其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Perfluorohexane CAS Registry Number: 355-42-0 全氟己烷

CAS Name: Tetradecafluorohexane
Additional Names: perfluoro-n-hexane
Trademarks: Imavist (Schering AG)
Percent Composition: C 21.32%, F 78.68%
Literature References: Commercial grade perfluorohexanes contain a mixture of five acyclic C6F14 isomers and two C6F12 perfluorinated cyclic alkanes. Discovery: J. H. Simons, L. P. Block, J. Am. Chem. Soc. 59, 1407 (1937). Prepn and physical properties: V. E. Stiles, G. H. Cady, ibid. 74, 3771 (1952); R. D. Dunlap et al., ibid. 80, 83 (1958). Critical properties and virial coefficients: Z. L. Taylor, Jr., T. M. Reed, III, AIChE J. 16, 738 (1970). Conformational analysis: P. Piaggio et al., J. Mol. Struct. 26, 421 (1975). 19F-NMR characterization of commercial product: T. A. Kestner, J. Fluorine Chem. 36, 77 (1987). Use as a solvent in bromination reactions: S. M. Pereira et al., Synth. Commun. 25, 1023 (1995). Evaluation in acute lung injury in rabbits: M. Hübler et al., Crit. Care Med. 30, 422 (2002).

Diacetin CAS Registry Number: 25395-31-7 二乙酸甘油酯

CAS Name: 1,2,3-Propanetriol diacetate
Additional Names: glycerol diacetate; glyceryl diacetate
Percent Composition: C 47.72%, H 6.87%, O 45.41%
Literature References: Commercial material is probably a mixture of glycerol 1,2- and 1,3-diacetates. Prepn of the 1,2- and 1,3-compounds: Wegscheider, Zmerzlikar, Monatsh. Chem. 34, 1061 (1913); of the 1,2-compd: Golendeev, J. Gen. Chem. USSR 6, 1841 (1936); of the 1,3-compd: Lagenbeck, Bollow, Naturwissenschaften 42, 389 (1955).

Methoxychlor CAS Registry Number: 72-43-5 甲氧滴滴涕

CAS Name: 1,1'-(2,2,2-Trichloroethylidene)bis[4-methoxybenzene]
Additional Names: 1,1,1-trichloro-2,2-bis(p-methoxyphenyl)ethane; 2,2-di-p-anisyl-1,1,1-trichloroethane; DMDT; methoxy-DDT
Tra...
Literature References: Commercial prepn by the condensation of anisole with chloral in the presence of sulfuric acid: Schneller, Smith, Ind. Eng. Chem. 41, 1027 (1949). Activity: P. Läuger et al., Helv. Chim. Acta 27, 892 (1944). Toxicity study: H. C. Hodge et al., J. Pharmacol. Exp. Ther. 99, 140 (1950). Review of toxicology and human exposure: Toxicological Profile for Methoxychlor (PB2003-100140, 2002) 290 pp.

Lithium Triethylborohydride CAS Registry Number: 22560-16-3 三乙基硼氢化锂

CAS Name: (T-4)-Lithium triethylhydroborate(1-)
Trademarks: Super-Hydride (Aldrich)
Percent Composition: C 68.02%, H 15.22%, B 10.20%, Li 6.55%
Literature References: Commercial product is available in THF solution. Prepn: H. C. Brown et al., J. Am. Chem. Soc. 75, 192 (1953); P. Binger et al., Ann. 717, 21 (1968); H. C. Brown et al., Inorg. Chem. 16, 2229 (1977). Mechanism of reduction of organic halides: E. C. Ashby et al., J. Org. Chem. 49, 4505 (1984). Use as a reducing agent in organic and inorganic synthesis: H. C. Brown et al., J. Org. Chem. 45, 1 (1980); S. Krishnamurthy, H. C. Brown, ibid. 48, 3085 (1983); H. C. Brown, S.-C. Kim, ibid. 49, 1064 (1984); B. E. Blough, F. I. Carroll, Tetrahedron Lett. 34, 7239 (1993); C. K. Yee et al., Langmuir 15, 3486 (1999); H. Tanaka, K. Ogasawara, Tetrahedron Lett. 43, 4417 (2002).

