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项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Juglone CAS Registry Number: 481-39-0 胡桃酮,5-羟基对萘醌

CAS Name: 5-Hydroxy-1,4-naphthalenedione
Additional Names: 5-hydroxy-1,4-naphthoquinone; 8-hydroxy-1,4-naphthoquinone; C.I. 75500; C.I. Natural Brown 7; nucin; regianin
Percent Composition: ...
Literature References: Coloring matter occurring in various Juglandaceae spp: Brissemoret, Combes, Compt. Rend. 141, 838 (1905). Isoln from walnut shells: Combes, Bull. Soc. Chim. 1(4), 800 (1907). Isoln and description of sedative properties in fish, mammals: B. A. Westfall et al., Science 134, 1617 (1961). Isoln from pecans and identification as inhibitory agent of mycelial growth of Fusicladium effusum: P. A. Hedin et al., J. Agric. Food Chem. 28, 340 (1980). Synthesis: Bernthsen, Semper, Ber. 20, 938 (1887); Willstätter, Wheeler, Ber. 47, 2798 (1914); Teuber, Götz, Ber. 87, 1236 (1954); C. Grundmann, Synthesis 1977, 644. Tumor-promoting activity study: B. L. Van Duuren et al., J. Med. Chem. 21, 26 (1978). Use as pH indicator: S. S. Sawhney, B. M. L. Bhatia, J. Indian Chem. Soc. 57, 438 (1980).

Monardein Chloride CAS Registry Number: 1329-77-7

Additional Names: Monardaein chloride; pelargonidin-3-(6-p-coumaroyl)glucosido-5-glucoside chloride
Percent Composition: C 55.64%, H 4.80%, Cl 4.56%, O 35.00%
Literature References: Coloring matter of Monarda didyma L. ("golden balm"), Labiatae: Karrer, Widmer, Helv. Chim. Acta 10, 67 (1927); Karrer, ibid. 11, 837 (1928). Structure: Birkofer et al., Z. Naturforsch. 20b, 424 (1965).

Carthamin CAS Registry Number: 36338-96-2 红花黄色素

CAS Name: (2Z,6S)-6-b-D-Glucopyranosyl-2-[[(3S)-3-b-D-glucopyranosyl-2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-6-oxo-1,4-cyclohexadien-1-yl]methylene]-5,6-dihydroxy-4-[(2E)-3-...
Literature References: Coloring principle from safflower, Carthamus tinctorius L., Compositae. Purification and review of early efforts: T. Kametaka, A. G. Perkin, J. Chem. Soc. 97, 1415 (1910). Structure: C. Kuroda, J. Chem. Soc. 1930, 752, 765. Revised structure: H. Obara, J. Onodera, Chem. Lett. 1979, 201. Absolute configuration: S. Sato et al., ibid. 1996, 833. Total synthesis as acetate: S. Sato et al., ibid. 2001, 1318. Biogenesis: M. Shimokoriyama, S. Hattori, Arch. Biochem. Biophys. 54, 93 (1955). Determn of levels in Carthamus Red: T. Morimoto et al., Nippon Shokuhin Kagaku Gakkaishi 5, 236 (1998). Color stability in aqueous soln: J.-B. Kim, Y.-S. Paik, Arch. Pharmacal Res. 20, 643 (1997); with polysaccharides: K. Saito, Acta. Bot. Croat. 57, 123 (1998). Review of prepn protocols: K. Saito, Y. Fukaya, Acta Alimentaria 26, 141-152 (1997). See also: Colour Index vol. 4 (3rd ed., 1971) p 4625.

Ferric Albuminate CAS Registry Number: 8001-11-4

Additional Names: Albumized iron
Literature References: Combinations of egg albumin and iron contg 17-19% Fe. The exact form in which iron exists in these compds is not known and probably varies with the method of manuf. Structure and composition of compds of Fe and albumin: Heymann, Oppenheimer, Biochem. Z. 199, 468 (1928).

Iloperidone CAS Registry Number: 133454-47-4 伊潘立酮

CAS Name: 1-[4-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanoneTrademarks: Zomaril (Novartis)
Percent Composition: C 67.59%, H 6.38%, F 4.45%, N 6.57%, O 1...
Literature References: Combined dopamine (D2) and serotonin (5HT2) receptor antagonist. Prepn: J. T. Strupczewski et al., EP 402644; eidem, US 5364866 (1990, 1994 both to Hoechst-Roussel); eidem, J. Med. Chem. 38, 1119 (1995). Pharmacology: M. R. Szewczak et al., J. Pharmacol. Exp. Ther. 274, 1404 (1995). Clinical pharmacokinetics: S. M. Sainati et al., J. Clin. Pharmacol. 35, 713 (1995). HPLC determn in plasma: A. E. Mutlib, J. T. Strupczewski, J. Chromatogr. B 669, 237 (1995). Receptor binding study: S. Kongsamut et al., Eur. J. Pharmacol. 317, 417 (1996). Review of pharmacology and therapeutic potential in schizophrenia: J. M. K. Hesselink, Curr. Opin. Cent. Peripher. Nerv. Syst. Invest. Drugs 2, 71-78 (2000); K. K. Jain, Expert Opin. Invest. Drugs 9, 2935-2943 (2000).

