项目整合精选

聚焦新型临床类新产品的整合与转化. 在创新药研发领域，传统的“单一产品、单打独斗”模式正在被一种更系统化的“项目整合”思维所取代。项目整合的核心，在于将散落在研发早期、中期的创新资产，通过资金、临床资源、产业生态等多维度要素的有机组合，实现从“科学发现”到“临床价值”，再到“商业成功”的跨越。研发与商业的战略整合：从“资产思维”到“组合思维”它要求我们超越单个分子的视野，拥抱一个由技术创新、临床需求、资本支持和商业洞察共同构成的复杂网络。在这个网络中，成功的标准不再是单一的“获批上市”，而是能否通过高效的整合，将科学上的突破，转化为临床上真正可及、商业上可持续、能够惠及患者的解决方案。近年来，药物发现已从传统的小分子化药拓展至更多元的分子类型，这些新型API在项目整合中呈现出独特的开发范式，项目整合的核心挑战在于递送系统的设计与肝外靶向能力的突破。
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项目整合精选

SL-65.0472

丙酸,3-[[(1,1-二甲基乙氧基)羰基]氨基]-2-羟基-,甲基Chemical Name: 2-[7-Fluoro-2-oxo-4-[2-[4-(thieno[3,2-c]pyridin-4-yl)piperazin-1-yl]ethyl]-1,2-dihydroquinolin-1-yl]acetamide
CAS No. 189003-92-7, 189003-46-1 (diHC...
参考文献标题:Quinolein-2(1H)-one derivs.as serotonin antagonists
文献作者:Mc Cort,G.; Hoornaert,C.; Dellac,G.; Aletru,M.(Sanofi-Synthabo )
参考来源:EP 0850235; FR 2738822; FR 2739100; JP 1999514982; US 5958924; WO 9710238

Deprodone propionate, Eclar

丙酸地泼罗酮Chemical Name: (+)-11beta,17-Dihydroxy-1,4-pregnadiene-3,20-dione-17-propionate; (+)-11beta-Hydroxy-17-(propionyloxy)pregna-1,4-diene-3,20-dione; (+)-21-Desoxyprednisolone 17alpha-propionate
...
参考文献标题:Improvements in acylated steroids
文献作者:Housley,J.R.; Oxley,P.(The Boots Company plc)
参考来源:FR 1513708; GB 1158492

Dantrolene sodium, F-440, Dantrium

丹曲林钠 1-(((5-(4-硝基苯基)呋喃-2-基)亚甲基)氨基)咪唑烷-2,4-二酮 Chemical Name: 1-[5-(4-Nitrophenyl)furfurylideneamino]hydantoin sodium salt
CAS No. 14663-23-1, 7261-97-4 (free acid)
项目整合开发状态: Launched-1971
项目研究...
参考文献标题:Process for obtaining 1-[(5-(p-nitrophenyl)furfuryliden)amino]hydantoin and its sodium salt
文献作者:Martin-Escudero Perez,U.; Izquierdo Sanjose,M.
参考来源:ES 458000

Ubenimex, Ubestatin, NK-421, Bestatin

乌苯美司Chemical Name: (-)-N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine
CAS No. 58970-76-6
项目整合开发状态: Launched-1987
项目研究机构: Nippon Kayaku (Originator)
合成路线:The reaction of N-(2-oxo-2...
参考文献标题:Process for producing threo-3-amino-2-hydroxybutanoyl-aminoacetic acids,as well as novel intermediated therefor and process for producing them
文献作者:Umezawa,H.; Aoyagi,T.; Shirai,T.; Nishizawa,R.; Suzuki,M.; Saino,T.(Nippon Kayaku Co.,Ltd.)
参考来源:DE 2947140; ES 486572; FR 2442227; GB 2090595; US 4281180

Lobaplatin, D-19466

乐铂洛铂 Chemical Name: cis-[trans-1,2-Cyclobutanebis(methylamine)][(S)-lactato-O1,O2]platinum(II); cis-[(1R*,2R*)-1,2-Cyclobutanebis(methylamino)-N,N'][(2S)-2-hydroxypropanoato(2-)-O1,O2]platinum
CAS...
参考文献标题:D-19466,a new cyclobutane-platinum complex with antitumor activity
文献作者:Voegeli,R.; Schumacher,W.; Engel,J.; Respondek,J.; Hilgard,P.
参考来源:J Cancer Res Clin Oncol 1990,116(5),439-42

Efaproxiral sodium, RSR-13, Revaproxyn, Efaproxyn

乙丙昔罗钠乙丙昔罗 Chemical Name: 2-[4-(3,5-Dimethylphenylcarbamoylmethyl)phenoxy]-2-methylpropionic acid sodium salt
CAS No. 170787-99-2, 131179-95-8 (free acid)
项目整合开发状态: Pre-Registered
项目研究机构: All...
参考文献标题:Allosteric hemoglobin modifiers
文献作者:Abraham,D.J.; Mehanna,A.; Randad,R.; Mahran,M.
参考来源:US 5049695; WO 9112235

Ethyl carfluzepate, CM-7120

乙卡氟特Chemical Name: 7-Chloro-5-(2-fluorophenyl)-1-(N-methylcarbamoyl)-2-oxo-2,3-dihydro-1H-1,4-benzodiazepine-3-carboxylic acid ethyl ester
CAS No. 65400-85-3
项目整合开发状态: Not Determined
项目研究机构: ...
参考文献标题:
文献作者:Demarne,H.; Hallot,A.
参考来源:AU 356658; BE 854249; DE 2719608; FR 2350345; FR 2350346; GB 1538165; NL 7704911; NL 7704912

Bimolane, AT-1727

乙双吗啉Chemical Name: 4,4'-(1,2-Ethanediyl)bis[1-(4-morpholinyl)piperazine-2,6-dione]
CAS No. 74550-97-3
项目整合开发状态: Biological Testing
项目研究机构: Henan Medical University (Originator)
合成路线:Ethyle...
参考文献标题:An investigation of a new antineoplastic agent bimolane (AT-1727)
文献作者:Ren,Y.F.; et al.
参考来源:Kexue Tongbao 1980,23(4),189-190

Moracizine hydrochloride, Moricizine hydrochloride, E-350, E-313, Ethmozine

乙吗噻嗪Chemical Name: 10-(3-Morpholinopropionyl)phenothiazine-2-carbamic acid ethyl ester hydrochloride
CAS No. 31883-05-3 (free base)
项目整合开发状态: Launched-1979
项目研究机构: Bristol-Myers Squibb (Origi...
参考文献标题:Moracizine
文献作者:Castar,J.; Roberts,P.J.
参考来源:Drugs Fut 1978,3(2),122

Eclazolast, RHC-2871, REV-2871, CHBZ

乙唑司特Chemical Name: 2-Ethoxyethyl 5-chlorobenzoxazole-2-carboxylate; 5-Chloro-2-benzoxazolecarboxylic acid 2-ethoxyethyl ester
CAS No. 80263-73-6
项目整合开发状态: Phase II
项目研究机构: Aventis Pharma (Ori...
参考文献标题:Esters of benzoxa(thia)zole-2-carboxylic acids
文献作者:Brown,R.E.; St.Georgiev,V.; Loev,B.(USV Pharmaceutical Corp.)
参考来源:US 4298742