其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Pseudococaine CAS Registry Number: 478-73-9 8-氮杂双环[3.2.1]辛烷-2-羧酸,3-(苯甲氧基)-8-甲基,甲基酯,(1R,2S,3S,5S)-

CAS Name: [1R-(2-endo,3-exo)]-3-(Benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl ester
Additional Names: 3b-hydroxy-1aH,5aH-tropane-2a-carboxylic acid methyl ester benzo...
Literature References: Cocaine diastereomer with greater local anesthetic activity than the natural substance. Synthesis: Einhorn, Marquardt, Ber. 23, 468, 981 (1890); Willstätter, Bode, Ann. 326, 42 (1903); Willstätter, Bommer, ibid. 422, 34 (1921); Willstätter et al., ibid. 434, 138 (1923); GB 210050 (1923 to E. Merck). Configuration: S. P. Findlay, J. Am. Chem. Soc. 76, 2855 (1954). Conformational analysis and 1H, 13C NMR studies: F. I. Carroll et al., J. Org. Chem. 1982, 13. Pharmacokinetics: A. L. Misra et al., Experientia 32, 895 (1976). Interaction with sodium channels: J C. Matthews, A. Collins, Biochem. Pharmacol. 32, 455 (1983). Pharmacology of cocaine and pseudococaine: G. Schmidt et al., Arch. Exp. Pathol. Pharmakol. 240, 523 (1961).

Benzoylecgonine CAS Registry Number: 519-09-5 苯甲酰芽子碱标准液

CAS Name: 3-(Benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid
Additional Names: 3b-hydroxy-1aH,5aH-tropane-2b-carboxylic acid benzoate; ecgonine benzoate
Percent Composition:...
Literature References: Cocaine metabolite. Isoln from coca leaves: De Jong, Rec. Trav. Chim. 42, 980 (1923). Prepn from l-ecgonine and benzoic anhydride: idem, ibid. 66, 544 (1947).

Thiamine Diphosphate CAS Registry Number: 154-87-0 焦磷酸硫胺素

CAS Name: 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-4-methyl-5-(4,6,6-trihydroxy-3,5-dioxa-4,6-diphosphahex-1-yl)thiazolium chloride P,P'-dioxide
Additional Names: thiamine trihydrogen pyropho...
Literature References: Coenzyme required for the decarboxylation of a-keto acids. Most abundant form of thiamine in animal tissues. Identification as cofactor and enzymatic synthesis: K. Lohmann, P. Schuster, Biochem. Z. 294, 183 (1937). Chemical synthesis: Weijlard, Tauber, J. Am. Chem. Soc. 60, 2263 (1938); Weil-Malherbe, Biochem. J. 34, 980 (1940); Weijlard, J. Am. Chem. Soc. 63, 1160 (1941); Karrer, Viscontini, Helv. Chim. Acta 29, 711 (1946). LC determn in blood: J. W. I. Brunnekreeft et al., J. Chromatogr. 491, 89 (1989). Role in pathogenesis of Wernicke-Korsakoff Syndrome: R. F. Butterworth et al., Alcohol. Clin. Exp. Res. 17, 1084 (1993). Review of enzyme activity: J. Ullrich et al., Vitam. Horm. 28, 365 (1970); of mechanism of action: R. Kluger, Chem. Rev. 87, 863-876 (1987); M. Louloudi, N. Hadjiliadis, Coord. Chem. Rev. 135, 429-468 (1994).

