其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Tiron CAS Registry Number: 149-45-1 邻苯二酚-3,5-二磺酸钠

CAS Name: 4,5-Dihydroxy-1,3-benzenedisulfonic acid disodium salt
Additional Names: 1,2-dihydroxybenzene-3,5-disulfonic acid disodium salt; disodium-1,2-dihydroxybenzene-3,5-disulfonate; sodium ...
Literature References: Chelating agent. Prepn: Fukayama et al., JP 52 4327 (1952 to Sanwa Pure Chem.), C.A. 48, 5215c (1954). Use in HPLC determn of iron, titanium, osmium and aluminum: E. Wang, A. Liu, Microchem. J. 43, 191 (1991); in spectrophotometric determn of titanium: S. Honshi et al., Anal. Sci. 13, 863 (1997).

EGTA CAS Registry Number: 67-42-5 3,6-二氧杂-1,8-辛二胺四乙酸(EGTA)

CAS Name: 3,12-Bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecanedioic acid
Additional Names: [ethylenebis(oxyethylenenitrilo)]tetraacetic acid; ethylene glycol bis(b-aminoethylether)-N,N,N',N'...
Literature References: Chelating agent. Prepn: H. Schläpfer, J. Bindler, US 2709178 (1955 to Geigy). Toxicology: J. E. Wynn et al., Toxicol. Appl. Pharmacol. 16, 807 (1970). Thermal properties: M. F. G. Esteban et al., Thermochim. Acta 62, 267 (1983). Cathodic-stripping determn: M. Ciszkowska, Z. Stojek, Talanta 33, 817 (1986). Use in calcium measurements: J. D. Johnson et al., Am. J. Physiol. 272, C1437 (1997); in heavy metal remobilization from river sediment: K.-C. Yu et al., Toxicol. Environ. Chem. 58, 85 (1997). Review of regulation of Ca+2 concentration in biological systems: S. Robertson, J. D. Potter, Methods Pharmacol. 5, 63-75 (1984).

w -Chloroacetophenone CAS Registry Number: 532-27-4 2-氯苯乙酮

CAS Name: 2-Chloro-1-phenylethanone
Additional Names: 2-chloroacetophenone; a-chloroacetophenone; phenacyl chloride; Chemical Mace; CN
Percent Composition: C 62.16%, H 4.56%, Cl 22.93%, O 10...
Literature References: Chemical warfare agent with lacrimatory properties. Prepn: R. Scholl, H. Korten, Ber. 34, 1902 (1901); H. Rheinboldt, M. Perrier, J. Am. Chem. Soc. 69, 3148 (1947); Schaefer, Sonnenberg, J. Org. Chem. 28, 1128 (1963). Purification: Lofton, US 2414418 (1947 to Pennsylvania Coal Prod.). Melting point determination and review of prepn: Macy, J. Chem. Educ. 24, 222 (1947). Comparative toxicity with o-chlorobenzylidenemalononitrile, q. v.: B. Ballantyne, D. W. Swanston, Arch. Toxicol. 40, 75 (1978).

Clinprost CAS Registry Number: 88931-51-5 克林前列素

CAS Name: (3aS,5R,6R,6aS)-1,3a,4,5,6,6a-Hexahydro-5-hydroxy-6-(3-hydroxy-1-octenyl)-2-pentalenepentanoic acid methyl ester
Additional Names: isocarbacyclin methyl esterPercent Composition: C 72...
Literature References: Chemically stable prostacyclin (PGI2) analog. Prepn: S. Kurozumi, S. Ikegami, WO 8402902; eidem, US 4736058 (1984, 1988 both to Teijin); M. Shibasaki et al., Tetrahedron Lett. 24, 3493 (1983). Stereosynthesis: H. Park et al., Bull. Korean Chem. Soc. 14, 86 (1993). Series of articles on pharmacology: Arzneim.-Forsch. 45, 967-993 (1995). Clinical trial as lipid emulsion in peripheral vascular disorders: K. Esato, Adv. Prostaglandin Thromboxane Leukotriene Res. 23, 405 (1995).