Dipropylene Glycol Monomethyl Ether CAS Registry Number: 34590-94-8 二丙二醇甲醚

CAS Name: 1(or 2)-(2-Methoxymethylethoxy)propanol
Additional Names: DPGME; DPM
Trademarks: Arcosolv DPM (Arco); Dowanol DPM (Dow); Poly-Solv DPM (Olin)
Percent Composition: C 56.73%, H 10...
Literature References: Commercial product, prepd from propylene oxide and methanol, may consist of as many as four structural isomers. Prepn of major isomer, 1-(2-methoxy-1-methylethoxy)-2-propanol, depicted below: A. R. Sexton, E. C. Britton, J. Am. Chem. Soc. 75, 4357 (1953). GC determn in urine: B. Hubner et al., Fresenius J. Anal. Chem. 342, 746 (1992). Toxicity studies: H. F. Smyth, Jr. et al., Am. Ind. Hyg. Assoc. J. 23, 95 (1962); T. D. Landry, B. L. Yano, Fundam. Appl. Toxicol. 4, 612 (1984). Review of toxicology: Patty's Industrial Hygiene and Toxicology vol. 2D, G. D. Clayton, F. E. Clayton, Eds. (Wiley-Interscience, New York, 4th ed., 1994) pp 2882-2886; G. Johansson, NEG and NIOSH Basis for an Occupational Health Standard: Propylene Glycol Ethers and Their Acetates (PB91-220749, 1991) 47 pp.

p-Phenolsulfonic Acid CAS Registry Number: 98-67-9 对羟基苯磺酸

CAS Name: 4-Hydroxybenzenesulfonic acid
Additional Names: sulfocarbolic acid
Percent Composition: C 41.38%, H 3.47%, O 36.74%, S 18.41%
Literature References: Commercially available as a 65% soln. Prepn by hydrolysis of p-chloro- or p-bromobenzenesulfonic acid: Zollinger, Roehling, US 1321271 (1920); by sulfonation of phenol: Davidson, Byrne, GB 820659 (1959 to Hardman Holden). Prepn of ammonium salt: Oxley et al., J. Chem. Soc. 1948, 303.

b -Sitosterol CAS Registry Number: 83-46-5 β-谷甾醇

CAS Name: (3b)-Stigmast-5-en-3-ol
Additional Names: 22:23-dihydrostigmasterol; a-dihydrofucosterol; D5-stigmasten-3b-ol; 24b-ethyl-D5-cholesten-3b-ol; a-phytosterol; cinchol; cupreol; rhamnol; ...
Literature References: Common sterol in plants. Isoln from wheat germ oil, corn oil: Anderson et al., J. Am. Chem. Soc. 48, 2987 (1926); from rye germ oil: Gloyer, Schuette, ibid. 61, 1901 (1939); from cottonseed oil: Wallis, Chakravorty, J. Org. Chem. 2, 335 (1937); from tall oil: Sandqvist, Bengtsson, Ber. 64, 2167 (1931). Also occurs in soy and calabar beans, in rice embryos: Tanaka, J. Biochem. 17, 483 (1933); in cascara, cinchona bark and cinchona wax: Dirscherl, Z. Physiol. Chem. 235, 1 (1935). Prepn from tall oil: G. I. Fujimoto, A. E. Jacobson, J. Org. Chem. 29, 3377 (1964). Identity with 22:23-dihydrostigmasterol: W. Dirscherl, H. Nahm, Ann. 555, 57 (1944). Identity with cinchol: eidem, Ann. 558, 231 (1947). Structure: Bernstein, Wallis, J. Org. Chem. 2, 341 (1937); Bergmann, Low, ibid. 12, 67 (1947); Shoppee, J. Chem. Soc. 1948, 1032. Stereospecific synthesis: W. Sucrow, M. Slopianka, Ber. 108, 3721 (1975). Clinical efficacy in treatment of type II hyperlipoproteinemia: R. S. Lees, A. M. Lees, in Lipoprotein Metabolism, H. Greten, Ed. (Springer-Verlag, New York, 1976) pp 119-124; P. Oster et al., ibid. pp 125-130. Studies on inhibition of cholesterol absorption: S. M. Grundy, H. Y. I. Mok, ibid. pp 112-118; I. Ikeda, M. Sugano, Biochim. Biophys. Acta 732, 651 (1983). Inhibition of induced carcinogenesis: N. D. Nigro et al., J. Natl. Cancer Inst. 69, 103 (1982). Clinical trial in treatment of prostatic adenoma: H.-P. Szutrely, Med. Klin. 77, 520 (1982). Book: Monographs on Atherosclerosis Vol. 10, T. B. Clarkson et al., Eds. entitled "Sitosterol" by O. J. Pollak, D. Kritchevsky (Karger, Basel, 1981) 219 pp.

