CAS: 81655-41-6; 3,3,3-Trifluoro-2-Methoxy-2-Phenylpropanoic Acid

该化合物是一个化学化合物,其特点是其独特的功能组和结构,其特征是三氟甲基组,大大增强了其脂性和生物活动;甲氧基组的存在有助于其在有机溶剂中的再活性和溶解性;该化合物通常由于箱式酸功能组而具有酸性,允许其参与各种化学反应,包括洗涤和恐吓;其分子结构表明药物中的潜在应用,特别是在针对特定生物途径开发药物方面.此外,已知三氟甲基组会影响该化合物的代谢稳定性和药用动力学.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

methanol α-(Chlordifluormethyl)-α-(trifluormethyl)-benzylalkohol Methyl (S)-2-methoxy-2-phenyl-3,3,3-trifluoropropionate Trimethyl-(2,2,2-trichloro-1-phenyl-1-trifluoromethyl-ethoxy)-silane (2S)-2,3-dimethylbutyl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropionate (2S)-2-methylpentyl (S)-3,3,3-trifluoro-2-methoxy-2-phenylpropionate 3-O-MTPA-2-butanone (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (7S,8S)-8-hydroxy-7,8,9,10-tetrahydro-benzo[def]chrysen-7-yl ester

合成工艺路线路线简述

  • 80866-87-1 = 81655-41-6
    反应条件:1.1 Reagents: Potassium Hydroxide,Hydrogen Peroxide Solvents: Water1.2 Reagents: Hydrochloric Acid Solvents: Water
    标题:An Improved Synthesis Of α-Methoxy-α-(Trifluoromethyl)Phenylacetic Acid (Mosher'S Acid)
    作者:Buszek,Keith R.; Sato,Nagaaki
    参考文献:Organic Preparations And Procedures International 日期:2000 卷标:32(5) 页码:488-490]

    151545-68-5 = 81655-41-6
    反应条件:1.1 Reagents: Ozone Solvents: Acetone
    标题:A Convenient Preparation Of (+/-)-α-Methoxy-α-Trifluoromethylphenylacetic Acid (Mosher'S Acid)
    作者:Chong,J. Michael; Loewith,Rob
    参考文献:Synthetic Communications 日期:1993 卷标:23(15) 页码:2145-50]

    141090-95-1 = 81655-41-6
    反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Methanol
    标题:A New And Simple Synthesis Of Mosher'S Acid
    作者:Goldberg,Yuri; Alper,Howard
    参考文献:Journal Of Organic Chemistry 日期:1992 卷标:57(13) 页码:3731-2]

    145938-92-7 = 81655-41-6
    反应条件:1.1 Reagents: Potassium Methoxide; 20 H,45 °C1.2 Reagents: Potassium Hydroxide Solvents: Methanol; < 30 °C; 3 H,25 °C1.3 Reagents: Hydrochloric Acid Solvents: Water
    标题:Synthetic Application Of 3,3-Dichloro-1,1,1-Trifluoroacetone (Dctfa) And 3,3,3-Trichloro-1,1,1-Trifluoroacetone (Tctfa) For Trifluorolactic Acid Derivatives
    作者:Ishii,Akihiro; Kanai,Masatomi; Yasumoto,Manabu; Inomiya,Kenjin; Kuriyama,Yokusu; Et Al
    参考文献:Journal Of Fluorine Chemistry 日期:2004 卷标:125(4) 页码:567-571]

    141090-95-1 = 81655-41-6
    反应条件:1.1 Reagents: Potassium Hydroxide; 50 °C
    标题:Acetic Acid,2,2,2-Trichloro-,Trimethylsilyl Ester
    作者:Sikervar,Vikas
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2014 卷标:1 页码:1-2]

    25436-07-1 + 434-45-7 = 81655-41-6
    反应条件:1.1 Reagents: Potassium Carbonate; 40 Min,150 °C1.2 Reagents: Potassium Hydroxide; 60 °C; 6 H,60 °C1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 1
    标题:The Electron Deficient Fluoroarene Mediated Synthesis Of Trifluoromethyl Ketones From Carboxylic Acids
    作者:Said,Madhukar S.; Khonde,Nilesh S.; Kumar,Pradeep; Gajbhiye,Jayant M.
    参考文献:Organic Letters 日期:2023 卷标:25(7) 页码:1094-1098]

    25436-07-1 + 434-45-7 = 81655-41-6
    反应条件:1.1 Reagents: Potassium Carbonate,18-Crown-6; 150 °C1.2 Reagents: Potassium Hydroxide Solvents: Methanol; 50 °C
    标题:18-Crown-6
    作者:Liotta,Charles L.; Berkner,Joachim
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2001 卷标:1 页码:1-4]

    80866-87-1 = 81655-41-6 [标题:Reaction Conditions
    标题:Product Subclass 13: 3-Heteroatom-Substituted Alkanoic Acids
    作者:Sartori,G.; Maggi,R.
    参考文献:Science Of Synthesis 日期:2006 卷标:20 页码:579-604]

    80866-87-1 = 81655-41-6
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water1.2 Reagents: Hydrochloric Acid Solvents: Water
    标题:Synthesis And Study Of A New Chiral Agent - (R)-(-)-β-(Trifluoromethyl)-β-Methoxy-β-Phenylethylamine
    作者:You,Tianpa; Mosher,H. S.
    参考文献:Youji Huaxue 日期:1989 卷标:9(6) 页码:518-20]

    105678-40-8 = 81655-41-6
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water
    标题:A Modified Synthesis Of Mosher'S Acid And Its Use In A Sensitive Stereoisomer Analysis Of Amino Acid Derivatives
    作者:Hull,William E.; Seeholzer,Klaus; Baumeister,Marlies; Ugi,Ivar
    参考文献:Tetrahedron 日期:1986 卷标:42(2) 页码:547-52
📜(+/-)-α-甲氧基-α-(三氟甲基)苯乙腈置于sodium Hydroxide,硫酸体系中,化学反应 9.0H,反应生成 (+/-)-α-甲氧基-α-(三氟甲基)苯乙酸
参考文献:α-甲氧基-α-(三氟甲基)-苯乙酸(莫舍氏酸)的改进合成
标题:α-甲氧基-α-(三氟甲基)-苯乙酸(莫舍氏酸)的改进合成
摘要:二.参考文献 K. Hata,1. Motoyama 和 K. Sakai,Org.准备.进行.znt.,4,180(1972).一)j.c. Klein 和 Dm Hercules,J.catal.,82,424 (1983); B) J. Isaac 和 M. Fisher,同上,101,28 (1986).j.c. Ciivagnol 和 Fy Wisctogle,J. Am. 客户.soc.,69,795 (1947).m.比尔,Chein.界.(伦敦),198 (1969).dm Hall 和 Ee Turner,.I. 化学 社会,702(1945).jg Wilson 和 Fc Hunt,Austr-Llitin J. Chum.,36,23 I7 (1 983).美国专利 3,079,435(1963 年 2 月 26 日);化学 摘要,59,6314H
DOI:10.1080/00304940009356764

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[参考文献]: Dongsheng Du, Et Al. Anti-Complement Sesquiterpenes From Viola Yedoensis. Fitoterapia. 2015 Mar:101:73-9.

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参考DOI号:10.1016/j.tetasy.2008.04.032
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