Phenethyl Isothiocyanate CAS Registry Number: 2257-09-2 异硫氰酸-2-苯乙酯

CAS Name: (2-Isothiocyanatoethyl)benzene
Additional Names: 2-phenylethyl isothiocyanate; PEITC
Percent Composition: C 66.22%, H 5.56%, N 8.58%, S 19.64%
Literature References: Chemopreventive agent found in cruciferous vegetables; produced by hydrolysis of gluconasturtiin. Prepn: J. v. Braun, H. Deutsch, Ber. 45, 2188 (1912); E. Schmidt et al., Ann. 612, 11 (1958); and isoln from turnips: E. P. Lichtenstein et al., J. Agric. Food Chem. 10, 30 (1962). Isoln from cabbage and watercress seeds: N. Kaoulla et al., Phytochemistry 19, 1053 (1980). LC/MS determn in plasma and urine: Y. Ji, M. E. Morris, Anal. Biochem. 323, 39 (2003). Chemopreventive studies in animal models: G. D. Stoner, Curr. Top. Plant Physiol. 15, 78 (1995); A. Nishikawa et al., Curr. Cancer Drug Targets 4, 373 (2004). Mechanistic studies of anticancer activity and induction of apoptosis: Y.-R. Chen et al., J. Biol. Chem. 277, 39334 (2002); R. Hu et al., Carcinogenesis 24, 1361 (2003); D. Xiao et al., Clin. Cancer Res. 11, 2670 (2005).

Biricodar CAS Registry Number: 159997-94-1 1,7-二(吡啶-3-基)庚烷-4-基(2S)-1-[2-氧代-2-(3,4,5-三甲氧基苯基)乙酰基]哌啶-2-羧酸酯

CAS Name: (2S)-1-[Oxo(3,4,5-trimethoxyphenyl)acetyl]-2-piperidinecarboxylic acid 4-(3-pyridinyl)-1-[3-(3-pyridinyl)propyl]butyl ester
Percent Composition: C 67.64%, H 6.85%, N 6.96%, O 18.55%
Literature References: Chemosensitizer that restores sensitivity to cytotoxic agents in multidrug resistant (MDR) cells. Prepn: D. M. Armistead et al., WO 9407858; eidem, US 5620971 (1994, 1997 both to Vertex). Effect on MDR mediated by P-glycoprotein: U. A. Germann et al., Anti-Cancer Drugs 8, 125 (1997); by multidrug resistance-associated protein (MRP): eidem, ibid. 141. Clinical pharmacology, pharmacokinetics: E. K. Rowinsky et al., J. Clin. Oncol. 16, 2964 (1998).

Podocarpic Acid CAS Registry Number: 5947-49-9 罗汉松酸

CAS Name: [1S-(1a,4aa,10ab)]-1,2,3,4,4a,9,10,10a-Octahydro-6-hydroxy-1,4a-dimethyl-1-phenanthrenecarboxylic acid
Additional Names: 12-hydroxypodocarpa-8,11,13-trien-16-oic acid
Percent Compo...
Literature References: Chief acidic constituent of the resin of the Javanese Podocarpus cupressina (L'Hérit.) Pers., Coniferae, esp. in var. imbricata. Also in New Zealand kahikatea resin (from Podocarpus dacrydioides) and in rimu resin (Dacrydium cupressinum). A related component, nimbiol, q.v., occurs in the nim tree, Azadirachta indica Juss. (Melia azadirachta L.), Meliaceae. Isoln from Podocarpus cupressina: A. C. Oudemans, Ber. 6, 1122 (1873); from Dacrydium cupressinum: I. R. Sherwood, W. F. Short, J. Chem. Soc. 1938, 1008. Structure: Campbell, Todd, J. Am. Chem. Soc. 64, 928 (1942). Conversion to nimbiol as proof of structure: Bible, Tetrahedron 11, 22 (1960). Synthesis from desoxypodocarpic acid: Wenkert, Jackson, J. Am. Chem. Soc. 80, 217 (1958). Total synthesis of dl-form: Meyer, Maheshwari, Tetrahedron Lett. 1964, 2175; P. R. Kanjilal et al., Synth. Commun. 11, 795 (1981). Synthesis: Pelletier et al., Tetrahedron Lett. 1971, 4179.

