其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

EEDQ CAS Registry Number: 16357-59-8 2-乙氧基-1-乙氧碳酰基-1,2-二氢喹啉

CAS Name: 2-Ethoxy-1(2H)-quinolinecarboxylic acid ethyl ester
Additional Names: N-carbethoxy-2-ethoxy-1,2-dihydroquinoline; N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinolinePercent Composition: C ...
Literature References: Coupling agent used in the synthesis of peptides: Belleau, Malek, J. Am. Chem. Soc. 90, 1651 (1968); Yajima, Kawatani, Chem. Pharm. Bull. 19, 1905 (1971); Sipos, Gaston, Synthesis 1971, 321. Preparation: Weinberg, US 3389142 and US 3452140 (1968, 1969, to Bristol-Myers). Has CNS depressant activity: Belleau, J. Am. Chem. Soc. 90, 823 (1968). Pharmacological studies: Martel et al., Can. J. Physiol. Pharmacol. 47, 909 (1969); Chang et al., Pharmacol. Res. Commun. 2, 63 (1970); Weissman, Muren, J. Med. Chem. 14, 49 (1971).

Acibenzolar-S-methyl CAS Registry Number: 135158-54-2 阿拉酸式苯-S-甲基(活化酯)

CAS Name: 1,2,3-Benzothiadiazole-7-carbothioic acid S-methyl ester
Additional Names: 7-(methylthiocarbonyl)-benzo-1,2,3-thiadiazoleTrademarks: Bion (Syngenta)
Percent Composition: C 45.69%, ...
Literature References: Crop protection agent which activates the natural plant response to infection, known as systemic aquired resistance (SAR). Prepn: R. Schurter et al., EP 313512; eidem, US 5523311 (1989, 1996 both to Ciba-Geigy). Properties and biological activity: W. Ruess et al., Brighton Crop Prot. Conf. - Pests Dis. 1996, 53. Mode of action: H. Kessman et al. ibid. 961. Use as a seed treatment: B. D. Jensen et al., Pestic. Sci. 52, 63 (1998).

Sodium Succinate CAS Registry Number: 150-90-3 丁二酸钠

Additional Names: Succinic acid sodium salt; disodium succinate
Percent Composition: C 29.65%, H 2.49%, Na 28.37%, O 39.49%
Literature References: Crystal structure of hexahydrate: I. Fonseca et al., Acta Crystallogr. C42, 1123 (1986). Acute toxicity and clinical experience: M. Zuckerbrod, I. Graef, Ann. Intern. Med. 32, 905 (1950).

Cotoin CAS Registry Number: 479-21-0 柯托苷; 2,6-二羟基-4-甲氧基二苯甲酮

CAS Name: (2,6-Dihydroxy-4-methoxyphenyl)phenylmethanone
Additional Names: 2,6-dihydroxy-4-methoxybenzophenone
Percent Composition: C 68.85%, H 4.95%, O 26.20%
Literature References: Crystalline principle from true coto bark, the bark of Aniba coto (Rusby) Kost, Lauraceae. Extraction procedure: Jobst, Hesse, Ann. 199, 17 (1879). Isoln from South American rosewood trees, Aniba rosaeodora Ducke and A. duckei Kost. Lauraceae: Gottlieb, Mors, J. Am. Chem. Soc. 80, 2263 (1958). Structure: Karrer, Lichtenstein, Helv. Chim. Acta 11, 789 (1928). Toxicity study: Jodbauer, Kurz, Biochem. Z. 74, 340 (1916).

Potassium Tetracyanoplatinate(II) CAS Registry Number: 562-76-5 四氰基铂酸钾(II)水合物

CAS Name: Dipotassium tetrakis(cyano-C)platinate(2-)
Additional Names: platinous potassium cyanide; potassium platinocyanide
Percent Composition: C 12.73%, K 20.72%, N 14.85%, Pt 51.70%
Literature References: Crystallizes as a tri- or a dodecahydrate.

Thorium Sulfate CAS Registry Number: 10381-37-0

Percent Composition: O 30.18%, S 15.12%, Th 54.71%
Literature References: Crystallizes with 4, 6, 8 and 9 mols H2O.

Sodium Phosphate, Tribasic CAS Registry Number: 7601-54-9 磷酸三钠

Additional Names: Trisodium orthophosphate; trisodium phosphate; TSP
Trademarks: Oakite
Percent Composition: Na 42.07%, O 39.04%, P 18.89%
Literature References: Crystallizes with 8 and 12 mols of H2O.

Gallamine Triethiodide CAS Registry Number: 65-29-2 加拉碘铵

CAS Name: 2,2',2''-[1,2,3-Benzenetriyltris(oxy)]tris[N,N,N-triethylethanaminium] triiodide
Additional Names: [n-phenenyltris(oxyethylene)]tris[triethylammonium triiodide]; 1,2,3-tris(2-triethyl...
Literature References: Curarizing properties: D. Bovet et al., Compt. Rend. 225, 74 (1947); F. Depierre, ibid. 956. Prepn: E. Fourneau, US 2544076 (1951 to Rhone-Poulenc). Comparative clinical pharmacokinetics: W. Buzello, S. Agoston, Anaesthesist 27, 313 (1978). Mode of action: D. Colquhoun, R. E. Sheridan, Br. J. Pharmacol. 66, 78 (1979); eidem, Proc. R. Soc. London Ser. B 211, 181 (1981). Effects in mammalian and amphibian nerve fibers: K. J. Smith, C. L. Schauf, Science 212, 1170 (1981).

Pradofloxacin CAS Registry Number: 195532-12-8 普拉沙星

CAS Name: 8-Cyano-1-cyclopropyl-6-fluoro-1,4-dihydro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid
Additional Names: 8-cyano-1-cyclopropyl-7-((1S,6S)-2,...
Literature References: Cyanofluorinated quinoline antibiotic. Prepn: S. Bartel et al., WO 9731001; eidem, US 6323213 (1997, 2001 both to Bayer). LC/MS/MS determn in biological fluids: R. Krebber, J. Vet. Pharmacol. Ther. 26, Suppl 1, 102 (2003). Bioavailability: M. A. Bregante et al., ibid. 87; K. Fraatz et al., ibid. 88. Clinical trial in dogs in comparison with amoxicillin and clavulanic acid, q.q.v.: B. Stephan et al., ibid. 217.

Letosteine CAS Registry Number: 53943-88-7 来托司坦

CAS Name: 2-[2-[(2-Ethoxy-2-oxoethyl)thio]ethyl]-4-thiazolidinecarboxylic acid
Additional Names: 2-[2-[(carboxymethyl)thio]ethyl]-4-thiazolidinecarboxylic acid 2-ethyl ester
Trademarks: Visc...
Literature References: Cyclic cysteine derivative. Prepn: M. X. Chodkiewicz, DE 2410307; eidem, US 4032534 (1974, 1979 to Ferlux-Chemie). Effect on viscoelasticity of mucus: E. Puchelle et al., Eur. J. Respir. Dis. 61 (Suppl 110), 195 (1980). In treatment of bronchitis: V. Macquet et al., Lille Med. 24, 735 (1979); P. Freour, J. Vergeret, Bordeaux Med. 12, 1553 (1979); P. Freour, ibid. 13, 1431 (1980); P. Meroni et al., Clin. Ter. 105, 109 (1983). Comparison with sulfur-containing compounds in bronchitis: D. Rodde, C.R. Ther. Pharmacol. Clin. 1(5), 31 (1983).