Eclazolast, RHC-2871, REV-2871, CHBZ
乙唑司特Chemical Name: 2-Ethoxyethyl 5-chlorobenzoxazole-2-carboxylate; 5-Chloro-2-benzoxazolecarboxylic acid 2-ethoxyethyl ester
CAS No. 80263-73-6
项目整合开发状态: Phase II
项目研究机构: Aventis Pharma (Originator)
合成路线:The reaction of 6-chloro-1,4-benzoxazine-2,3-dione (I) with SOCl2 and DMF in refluxing toluene gives 3,6-dichloro-1,4-benzoxazin-2-one (II),which is then treated with 2-ethoxyethanol (III) and Na2CO3 at 70 C.
📌 参考资料/链接：
参考文献标题:Esters of benzoxa(thia)zole-2-carboxylic acids
文献作者:Brown,R.E.; St.Georgiev,V.; Loev,B.(USV Pharmaceutical Corp.)
参考来源:US 4298742
📄 详细内容
合成路线:The reaction of 6-chloro-1,4-benzoxazine-2,3-dione (I) with SOCl2 and DMF in refluxing toluene gives 3,6-dichloro-1,4-benzoxazin-2-one (II),which is then treated with 2-ethoxyethanol (III) and Na2CO3 at 70 C.
参考文献标题:Eclazolast
文献作者:Chu,S.S.
参考来源:Drugs Fut 1988,13(5),406
产品链接: CAS No. 80263-73-6››