其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Coparaffinate CAS Registry Number: 8001-60-3

CAS Name: Isopar
Literature References: A mixture of water-insol isoparaffinic acids partially neutralized with hydroxybenzyldialiphatic amines. The water-insol isoparaffinic acids are obtained by oxidation of petroleum hydrocarbons by the passage of a current of oxygen under pressure at an elevated temp in the presence of a metal catalyst. The water-insol mono- and dicarboxylic acids with from 6 to 16 carbon atoms are separated and purified by fractional distillation. The hydroxybenzyldialiphatic amines are combined directly with the isoparaffinic acids or in suitable solvent. The latter is then removed by distillation: C. E. Earle, US 2262720 (1941).

Radicinin CAS Registry Number: 10088-95-6 根匍柄菌素

CAS Name: [2S-[2a,3b,7(E)]]-2,3-Dihydro-3-hydroxy-2-methyl-7-(1-propenyl)-4H,5H-pyrano[4,3-b]pyran-4,5-dione
Additional Names: stemphylone
Percent Composition: C 61.01%, H 5.12%, O 33.87%
Literature References: A mold metabolite from the plant pathogen Stemphylium radicinum: Clark, Nord, Arch. Biochem. Biophys. 45, 469 (1953); 59, 269 (1955). Structure and identity with stemphylone: Grove, J. Chem. Soc. 1964, 3234. Absolute configuration: M. Nukina, S. Marumo, Tetrahedron Lett. 1977, 3271. Synthesis of dl-form: Kato et al., Chem. Commun. 1969, 95.

Pfeiffer's Substance CAS Registry Number: 8015-18-7 2-羟基缬草酸,盐水合物钠

CAS Name: 5,5-Diethyl-2,4,6(1H,3H,5H)-pyrimidinetrione mixture with 4-(dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one
Additional Names: 4-(Dimethylamino)antipyrine compd with...
Literature References: A molecular compd of aminopyrine and barbital, prepd by repeated crystn of stoichiometric amounts of the components from a minimum of hot water: Pfeiffer, Z. Physiol. Chem. 146, 98 (1925).

Taraxasterol CAS Registry Number: 1059-14-9 蒲公英甾醇

CAS Name: (3b,18a,19a)-Urs-20(30)-en-3-ol
Additional Names: taraxast-20(30)-en-3b-ol; anthesterin; a-lactucerol; taraxasterin
Percent Composition: C 84.44%, H 11.81%, O 3.75%
Literature References: A monohydroxy triterpene. Isoln from Taraxacum officinale, Wiggers, Compositae: Power, Browning, J. Chem. Soc. 101, 2411 (1912). Structure and configuration: Ames et al., ibid. 1954, 1905. Identity with anthesterin: Power, Browning ibid. 105, 1829 (1914); with a-lactucerol: Zellner, Monatsh. Chem. 47, 681 (1926).

Apocodeine CAS Registry Number: 641-36-1 R(-)-阿朴可待因盐酸盐

CAS Name: (6aR)-5,6,6a,7-Tetrahydro-10-methoxy-6-methyl-4H-dibenzo[de,g]quinolin-11-ol
Additional Names: 10-methoxy-6ab-aporphin-11-ol
Percent Composition: C 76.84%, H 6.81%, N 4.98%, O 11.3...
Literature References: A monomethyl ether of apomorphine, q.v. Prepd by heating codeine with oxalic acid: Folkers, J. Am. Chem. Soc. 58, 1814 (1936); by heating codeine with phosphoric acid: Small et al., J. Org. Chem. 5, 344 (1940). Configuration: Corrodi, Hardegger, Helv. Chim. Acta 38, 2038 (1955). Total synthesis and pharmacology: Neumeyer et al., J. Med. Chem. 16, 1223 (1973).

