamine (III) at 140-50 C until complete disappearance of (II) gives the crude sematilide,which,after removal of excess diamine under vacuum,is crystallized as the hydrochloride salt from isopropanol/aqueous HCl.
参考文献标题:SEMATILIDE HYDROCHLORIDE < Rec INNM; USAN >
文献作者:Lumma,W.C.Jr.
参考来源:Drugs Fut 1989,14(3),234
产品链接: CAS No. 101526-62-9›› 产品链接: CAS No.101526-83-4››