合成路线:The reaction of 3-aminodiphenylamine (I) with ethyl chloroformate (A) gives ethyl 3-anilinocarbanilate (II),which is cyclized by heating with S and I2 to yield ethyl phenothiazine-2-carbamate (III).The condensation of (III) with 3-chloropropionyl chloride (B) in refluxing toluene affords ethyl 10-(3-chloropropionyl)phenothiazine-2-carbamate (IV),which is finally condensed with refluxing morpholine (C).
参考文献标题:Ethyl 10-(beta-N-morpholinylpropionyl)phenthiazine-2-carbamate and the hydrochloride thereof and a method for preparing the same
文献作者:Gritsenko,A.N.; et al.
参考来源:GB 1269969
合成路线:The reaction of 3-aminodiphenylamine (I) with ethyl chloroformate (A) gives ethyl 3-anilinocarbanilate (II),which is cyclized by heating with S and I2 to yield ethyl phenothiazine-2-carbamate (III).The condensation of (III) with 3-chloropropionyl chloride (B) in refluxing toluene affords ethyl 10-(3-chloropropionyl)phenothiazine-2-carbamate (IV),which is finally condensed with refluxing morpholine (C).
参考文献标题:Ethyl 10-(beta-morpholinylpropionyl)phenthiazine-2-carbamate hydrochloride
文献作者:Gritsenko,A.N.; et al.
参考来源:US 3740395
合成路线:The reaction of 3-aminodiphenylamine (I) with ethyl chloroformate (A) gives ethyl 3-anilinocarbanilate (II),which is cyclized by heating with S and I2 to yield ethyl phenothiazine-2-carbamate (III).The condensation of (III) with 3-chloropropionyl chloride (B) in refluxing toluene affords ethyl 10-(3-chloropropionyl)phenothiazine-2-carbamate (IV),which is finally condensed with refluxing morpholine (C).
参考文献标题:Antiarhythmic pharmaceutical preparation containing ethyl 10-(beta-morpholylpropionyl) phenthiazine-2-carbamate hydrochloride
文献作者:Gritsenko,A.N.; et al.
参考来源:DE 2014201; US 3864487
合成路线:The reaction of 3-aminodiphenylamine (I) with ethyl chloroformate (A) gives ethyl 3-anilinocarbanilate (II),which is cyclized by heating with S and I2 to yield ethyl phenothiazine-2-carbamate (III).The condensation of (III) with 3-chloropropionyl chloride (B) in refluxing toluene affords ethyl 10-(3-chloropropionyl)phenothiazine-2-carbamate (IV),which is finally condensed with refluxing morpholine (C).
参考文献标题:Synthesis of ethmosine [hydrochloride of the ethyl ester of 10-(beta-morpholylpropionyl)phenothiazine-2-carbamic acid],a new antiarrhytmic preparation
文献作者:Gritsenko,A.N.; et al.
参考来源:Khim Farm Zh 1972,6(9),17-19
产品链接: CAS No. 31883-05-3››