Mimosine CAS Registry Number: 500-44-7 含羞草素

CAS Name: a-Amino-3-hydroxy-4-oxo-1(4H)-pyridinepropanoic acid
Additional Names: 3-hydroxy-4-oxo-1(4H)-pyridinealanine; b-[N-(3-hydroxy-4-pyridone)]-a-aminopropionic acid; leucenol; leucenine; ...
Literature References: A naturally occurring amino acid found in large quantities in the seeds and foliage of the legume genera Mimosa and Leucena. Isoln from Leucena glauca (Willd.) Benth., Leguminosae: Renz, Z. Physiol. Chem. 244, 153 (1936); Mascré, Compt. Rend. 204, 890 (1937); improved large-scale isoln: N. K. Hart et al., Heterocycles 7, 265 (1977). Structure: Adams, Jones, J. Am. Chem. Soc. 69, 1803 (1947). Synthesis: Adams, Johnson, ibid. 71, 705 (1949). Identity of mimosine and leucenol: Kleipool, Wibaut, Rec. Trav. Chim. 69, 37 (1950); Wibaut, Schuhmacher, ibid. 71, 1017 (1952). Crystal structure: A. Mostad et al., Acta Chem. Scand. 27, 164 (1973). Shown to cause inhibition of hair growth and loss of hair in mice: Crounse et al., Nature 194, 694 (1962). Explanation of the toxicity in animals: J. F. Thompson et al., Annu. Rev. Biochem. 38, 137 (1969).

Palmidrol CAS Registry Number: 544-31-0 十六酰胺乙醇

CAS Name: N-(2-Hydroxyethyl)hexadecanamide
Additional Names: N-(2-hydroxyethyl)palmitamide
Percent Composition: C 72.19%, H 12.45%, N 4.68%, O 10.68%
Literature References: A naturally occurring anti-inflammatory agent. Isolated from soybean lecithin, egg yolk, and peanut meal: Kuehl et al., J. Am. Chem. Soc. 79, 5577 (1957). Synthesis by refluxing ethanolamine with palmitic acid: Roe et al., ibid. 74, 3442 (1952).

Biocytin CAS Registry Number: 576-19-2 生物胞素

CAS Name: N6-[5-(Hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl]-L-lysine
Additional Names: e-N-biotinyl-L-lysine; biotin complex of yeast
Percent Composition: C 51.59%, H 7.58%,...
Literature References: A naturally occurring complex of biotin. Contains 65.6% biotin. Isoln: Wright et al., J. Am. Chem. Soc. 72, 1048 (1950); 74, 1996 (1952). Structure: Peck et al., ibid. 72, 1048 (1950); 74, 1999 (1952). Synthesis: Wolf et al., ibid. 74, 2002 (1952); Weijlard et al., ibid. 76, 2505 (1954); Wolf, Folkers, US 2710298 (1955 to Merck Co.). Purification: McCormick, Föry, Methods Enzymol. 18 (pt A), 413 (1970). Review: A. F. Wagner, K. Folkers, Vitamins and Coenzymes (Wiley, New York, 1964) pp 138-159.

Metanephrine CAS Registry Number: 5001-33-2 间甲肾上腺素

CAS Name: 4-Hydroxy-3-methoxy-a-(methylaminomethyl)benzenemethanol
Additional Names: a-(methylaminomethyl)vanillyl alcohol; 3-O-methylepinephrine; 3-O-methyladrenaline; 1-(4-hydroxy-3-methoxyph...
Literature References: A naturally occurring derivative of epinephrine, found in the urine and in certain tissues. Various methods of prepn: Külz, Hornung, DE 682394 (1939); Chem. Zentralbl. 1940, I, 1078, C.A. 36, 3011 (1942); Axelrod et al., J. Biol. Chem. 233, 697 (1958); Heacock, Hutzinger, Chem. Ind. (London) 1961, 595.

Normetanephrine CAS Registry Number: 97-31-4 盐酸肾上腺素-D3

CAS Name: a-(Aminomethyl)-4-hydroxy-3-methoxybenzenemethanol
Additional Names: a-(aminomethyl)vanillyl alcohol; 4-hydroxy-3-methoxy-a-(aminomethyl)benzyl alcohol; 1-(4-hydroxy-3-methoxyphenyl)-...
Literature References: A naturally occurring derivative of epinephrine, found together with metanephrine in urine and in certain tissues. Prepn: Fodor et al., Acta Chim. Acad. Sci. Hung. 1, 395 (1951), C.A. 49, 897 (1955); Axelrod et al., J. Biol. Chem. 233, 697 (1958); Heacock, Hutzinger, Chem. Ind. (London) 1961, 595.