其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Etozolin CAS Registry Number: 73-09-6 依托唑啉

CAS Name: [3-Methyl-4-oxo-5-(1-piperidinyl)-2-thiazolidinylidene]acetic acid ethyl ester
Additional Names: 2-carbethoxymethylene-3-methyl-5-piperidino-4-thiazolidone; 3-methyl-4-oxo-5-piperidin...
Literature References: A member of a new class of heterocyclic compounds, the 2-methylenethiazolidones; a diuretic with choleretic properties. Prepn: Satzinger, Ann. 665, 150 (1963); US 3072653 (1963 to Warner-Lambert). Pharmacology: O. Heidenreich et al., Arzneim.-Forsch. 14, 1242 (1964). Series of articles on activity, metabolism and toxicology: G. Satzinger et al., ibid. 27, 1742-1817 (1977); M. Herrmann et al., ibid. 1745.

Protostephanine CAS Registry Number: 549-28-0 2,3,10,12-四甲氧基-7-甲基-6,7,8,9-四氢-5H-二苯并[D,F]氮杂环壬烷

CAS Name: 6,7,8,9-Tetrahydro-2,3,10,12-tetramethoxy-7-methyl-5H-dibenz[d,f]azonine
Percent Composition: C 70.56%, H 7.61%, N 3.92%, O 17.90%
Literature References: A member of the hasubanan alkaloids. First alkaloid known to possess the unique dibenz[d,f]azonine structure. Isoln from Stephania japonica, Miers, Menispermaceae: H. Kondo, T. Sanada, J. Pharm. Soc. Jpn. 541, 177 (1927), C.A. 21, 27004 (1927); H. Kondo, T. Watanabe, ibid. 58, 268 (1938), C.A. 32, 54035 (1938). Structure: K. Takeda, Bull. Agric. Chem. Soc. Jpn. 20, 165 (1956). Synthesis: idem, C.A. 60, 5570f (1964); B. Pecherer, A. Brossi, J. Org. Chem. 32, 1053 (1967); A. R. Battersby et al., J. Chem. Soc. Perkin Trans. 1 1981, 2002. Biosynthesis: eidem, ibid. 2010, 2016, 2030.

Metaphanine CAS Registry Number: 1805-86-3 (8beta,10beta)-8-羟基-3,4-二甲氧基-17-甲基-8,10-环氧莲花烷-7-酮

CAS Name: (8b,10b)-8,10-Epoxy-8-hydroxy-3,4-dimethoxy-17-methylhasubanan-7-one
Percent Composition: C 66.07%, H 6.71%, N 4.06%, O 23.16%
Literature References: A member of the hasubanan alkaloids; also possesses an intramolecular hemiketal ring. Isolated from stems of Stephania japonica Miers, Menispermaceae from which the alkaloids stephanine and protostephanine, q.v. are also obtained: Kondo, Sanada, J. Pharm. Soc. Jpn. 514, 5 (1924); Yakugaku Zasshi 44, 5, 1034 (1924); 48, 177, 930 (1927); Kondo, Watanabe, ibid. 58, 268 (1938). Structure and stereochemistry: Tomita et al., Tetrahedron Lett. 1964, 3605; Chem. Pharm. Bull. 13, 695 (1965). Synthesis of dl-form: Ibuka et al., Tetrahedron Lett. 1972, 1393; eidem, Chem. Pharm. Bull. 22, 907 (1974).

Verticine CAS Registry Number: 23496-41-5 贝母甲素

CAS Name: (3b,5a,6a)-Cevane-3,6,20-triol
Additional Names: peimine
Percent Composition: C 75.13%, H 10.51%, N 3.24%, O 11.12%
Literature References: A member of the hexacyclic Ceveratrum group of alkaloids. Isoln from Fritillaria verticillata Willd. var. Thunbergii Baker, Liliaceae: Fukuda: Sci. Rep. Res. Inst. Tohoku Univ. Ser. A 18, 323 (1929); Morimoto, Kimata, Chem. Pharm. Bull. 8, 302 (1960). Also isolated from F. roylei Hook: Chou, Chen, Chin. J. Physiol. 6, 265 (1932), C.A. 26, 5703 (1932). Structure: Ito et al., ibid. 11, 1337 (1963). Abs config: S. Ito et al., Tetrahedron Lett. 1968, 5373. Total synthesis: J. P. Kutney et al., J. Am. Chem. Soc. 99, 964 (1977).

