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Trimetazidine CAS Registry Number: 5011-34-7 曲美他嗪

CAS Name: 1-[(2,3,4-Trimethoxyphenyl)methyl]piperazine
Percent Composition: C 63.13%, H 8.33%, N 10.52%, O 18.02%

📌 参考资料/链接：
Literature References: Coronary vasodilator. Prepn: Regnier, Canevari, FR 1302958 (1962 to Sci. Union et Cie, Soc. Franç. Rech. Med.); FR M805; J. Servier, US 3262852 (1961, 1966 to Biofarma). Pharmacology: Fujita, Jpn. J. Pharmacol. 17, 19 (1967); Nagata et al., ibid. 19, 628 (1969); 21, 337 (1971). GC-MS determn in biological fluids: L. Fay et al., J. Chromatogr. 490, 198 (1989). Review of pharmacology, toxicology and clinical studies: C. Harpey et al., Cardiovasc. Drug Rev. 6, 292-312 (1989).

📄 详细内容

Properties: bp2 200-205°.
Boiling point: bp2 200-205°
Derivative Type: Dihydrochloride
CAS Registry Number: 13171-25-0
Trademarks: Kyurinett (Zensei); Vastarel F (Kyoto); Yoshimilon (Kowa Yakuhin)
Percent Composition: C 49.56%, H 7.13%, N 8.26%, O 14.15%, Cl 20.90%
Properties: Crystals, mp 225-228°. LD50 in male, female mice, rats (mg/kg): 91, 107, 124, 124 i.v.; 264, 245, 327, 288 i.p.; 528, 608, 1147, 987 orally (Harpey).
Melting point: mp 225-228°
Toxicity data: LD50 in male, female mice, rats (mg/kg): 91, 107, 124, 124 i.v.; 264, 245, 327, 288 i.p.; 528, 608, 1147, 987 orally (Harpey)
Therap-Cat: Antianginal.
Keywords: Vasodilator (Coronary).
产品链接: 5011-34-7››

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