Biocytin CAS Registry Number: 576-19-2 生物胞素
CAS Name: N6-[5-(Hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl]-L-lysine
Additional Names: e-N-biotinyl-L-lysine; biotin complex of yeast
Percent Composition: C 51.59%, H 7.58%, N 15.04%, O 17.18%, S 8.61%
📌 参考资料/链接：
Literature References: A naturally occurring complex of biotin. Contains 65.6% biotin. Isoln: Wright et al., J. Am. Chem. Soc. 72, 1048 (1950); 74, 1996 (1952). Structure: Peck et al., ibid. 72, 1048 (1950); 74, 1999 (1952). Synthesis: Wolf et al., ibid. 74, 2002 (1952); Weijlard et al., ibid. 76, 2505 (1954); Wolf, Folkers, US 2710298 (1955 to Merck Co.). Purification: McCormick, Föry, Methods Enzymol. 18 (pt A), 413 (1970). Review: A. F. Wagner, K. Folkers, Vitamins and Coenzymes (Wiley, New York, 1964) pp 138-159.
📄 详细内容
Properties: Crystals, mp 241-243°. Upon rapid crystn from dil methanol or dil acetone, mp 228-230° (dec); upon slow crystn sinters at 227°. mp 245-252° (dec, microblock). Crystals from water, mp 228.5°. [a]D25 +53° (c = 1.05 in 0.1N NaOH). Infrared absorption spectrum: J. Am. Chem. Soc.
74, 2001 (1952). Freely sol in water, glacial acetic acid. Less sol in alc. Practically insol in acetone and most other organic solvents. When subjected to strong acid hydrolysis (at least 3N at 120° for one hour) biocytin yields biotin and L-lysine. Forms a crystalline hydrochloride. Biocytin is characterized microbiologically by its availability as a source of biotin to Lactobacillus casei, L. delbrückii LD 5, L. acidophilus, Streptococcus fecalis R, Neurospora crassa, and Saccharomyces carlsbergensis and by its unavailability as a source of biotin to Lactobacillus arabinosus, L. pentosus, and Leuconostoc mesenteroides P-60.
Melting point: mp 241-243°; mp 228-230° (dec); mp 245-252° (dec, microblock); mp 228.5°
Optical Rotation: [a]D25 +53° (c = 1.05 in 0.1N NaOH)
产品链接: 576-19-2››