Efaproxiral sodium, RSR-13, Revaproxyn, Efaproxyn
乙丙昔罗钠 乙丙昔罗 Chemical Name: 2-[4-(3,5-Dimethylphenylcarbamoylmethyl)phenoxy]-2-methylpropionic acid sodium salt
CAS No. 170787-99-2, 131179-95-8 (free acid)
项目整合开发状态: Pre-Registered
项目研究机构: Allos (Orphan Drug), Virginia Commonwealth University (Originator), Allos (Codevelopment)
合成路线:Reaction of 4-hydroxyphenylacetic acid (I) with refluxing SOCl2,followed by treatment of the resulting polymeric phenol ester with 3,5-dimethylaniline (II) in refluxing xylene provided amide (III).Condensation of this compound with acetone and chloroform in the presence of powdered NaOH yielded the corresponding isobutyric acid derivative.
📌 参考资料/链接：
参考文献标题:Allosteric hemoglobin modifiers
文献作者:Abraham,D.J.; Mehanna,A.; Randad,R.; Mahran,M.
参考来源:US 5049695; WO 9112235
📄 详细内容
合成路线:Reaction of 4-hydroxyphenylacetic acid (I) with refluxing SOCl2,followed by treatment of the resulting polymeric phenol ester with 3,5-dimethylaniline (II) in refluxing xylene provided amide (III).Condensation of this compound with acetone and chloroform in the presence of powdered NaOH yielded the corresponding isobutyric acid derivative.
参考文献标题:Allosteric modifiers of hemoglobin.1.Design,synthesis,testing,and structure-allosteric activity relationship of novel hemoglobin oxygen affinity decreasing agents
文献作者:Randad,R.S.; Mahran,M.A.; Mehanna,A.S.; Abraham,D.J.
参考来源:J Med Chem 1991,34(2),752
合成路线:Reaction of 4-hydroxyphenylacetic acid (I) with refluxing SOCl2,followed by treatment of the resulting polymeric phenol ester with 3,5-dimethylaniline (II) in refluxing xylene provided amide (III).Condensation of this compound with acetone and chloroform in the presence of powdered NaOH yielded the corresponding isobutyric acid derivative.
参考文献标题:Efaproxiral Sodium
文献作者:McIntyre,J.; Castar,J.
参考来源:Drugs Fut 2003,28(12),1159
产品链接: CAS No. 170787-99-2›› 产品链接: CAS No.131179-95-8››