a MNP CAS Registry Number: 63628-25-1 2-甲氧基-2-(1-萘基)丙酸

CAS Name: a-Methoxy-a-methyl-1-naphthaleneacetic acid
Additional Names: 2-methoxy-2-(1-naphthyl)propanoic acid
Percent Composition: C 73.03%, H 6.13%, O 20.85%
Literature References: Chiral derivatization reagent. Prepn and application to amino acids: J. Goto et al., Chem. Pharm. Bull. 25, 847 (1977); eidem, J. Chromatogr. 152, 413 (1978). Resolution of enantiomers and abs config: N. Harada et al., Tetrahedron: Asymmetry 11, 1249 (2000). Use in alcohol resolution: A. Ichikawa, Chirality 11, 70 (1999).

Mosher's Reagent CAS Registry Number: 81655-41-6 (±)-α-甲氧基-α-(三氟甲基)苯乙酸

CAS Name: a-Methoxy-a-(trifluoromethyl)benzeneacetic acid
Additional Names: (±)-Mosher's acid; MTPA; 2-methoxy-2-(trifluoromethyl)phenylacetic acid
Percent Composition: C 51.29%, H 3.87...
Literature References: Chiral derivatizing reagent. Prepn: D. L. Dull, H. S. Mosher, J. Am. Chem. Soc. 89, 4230 (1967); J. A. Dale et al., J. Org. Chem. 34, 2543 (1969). Microscale prepn: D. E. Ward, C. K. Rhee, Tetrahedron Lett. 32, 7165 (1991). Absolute configuration: S. S. Oh et al., J. Org. Chem. 54, 4499 (1989); of the acid chloride: B. S. Joshi, S. W. Pelletier, Heterocycles 51, 183 (1999). Enantiomeric purity of commerical samples: W. A. König et al., Tetrahedron Lett. 31, 6867 (1990). Use in determn of abs config: T. R. Hoye, M. K. Renner, J. Org. Chem. 61, 2056 (1996); A. Ichikawa, Enantiomer 3, 255 (1998); L. F. Tietze et al., Eur. J. Org. Chem. 2000, 2247.

(S,S)-Chiraphos CAS Registry Number: 64896-28-2 (2S,3S)-(-)-双(二苯基膦)丁烷

CAS Name: [(1S,2S)-1,2-Dimethyl-1,2-ethanediyl]bis[diphenylphosphine]
Additional Names: (2S,3S)-(-)-bis(diphenylphosphino)butane
Percent Composition: C 78.86%, H 6.62%, P 14.53%
Literature References: Chiral, bidentate phosphine ligand in asymmetric catalysis. Prepn: M. D. Fryzuk, B. Bosnich, J. Am. Chem. Soc. 99, 6262 (1977); J. F. G. Jansen, B. L. Feringa, Tetrahedron: Asymmetry 1, 719 (1990); S. H. Bergens et al., Inorg. Synth. 31, 131 (1997). 1H and 31P NMR of platinum complexes: N. C. Payne, D. W. Stephan, J. Organomet. Chem. 221, 203 (1981). Synthetic applications: C. Moinet, J.-C. Fiaud, Tetrahedron Lett. 36, 2051 (1995); H. Frauenrath et al., Tetrahedron: Asymmetry 9, 1103 (1998); K. Akiyama et al., Adv. Synth. Catal. 347, 1569 (2005).