其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Nitryl Chloride CAS Registry Number: 13444-90-1

Additional Names: Nitroxyl chloride
Percent Composition: Cl 43.52%, N 17.19%, O 39.28%
Literature References: Conveniently prepd by the addn of chlorosulfonic acid to nitric acid: Dachlauer, DE 509405 (1929 to I. G. Farben); Kaplan, Schechter, Inorg. Synth. 4, 52 (1953); Collis et al., J. Chem. Soc. 1958, 438.

Sodium Thiophosphate CAS Registry Number: 10101-88-9 硫代磷酸钠

Additional Names: Sodium phosphorothioate; sodium monothiophosphate
Percent Composition: Na 38.31%, O 26.66%, P 17.21%, S 17.81%
Literature References: Conveniently prepd from NaPO3 + Na2S: Zintl, Bertram, Z. Anorg. Allg. Chem. 245, 16 (1940); from PSCl3 + NaOH: Tridot, Tudo, Bull. Soc. Chim. Fr. 1960, 1231. Several alternate routes, e.g. from P2S5 and NaOH, see Klement in Handbook of Preparative Inorganic Chemistry vol. 1, G. Brauer, Ed. (Academic Press, New York, 2nd ed., 1963) pp 569-570.

Stryker's Reagent CAS Registry Number: 33636-93-0 三苯基磷酸亚酮六聚体

CAS Name: Octahedrohexa-m3-hydrohexakis(triphenylphosphine)hexacopper
Additional Names: hexa-m-hydrohexakis(triphenylphosphine) hexacopper; triphenylphosphine copper(I) hydride hexamer
Perce...
Literature References: Copper(I) hydride cluster; mild hydride donor in organic synthesis. Prepn and crystal characterization: S. A. Bezman et al., J. Am. Chem. Soc. 93, 2063 (1971); M. R. Churchill et al., Inorg. Chem. 11, 1818 (1972). Improved prepns: D. M. Brestensky et al., Tetrahedron Lett. 29, 3749 (1988); P. Chiu et al., ibid. 44, 455 (2003). Use in reduction of a,b-unsaturated carbonyl compds: W. S. Mahoney et al., J. Am. Chem. Soc. 110, 291 (1988); W. S. Mahoney, J. M. Stryker, ibid. 111, 8818 (1989); in hydrosilylation of aldehydes and ketones: B. H. Lipshutz et al., J. Organomet. Chem. 624, 367 (2001). Brief review: A. de Fátima, Synlett 2005, 1805-1806 (2005).

Trolnitrate Phosphate CAS Registry Number: 588-42-1 乙醇,2,2'-硝酸盐,三硝酸酯(酯),磷酸盐(12)(盐)(9CI)

CAS Name: 2,2'2''-Nitrilotrisethanol trinitrate (ester) phosphate (1:2) (salt)
Additional Names: triethanolamine trinitrate biphosphate; trinitrotriethanolamine diphosphate; tri(2-nitroxyethyl)...
Literature References: Coronary vasodilator. Prepd by the nitration of triethanolamine followed by precipitation with phosphoric acid: Metadiet, FR 984523 (1951); Junkmann et al., DE 830955 (1952 to Schering).

Isosorbide Dinitrate CAS Registry Number: 87-33-2 硝酸异山梨酯

CAS Name: 1,4:3,6-Dianhydro-D-glucitol dinitrate
Additional Names: dinitrosorbide; 1,4:3,6-dianhydrosorbitol 2,5-dinitrate
Trademarks: Carvasin (Teofarma); Cedocard (Pharmacia); Corovliss (R...
Literature References: Coronary vasodilator. Prepn from sorbitol: Goldberg, Acta Physiol. Scand. 15, 173 (1948), C.A. 42, 5564 (1948); Kochergin, Titkova, C.A. 54, 8647h (1960). Absorption and disposition in man: H. Laufen et al., Arzneim.-Forsch. 33, 980 (1983). Comprehensive description: L. A. Silvieri, N. J. DeAngelis, Anal. Profiles Drug Subs. 4, 225-244 (1975).

Trimetazidine CAS Registry Number: 5011-34-7 曲美他嗪

CAS Name: 1-[(2,3,4-Trimethoxyphenyl)methyl]piperazine
Percent Composition: C 63.13%, H 8.33%, N 10.52%, O 18.02%
Literature References: Coronary vasodilator. Prepn: Regnier, Canevari, FR 1302958 (1962 to Sci. Union et Cie, Soc. Franç. Rech. Med.); FR M805; J. Servier, US 3262852 (1961, 1966 to Biofarma). Pharmacology: Fujita, Jpn. J. Pharmacol. 17, 19 (1967); Nagata et al., ibid. 19, 628 (1969); 21, 337 (1971). GC-MS determn in biological fluids: L. Fay et al., J. Chromatogr. 490, 198 (1989). Review of pharmacology, toxicology and clinical studies: C. Harpey et al., Cardiovasc. Drug Rev. 6, 292-312 (1989).