Pregnanediol CAS Registry Number: 80-92-2 5β-孕烷-3α,20α-二醇

CAS Name: (3a,5b,20S)-Pregnane-3,20-diol
Percent Composition: C 78.69%, H 11.32%, O 9.98%
Literature References: A metabolite of progesterone, present in large amounts in pregnancy urine. Isoln from pregnancy urine of women: Marrian, Biochem. J. 23, 1090 (1929), Butenandt, Ber. 63, 659 (1930); of cows, mares, and chimpanzees: Fish et al., J. Biol. Chem. 143, 716 (1942). Prepn by reduction of pregn-16-ene-3,20-dione: Marker et al., US 2352852 (1944 to Parke, Davis). Conversion to progesterone: Butenandt, Schmidt, Ber. 67, 1893, 1901 (1934). Conversion to 3a-hydroxypregnan-20-one: Marker, US 2223377 (1940 to Parke, Davis). Prepn of the 3-acetate: Hirschmann, J. Biol. Chem. 140, 797 (1941); Ralls et al., ibid. 210, 709 (1954). Prepn of the 20-acetate: Hirschmann, loc. cit. Prepn of the diacetate: Johnson et al., J. Chem. Soc. 1954, 1302. Crystal structure: Haner, Norton, Acta Crystallogr. 16, 707 (1963). Review of metabolism, bioactivity and assay during pregnancy: P. J. Keller, Contrib. Gynecol. Obstet. 2, 75-91 (1976).

Toxopyrimidine CAS Registry Number: 73-67-6 4-氨基-2-甲基-5-嘧啶甲醇

CAS Name: 4-Amino-2-methyl-5-pyrimidinemethanol
Additional Names: 6-amino-5-hydroxymethyl-2-methylpyrimidine; 4-amino-5-hydroxymethyl-2-methylpyrimidine; pyramin; pyramine
Percent Compositio...
Literature References: A metabolite of thiamine. Prepd from 4-amino-5-aminomethyl-2-methylpyrimidine dihydrochloride or ethyl 4-amino-2-methyl-5-pyrimidinecarboxylate: Dornow, Petsch, Ber. 86, 1404 (1953); DiBella, Hennessy, J. Org. Chem. 26, 2017 (1961).

Sarmentose CAS Registry Number: 13484-14-5

CAS Name: 2,6-Dideoxy-3-O-methyl-xylo-hexose
Percent Composition: C 51.84%, H 8.70%, O 39.46%
Literature References: A methyl ether of a 2-desoxyhexomethylose, isomeric with cymarose. Obtained on hydrolysis of sarmentocymarin, a glycoside isolated from seeds of Strophanthus sarmentosus DC., Apocynaceae by the enzymic method: Jacobs, Heidelberger, J. Biol. Chem. 81, 765 (1929); Jacobs, Bigelow, ibid. 96, 355 (1932). Synthesis: H. Hauenstein, T. Reichstein, Helv. Chim. Acta 33, 446 (1950).

Cryolite CAS Registry Number: 15096-52-3 铝氟酸钠

Additional Names: Kryolith; ice spar; sodium aluminum fluoride
Percent Composition: Al 12.85%, F 54.30%, Na 32.85%
Literature References: A mineral named for its resemblance to ice; large deposits existed in Greenland and in the Urals. Synthetic cryolite is usually made from NaAlO2, NaHCO3 and NaF. See the review by Vogel, Chem. Ztg. 75, 603 (1951).

Butylated Hydroxyanisole CAS Registry Number: 25013-16-5 丁基羟基茴香醚

CAS Name: (1,1-Dimethylethyl)-4-methoxyphenol
Additional Names: 2(3)-tert-butyl-4-hydroxyanisole; BHA
Trademarks: Antrancine 12 (Jandekker); Embanox; Nipantiox 1-F (Nipa); Sustane 1-F (UOP);...
Literature References: A mixture of 2-tert-butyl-4-methoxyphenol (also called 3-tert-butyl-4-hydroxyanisole) and 3-tert-butyl-4-methoxyphenol (also called 2-tert-butyl-4-hydroxyanisole). Prepn from p-methoxyphenol and isobutene: R. H. Rosenwald, US 2459540; US 2470902 (both 1949 to Universal Oil Products). Toxicity study: A. J. Lehman et al., Adv. Food Res. 3, 197 (1951). Review of carcinogenic risk: IARC Monographs 40, 123-159 (1986); antimicrobial activity: M. Riccach, J. Food Saf. 6, 141-170 (1984); of physicochemical properties, antioxidant activity and toxicology: H. Verhagen et al., Chem. Biol. Interact. 80, 109-134 (1991); of safety assessment as food additive: G. M. Williams et al., Food Chem. Toxicol. 37, 1027-1038 (1999).

Spirit of Ether Compound CAS Registry Number: 8013-44-3

Additional Names: Hoffmann's anodyne
Literature References: A mixture of 325 ml ether U.S.P., 25 ml ethereal oil and sufficient alcohol (~665 ml) to make 1000 ml. Absolute alc by vol, ~64%.