Zinc Tannate CAS Registry Number: 8011-65-2

Additional Names: Sal barnit
Literature References: Compd of ZnO and tannin in variable proportions. Prepd from an aq tannin soln and zinc hydroxide in excess ammonium hydroxide plus an ammonium salt: DE 479229 (1926 to Lab. Reumella Adolf Boas), C.A. 23, 47781 (1929).

Cimetidine CAS Registry Number: 51481-61-9 西咪替丁

CAS Name: N-Cyano-N'-methyl-N''-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidineTrademarks: Acibilin (Exa); Acinil (GEA); Cimal (AL); Cimetag (Cehasol); Cimetum (Sintyal); Edalene (Rhe-...
Literature References: Competitive histamine H2-receptor antagonist which inhibits gastric acid secretion and reduces pepsin output. Prepn: G. J. Durant et al., BE 804144; eidem, US 3950333 (1974, 1976 both to SKF); P. Kairisalo, E. Honkanen, Arch. Pharm. 316, 688 (1983). Chemistry, pharmacology and toxicology: R. W. Brimblecombe et al., J. Int. Med. Res. 3, 86 (1975); eidem, Br. J. Pharmacol. 53, 435p (1975). Use in combination with other drugs for cancer treatment: R. D. Thornes et al., Lancet 2, 328 (1982); S. Borgström et al., N. Engl. J. Med. 307, 1080 (1982); 308, 591 (1983). Controlled clinical study in treatment of acute upper gastrointestinal tract bleeding: D. Barer et al., ibid. 1571; for prevention of recurrent duodenal ulcer: S. Sontag et al., ibid. 311, 689 (1984). Immunoregulatory effect: J. L. Jorizzo et al., Ann. Intern. Med. 92, 192 (1980); W. B. White, M. Ballow, N. Engl. J. Med. 312, 198 (1985). Review of effect on endocrine secretion: C. Scarpignato, G. Bertaccini, Drugs Exp. Clin. Res. 5(4-5), 129-140 (1979). Symposium on clinical efficacy, cytoprotection and antifibrinolytic effects: Scand. J. Gastroenterol. 21, Suppl. 121, 1-62 (1986).

DPQ CAS Registry Number: 129075-73-6 3,4-二氢-5- [4-(1-哌啶基)丁氧基] -1(2H)-异喹啉酮

CAS Name: 3,4-Dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone
Percent Composition: C 71.49%, H 8.67%, N 9.26%, O 10.58%
Literature References: Competitive inhibitor of poly (ADP-ribose)polymerase (PARP). Prepn: M. J. Suto et al., EP 355720; eidem, US 5177075 (1990, 1993 both to Warner-Lambert). Use and effects as inhibitior: M. J. L. Eliasson et al., Nat. Med. 3, 1089 (1997); K. Takahashi et al., Brain Res. 829, 46 (1999).