Adenosine Triphosphate CAS Registry Number: 56-65-5 5'-三磷酸腺苷

CAS Name: Adenosine 5'-(tetrahydrogen triphosphate)
Additional Names: ATP; adenosine 5'-triphosphoric acid
Trademarks: Adetol (Kyowa); Atriphos (Biochimica); Striadyne (Am. Home); Triadenyl ...
Literature References: Coenzyme valuable in the transfer of phosphate bond energy. Mammalian skeletal muscle at rest contains 350-400 mg ATP per 100 g. Upon stimulation of the muscle the ATP is hydrolyzed to ADP by the myosin-actin complex unless hydrolysis is prevented by injection of magnesium sulfate. Isoln from rabbit muscle: LePage, Biochem. Prep. 1, 5 (1949); cf. Fiske, Subbarow, Science 70, 381 (1929); Lohmann, Biochem. Z. 223, 460 (1931); 254, 381 (1932); Barrenscheen, Filz, ibid. 250, 281 (1932); Kerr, J. Biol. Chem. 139, 121 (1941); Needham, Biochem. J. 36, 113 (1942). Synthetic routes: Tanaka, Honjo, US 3079379 (1963 to Takeda). Reviews of biosynthesis: Racker, Adv. Enzymol. 23, 323-399 (1961); Deamer, J. Chem. Educ. 46, 198-206 (1971). Reviews of nucleotide coenzymes: Bock in The Enzymes vol. 2A, P. D. Boyer et al., Eds. (Academic Press, New York, 2nd ed., 1960) pp 3-38; A. M. Michelson, The Chemistry of Nucleosides and Nucleotides (Academic Press, New York, 1963) pp 153-250; D. W. Hutchinson, Nucleotides and Coenzymes (John Wiley, New York, 1964) pp 36-82.

Aniracetam CAS Registry Number: 72432-10-1 阿尼西坦

CAS Name: 1-(4-Methoxybenzoyl)-2-pyrrolidinone
Additional Names: 1-p-anisoyl-2-pyrrolidinoneTrademarks: Draganon (Roche); Sarpul (Roche)
Percent Composition: C 65.74%, H 5.98%, N 6.39%, O 21...
Literature References: Cognition enhancer related to piracetam, q.v. Prepn: JP Kokai 79 117468; E. Kyburz, W. Aschwanden, US 4369139 (1979, 1983 both to Hoffmann-La Roche). Effects on learning and memory in rats: R. Cumin et al., Psychopharmacology 78, 104 (1982); K. Yamada et al., Pharmacol. Biochem. Behav. 22, 645 (1985); in monkeys and pigeons: M. J. Pontecorvo, H. L. Evans, ibid. 745. Clinical evaluation in geriatric patients: P. Foltyn et al., Arzneim.-Forsch. 33, 865 (1983); in Alzheimer's disease: L. B. Sourander et al., Psychopharmacology 91, 90 (1987). Review of toxicology: B. Schläppi et al., Drug Invest. 5, Suppl. 1, 50-67 (1993).

Pramiracetam CAS Registry Number: 68497-62-1 普拉西坦

CAS Name: N-[2-[Bis(1-methylethyl)amino]ethyl]-2-oxo-1-pyrrolidineacetamide
Additional Names: N-[2-(diisopropylamino)ethyl]-2-oxo-1-pyrrolidineacetamide; amacetam
Percent Composition: C 62.4...
Literature References: Cognition enhancer structurally related to piracetam, q.v. Prepn: Y. J. L'Italien, I. C. Nordin, DE 2808067; eidem, US 4145347 (1978, 1979 both to Parke, Davis); D. E. Butler et al., J. Med. Chem. 27, 684 (1984). Pharmacology: B. P. H. Poschel et al., Drugs Exp. Clin. Res. 9, 853 (1983). GC determn in plasma: T. Chang, R. M. Young, J. Chromatogr. 274, 346 (1983). Clinical pharmacokinetics: T. Chang et al., J. Clin. Pharmacol. 25, 291 (1985). Clinical evaluation in Alzheimer's disease: R. J. Branconnier et al., Psychopharmacol. Bull. 19, 726 (1983); in various cognitive disorders: R. Dejong, Curr. Ther. Res. 41, 254 (1987).