Phytantriol CAS Registry Number: 74563-64-7 植烷三醇 (异构体混合物)

CAS Name: 3,7,11,15-Tetramethyl-1,2,3-hexadecanetriol
Additional Names: phytane-1,2,3-triol
Percent Composition: C 72.67%, H 12.81%, O 14.52%
Literature References: Cosmetic ingredient; improves moisture retention properties of hair and skin; acts as a penetration enhancer to increase the effects of panthenol, vitamins, and amino acids. Prepn: W. Guex et al., DE 1149700 (1963 to F. Hoffmann-La Roche); T. C. Jain, R. J. Striha, Can. J. Chem. 47, 4359 (1969). Cosmetic uses: E. Wagner, Parfuem. Kosmet. 75, 260 (1994). Aqueous phase behavior: J. Barauskas, T. Landh, Langmuir 19, 9562 (2003).

Dropropizine CAS Registry Number: 17692-31-8 羟丙哌嗪

CAS Name: 3-(4-Phenyl-1-piperazinyl)-1,2-propanediol
Additional Names: 1-phenyl-4-(2,3-dihydroxypropyl)piperazine; 1-(2,3-dihydroxypropyl)-4-phenylpiperazine; 1-phenyl-4-(2,3-dihydroxypropyl)di...
Literature References: Cough suppressive phenylpiperazine derivative. Prepn: H. G. Morren, BE 601394; eidem, US 3163649 (1961, 1964 to UCB); H. Howell et al., J. Org. Chem. 27, 1709 (1962); J. Bourdais, Bull. Soc. Chim. Fr. 1968, 3246. Prepn of enantiomers: M. Borsa et al., EP 147847; eidem, US 4699911 (1985, 1987 both to Dompé). LC-MS-MS determn in plasma: Y. Tang et al., J. Chromatogr. B 819, 185 (2005). Pharmacology: K. Cartwright, J. L. Paterson, J. Pharm. Pharmacol. 23, Suppl., 247S (1971). Controlled clinical trials: G. C. Moreo et al., Gazz. Med. Ital. 140, 409 (1981); A. Ravetta, M. Ravetta, ibid. 141, 531 (1982). Chronic oral toxicity: P. R. B. Noel, Arzneim.-Forsch. 19, 1246 (1969).

Peucedanin CAS Registry Number: 133-26-6 3-甲氧基-2-丙-2-基呋喃并[3,2-g]苯并吡喃-7-酮

CAS Name: 3-Methoxy-2-(1-methylethyl)-7H-furo[3,2-g][1]benzopyran-7-one
Additional Names: 6-hydroxy-2-isopropyl-3-methoxy-5-benzofuranacrylic acid d-lactone; 4-methoxy-5-isopropylfuro[2,3:6,7]c...
Literature References: Coumarin deriv obtained from rhizome of Peucedanum officinale L., Umbelliferae: Schlatter, Ann. 5, 201 (1833); Hlasiwetz, Weidel, ibid. 174, 67 (1874); A. Jassoy, P. Haensel, Arch. Pharm. 236, 662 (1898); Popper, Monatsh. Chem. 19, 268 (1898); from Peucedanum morisonii, Bess., Umbelliferae: G. K. Nikonov, A. A. Ivashenko, Zh. Obshch. Khim. 33, 2740 (1963). Fluorescence spectrum: R. H. Goodwin, F. Kavanagh, Arch. Biochem. 27, 182 (1950). Antitumor activity and toxicity studies: E. M. Vermel, S. A. Kruglyak-Syrkina, Vopr. Onkol. 5, 43 (1959), C.A. 53, 19162h (1959). Structure: E. Späth et al., Ber. 64, 2203 (1931); E. Späth, K. Klager, ibid. 66, 749 (1933). Synthesis: H. Schmid, A. Ebnöther, Helv. Chim. Acta 34, 1982 (1951).

Dicyclohexylcarbodiimide CAS Registry Number: 538-75-0 N,N'-二环己基碳酰亚胺

CAS Name: N,N'-Methanetetraylbiscyclohexanamine
Additional Names: carbodicyclohexylimide; DCC; DCCI
Percent Composition: C 75.67%, H 10.75%, N 13.58%
Literature References: Coupling agent in peptide synthesis: Sheehan, Hess, J. Am. Chem. Soc. 77, 1067 (1955); Khorana, Chem. Ind. (London) 1955, 1087. Prepn: Schmidt et al., Ber. 71, 1933 (1938); Schmidt, Schnegg, US 2656383 (1953 to Bayer); Stevens et al., J. Org. Chem. 32, 2895 (1967); Bestmann et al., Ann. 718, 24 (1968).