Ziprasidone CAS Registry Number: 146939-27-7 齐拉西酮

CAS Name: 5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one
Additional Names: 5-(2-(4-(1,2-benzisothiazol-3-yl)piperazinyl)ethyl)-6-chlorooxindolePercen...
Literature References: Combined serotonin (5HT2) and dopamine (D2) receptor antagonist. Prepn: J. A. Lowe III, A. A. Nagel, EP 281309; eidem, US 4831031 (1988, 1989 both to Pfizer). Clinical pharmacology: C. J. Bench et al., Psychopharmacology 112, 308 (1993). HPLC determn in serum: J. S. Janiszewski et al., J. Chromatogr. B 668, 133 (1995). Receptor binding profile: A. W. Schmidt et al., Eur. J. Pharmacol. 425, 197 (2001). Review of pharmacology and clinical experience: G. L. Stimmel et al., Clin. Ther. 24, 21-37 (2002); P. D. Harvey, C. R. Bowie, Expert Opin. Pharmacother. 6, 337-346 (2005).

Asenapine CAS Registry Number: 65576-45-6 阿塞那平

CAS Name: (3aR,12bR)-rel-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole
Percent Composition: C 71.45%, H 5.64%, Cl 12.41%, N 4.90%, O 5.60%
Literature References: Combined serotonin (5HT2) and dopamine (D2) receptor antagonist; structurally related to mianserin, q.v. Prepn: BE 854915 (1977 to Akzo); W. J. van der Burg, US 4145434 (1979 to Akzona). Synthesis of labelled compd: J. Vader et al., J. Labelled Compd. Radiopharm. 34, 845 (1994). Series of articles on properties, metabolism and pharmacology: Arzneim.-Forsch. 40, 536-554 (1990). Receptor binding study: E. Richelson, T. Souder, Life Sci. 68, 29 (2000). Clinical pharmacology: B. Andrée et al., Psychopharmacology 131, 339 (1997). Review of development and therapeutic potential: J. J. Miguel-Hidalgo, Curr. Opin. Cent. Peripher. Nerv. Syst. Invest. Drugs 2, 85-92 (2000).

Ridogrel CAS Registry Number: 110140-89-1 利多格雷

CAS Name: 5-[[(E)-[3-Pyridinyl[3-(trifluoromethyl)phenyl]methylene]amino]oxy]pentanoic acidPercent Composition: C 59.02%, H 4.68%, F 15.56%, N 7.65%, O 13.10%
Literature References: Combined thromboxane A2 synthase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor antagonist. Prepn: E. J. E. Freyne et al., EP 221601; eidem, US 4963573 (1987, 1990 both to Janssen). Clinical pharmacology: B. Hoet et al., Thromb. Haemostasis 64, 87 (1990); C. Weber et al., ibid. 68, 214 (1992). Clinical study in peripheral arterial obstructive disease: J. De Cree et al., Int. Angiol. 12, 59 (1993); as adjunct to thrombolysis in acute myocardial infarction: RAPT Investigators, Circulation 89, 588 (1994).

Thorium Nitrate CAS Registry Number: 13823-29-5 硝酸钍水合物

Percent Composition: N 11.67%, O 39.99%, Th 48.34%
Literature References: Commercial form obtained as tetrahydrate; also crystallizes with 6 and 12 mols H2O. Obtained from monazite: Pearce et al., Inorg. Synth. II, 38 (1946).

Ammonium Thiocyanate CAS Registry Number: 1762-95-4 硫氰酸铵分析滴定液

CAS Name: Thiocyanic acid ammonium salt
Additional Names: ammonium rhodanide; ammonium sulfocyanate; ammonium sulfocyanide
Percent Composition: C 15.78%, H 5.30%, N 36.80%, S 42.12%
Literature References: Commercial grade is 98-99% pure. Prepn: Gmelins, Ammonium (8th ed.) 23, pp 372-383 (1936). Review of toxicology and human exposure: Toxicological Profile for Cyanide (PB98-101207, 1997) 291 pp.