网站主页>>>项目整合精选>>>项目整合精选>>>Mosher's Reagent CAS Registry Number: 81655-41-6 (±)-α-甲氧基-α-(三氟甲基)苯乙酸

Mosher's Reagent CAS Registry Number: 81655-41-6 (±)-α-甲氧基-α-(三氟甲基)苯乙酸

CAS Name: a-Methoxy-a-(trifluoromethyl)benzeneacetic acid
Additional Names: (±)-Mosher's acid; MTPA; 2-methoxy-2-(trifluoromethyl)phenylacetic acid
Percent Composition: C 51.29%, H 3.87%, F 24.34%, O 20.50%

📌 参考资料/链接：
Literature References: Chiral derivatizing reagent. Prepn: D. L. Dull, H. S. Mosher, J. Am. Chem. Soc. 89, 4230 (1967); J. A. Dale et al., J. Org. Chem. 34, 2543 (1969). Microscale prepn: D. E. Ward, C. K. Rhee, Tetrahedron Lett. 32, 7165 (1991). Absolute configuration: S. S. Oh et al., J. Org. Chem. 54, 4499 (1989); of the acid chloride: B. S. Joshi, S. W. Pelletier, Heterocycles 51, 183 (1999). Enantiomeric purity of commerical samples: W. A. König et al., Tetrahedron Lett. 31, 6867 (1990). Use in determn of abs config: T. R. Hoye, M. K. Renner, J. Org. Chem. 61, 2056 (1996); A. Ichikawa, Enantiomer 3, 255 (1998); L. F. Tietze et al., Eur. J. Org. Chem. 2000, 2247.

📄 详细内容

Derivative Type: (R)-(+)-Form
CAS Registry Number: 20445-31-2
Properties: bp1.5 mm 116-118°. [a]D25 +68.5 ± 1.3° (c = 1.49 in CH3OH).
Boiling point: bp1.5 mm 116-118°
Optical Rotation: [a]D25 +68.5 ± 1.3° (c = 1.49 in CH3OH)
Derivative Type: (S)-(-)-Form
CAS Registry Number: 17257-71-5
Properties: bp1.5 mm 115-117°. [a]D24 -71.8± 0.6° (c = 3.28 in CH3OH).
Boiling point: bp1.5 mm 115-117°
Optical Rotation: [a]D24 -71.8± 0.6° (c = 3.28 in CH3OH)
Derivative Type: (R)-(-)-Acid chloride
CAS Registry Number: 39637-99-5
Additional Names: (R)-MTPA-chloride
Properties: bp1 mm 54-56°. [a]D25 -10.0± 0.1° (neat, l = 1).
Boiling point: bp1 mm 54-56°
Optical Rotation: [a]D25 -10.0± 0.1° (neat, l = 1)
Derivative Type: (S)-(+)-Acid chloride
CAS Registry Number: 20445-33-4
Properties: bp1 mm 54-56°. [a]D24 +129.0± 0.2° (c = 5.17 in CCl4).
Boiling point: bp1 mm 54-56°
Optical Rotation: [a]D24 +129.0± 0.2° (c = 5.17 in CCl4)
Use: Resolution of enantiomers primarily of alcohols and amines.
产品链接: 81655-41-6››

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