Nebracetam CAS Registry Number: 97205-34-0 4-(氨甲基)-1-苄基吡咯烷-2-酮

CAS Name: 4-(Aminomethyl)-1-(phenylmethyl)-2-pyrrolidinone
Additional Names: (±)-4-(aminomethyl)-1-benzyl-2-pyrrolidinonePercent Composition: C 70.56%, H 7.89%, N 13.71%, O 7.83%
Literature References: Cognition enhancer with cholinergic and cytoprotectant activity. Prepn: K. H. Weber et al., DE 3336024; eidem, US 4833140 (1985, 1989, both to Boehringer, Ing.). Pharmacology: F. J. Kuhn et al., Arch. Int. Pharmacodyn. Ther. 292, 13 (1988). Toxicology: T. Yabe et al., Oyo Yakuri 44, 417 (1992), C.A. 117, 245471s (1992). Clinical effect on cognitive processes: T. F. Münte et al., Neuropsychobiology 19, 158 (1988). Clinical evaluation in Alzheimer's disease: K. Urakami et al., Clin. Neuropharmacol. 16, 347 (1993).

Exifone CAS Registry Number: 52479-85-3 依昔苯酮

CAS Name: (2,3,4-Trihydroxyphenyl)(3,4,5-trihydroxyphenyl)methanone
Additional Names: 2,3,3',4,4',5'-hexahydroxybenzophenone; 4-galloylpyrogallol
Trademarks: Adlone (Pharmascience)
Percen...
Literature References: Cognition enhancing agent. Prepn: H. Bleuler, A. G. Perkin, J. Chem. Soc. 109, 529 (1916); see also DE 49149 (1889 to BASF). Prepd but not claimed: J. M. Gazave et al., DE 2501443; eidem, US 4015017 (1975, 1977 both to Pharmascience). Pharmacology: R. D. Porsolt et al., Arzneim.-Forsch. 37, 388 (1987). Animal studies in memory improvement: R. D. Porsolt et al., Pharmacol. Biochem. Behav. 27, 253 (1987); in antagonism of benzodiazepine-induced amnesia: R. D. Porsolt et al., Psychopharmacology 95, 291 (1988). Clinical evaluation in senile dementia: F. Piette et al., Rev. Geriatr. 11, 375 (1986); in Parkinson's disease: H. Allain et al., Fundam. Clin. Pharmacol. 2, 1 (1988).

Plicatic Acid CAS Registry Number: 16462-65-0 大侧柏酸

CAS Name: (1S,2S,3R)-1-(3,4-Dihydroxy-5-methoxyphenyl)-1,2,3,4-tetrahydro-2,3,7-trihydroxy-3-(hydroxymethyl)-6-methoxy-2-naphthalenecarboxylic acid
Percent Composition: C 56.87%, H 5.25%, O 37....
Literature References: Coloring constituent and agent associated with western red cedar asthma. Low-molecular weight lignan which occurs as the (-)-form. Isolation from the heartwood of western red cedar, Thuja plicata Donn: J. A. F. Gardner et al., Can. J. Chem. 37, 1703 (1959). Structure determn: idem et al., ibid. 44, 52 (1966). Absolute configuration: R. J. Swan et al., ibid. 45, 319 (1967). Chromatographic analysis: B. F. MacDonald, E. P. Swan, J. Chromatogr. 51, 553 (1970). Identification as coloring material: Y. Kai, E. P. Swan, Mokuzai Gakkaishi 36, 218 (1990). Role in asthma: M. Chan-Yeung et al., Am. Rev. Respir. Dis. 108, 1094 (1973); eidem, J. Allergy Clin. Immunol. 79, 792 (1987). Mechanism of action study: M. Chan-Yeung, Am. J. Ind. Med. 25, 13 (1994).

Annatto CAS Registry Number: 1393-63-1 胭脂树橙

CAS Name: C.I. Natural Orange 4
Additional Names: C.I. 75120; arnotta; annotta
Literature References: Coloring matter from seeds of Bixa orellana L., Bixaceae. Extraction from seed: Barnett, Espoy, US 2815287 (1957); Kocher, US 2831775 (1958). Contains bixins, q.v., and several other yellow to orange-red pigments which give carotene reactions: Diemair et al., Naturwissenschaften 39, 211 (1933). Review of chemistry and applications: P. Collins, Food Ingred. Proc. Int. 13, 23-27 (1992). See also: Colour Index vol. 3 (3rd ed., 1971) p. 3233.