CAS: 576-19-2; H-Lys(Biotinyl)-Oh

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CAS号35013-72-0 (+)生物素-N-琥珀酰亚胺基酯 | CAS号857358-40-8 N2-formyl-N6-[5... | CAS号608-16-2 (+)-生物素甲基酯 | CAS号56-87-1 L-赖氨酸 | CAS号62062-43-5 N-叔丁氧羰基-N'-生物素-L-赖氨酸 | CAS号1155-64-2 Nε-苄氧羰基-L-赖氨酸 | CAS号13734-28-6 B°C-L-赖氨酸 | CAS号33755-53-2 (+)-生物素4-硝基苯酯 | CAS号58-85-5 D-生物素

📜(+)生物素-N-琥珀酰亚胺基酯置于1,8-二氮杂双环[5.4.0]十一碳-7-烯,Sodium Hydroxide体系中,用 1,4-二氧六环,水,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 1.0H,反应生成 生物胞素
参考文献:Identification Of Annexin A2 As A Target Protein For Plant Alkaloid Matrine
标题:Identification Of Annexin A2 As A Target Protein For Plant Alkaloid Matrine
摘要:甲硷的细胞靶标已经确定.
DOI:10.1039/c7Cc02227A

专利信息

专利号:US-6451543-B1
优先权日:1998-08-31
标题:Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides
发明人：KOCHENDOERFER GERD G; HUNTER CHRISTIE L; KENT STEPHEN B H; BOTTI PAOLO
权利人:GRYPHON SCIENCES
摘要:The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefolded membrane polypeptide embedded within a lipid matrix via stepwise chemoselective chemical ligation of unprotected peptide segments, where at least one peptide segment is embedded in a lipid matrix. Any chemoselective reaction chemistry amenable for ligation of unprotected peptide segments can be employed. Suitable lipid matrices include liposomes, micelles, cell membrane patches and optically isotropic cubic lipidic phase matrices. Prefolded synthetic and semi-synthetic membrane polypeptides synthesized according to the methods and compositions of the invention also permit site-specific incorporation of one or more detectable moieties, such as a chromophore, which can be conveniently introduced during synthesis. The methods and compositions of the invention have multiple uses. For example, they can be used to assay ligand binding to membrane polypeptides and domains comprising a receptor, and thus are extremely useful for structure/function studies, drug screening/selection/design, and diagnostics and the like, including high-throughput applications. The methods and compositions of the invention are particularly suited for FRET analyses of previously inaccessible membrane polypeptides.

专利号:WO-0012554-A1
优先权日:1998-08-28
标题:Method for marked chemokine synthesis, marked chemokine and analysis kit
发明人：VITA CLAUDIO; VIZZAVONA JEAN; GLUCKMAN JEAN CLAUDE; BENJOUARD ABDELAZIZ
权利人:COMMISSARIAT ENERGIE ATOMIQUE; UNIV PARIS CURIE; VITA CLAUDIO; VIZZAVONA JEAN; GLUCKMAN JEAN CLAUDE; BENJOUARD ABDELAZIZ
摘要:The invention concerns a method for the homogeneous synthesis of a marked chemokine in a specific position. The invention also concerns a chemokine obtained by said method, a composition and a kit comprising said chemokine. The invention is characterised in the method for the synthesis of the marked chemokine comprises a step which consists in a solid phase chemical synthesis of the chemokine or a modified sequence thereof.

专利号:US-2010247433-A1
优先权日:2005-10-14
标题:Use of non-canonical amino acids as metabolic markers for rapidly-dividing cells
发明人：TIRRELL DAVID; DIETERICH DANIELA C; LINK AARON J; SCHUMAN ERIN
权利人:CALIFORNIA INST OF TECHN
摘要:The invention provides methods, reagents and systems to preferentially mark fast-proliferating cells/tissues (such as cancer), by incorporating non-natural amino acids into proteins, preferably in vivo, using the endogenous protein synthesis machinery of an organism. The incorporated non-natural amino acids contain reactive groups for further chemical reagents, which may serve as a “handleâ€? to for a number of uses, such as imaging of cancer cells, targeting drugs to preferentially kill cancer cells, and proteomic analysis in the context of large scale or high throughput screening for candidate drug leads that affects the proliferation of a target cell, etc.

专利号:US-7482425-B2
优先权日:1999-08-26
标题:Compositions for lipid matrix-assisted chemical ligation
发明人：KOCHENDOERFER GERD G; HUNTER CHRISTIE L; KENT STEPHEN B H; BOTTI PAOLO
权利人:AMYLIN PHARMACEUTICALS INC
摘要:The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefolded membrane polypeptide embedded within a lipid matrix via stepwise chemoselective chemical ligation of unprotected peptide segments, where at least one peptide segment is embedded in a lipid matrix. Any chemoselective reaction chemistry amenable for ligation of unprotected peptide segments can be employed. Suitable lipid matrices include liposomes, micelles, cell membrane patches and optically isotropic cubic lipidic phase matrices. Prefolded synthetic and semi-synthetic membrane polypeptides synthesized according to the methods and compositions of the invention also permit site-specific incorporation of one or more detectable moieties, such as a chromophore, which can be conveniently introduced during synthesis. The methods and compositions of the invention have multiple uses. For example, they can be used to assay ligand binding to membrane polypeptides and domains comprising a receptor, and thus are extremely useful for structure/function studies, drug screening/selection/design, and diagnostics and the like, including high-throughput applications. The methods and compositions of the invention are particularly suited for FRET analyses of previously inaccessible membrane polypeptides.

专利号:US-5980861-A
优先权日:1996-03-12
标题 :Chelator compositions and methods of synthesis thereof
发明人：HNATOWICH DONALD J; RUSCKOWSKI MARY; MARDIROSSIAN GEORGE; WINNARD JR PAUL; CHANG FENGCHUN
权利人:UNIV MASSACHUSETTS
摘要:Compositions of radiolabeled nucleic acids and methods for synthesis and use thereof are disclosed.

专利号:US-2008051323-A1
优先权日:2004-08-21
标 题 :Chloroquine drug compositions and methods for their synthesis
发明人：KOSAK KENNETH M
权利人:KOSAK KENNETH M
摘要:This invention discloses compositions of chloroquine-coupled active agents, including methods for their preparation. The prior art has shown that chloroquines given as free drug in high enough concentration, enhances the release of various agents from cellular endosomes into the cytoplasm. The purpose of these compositions is to provide a controlled amount of chloroquine at the same site where the active agent is delivered, thereby reducing the overall dosage needed. n The compositions comprise a chloroquine substance coupled to an active agent directly or through a variety of pharmaceutical carrier substances. The carrier substances include polysaccharides, synthetic polymers, proteins, micelles and other substances for carrying and releasing the chloroquine compositions in the body for therapeutic effect. The compositions can also include a biocleavable linkage for carrying and releasing active agents for therapeutic or other medical uses. The invention also discloses carrier compositions that are coupled to targeting molecules for targeting the delivery of chloroquine substances and active agents to their site of action.