其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Acifluorfen CAS Registry Number: 50594-66-6 三氟羧草醚

CAS Name: 5-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid
Percent Composition: C 46.49%, H 1.95%, Cl 9.80%, F 15.76%, N 3.87%, O 22.12%
Literature References: Selective pre- and post-emergence herbicide. Prepn: H. O. Bayer et al., DE 2311638; eidem, US 3928416, US 4063929 (1973, 1975, 1977 all to Rohm Haas). Synthesis, activity and toxicity: W. O. Johnson et al., J. Agric. Food Chem. 26, 285 (1978). Carcinogenicity studies: J. A. Quest et al., Regul. Toxicol. Pharmacol. 10, 149 (1989).

Propyzamide CAS Registry Number: 23950-58-5 戊炔草胺

CAS Name: 3,5-Dichloro-N-(1,1-dimethyl-2-propynyl)benzamide
Additional Names: pronamidTrademarks: Kerb (Dow AgroSci.)
Percent Composition: C 56.27%, H 4.33%, Cl 27.68%, N 5.47%, O 6.25%
Literature References: Selective pre-emergence herbicide. Prepn: B. W. Horrom et al., ZA 6800090; eidem, US 3534098; US 3640699 (1969, 1970, 1972 all to Rohm Haas). Activity: K. L. Viste et al., Science 167, 280 (1970); C. Swithenbank et al., J. Agric. Food Chem. 19, 417 (1971). Metabolism: R. Y. Yih et al., Weed Sci. 18, 604 (1970); R. Y. Yih, C. Swithenbank, J. Agric. Food Chem. 19, 314, 320 (1971); J. D. Fisher, ibid. 22, 606 (1974). Carcinogenicity study: M. D. Reuber, Environ. Res. 23, 1 (1980).

Metolachlor CAS Registry Number: 51218-45-2 异丙甲草胺

CAS Name: 2-Chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl)acetamide
Additional Names: 2-chloro-6'-ethyl-N-(2-methoxy-1-methylethyl)acet-o-toluidide; a-chloro-2'-ethyl-6'-methyl-N...
Literature References: Selective pre-emergence herbicide. Prepn: C. Vogel, R. Aebi, DE 2328340; eidem, US 3937730 (1973, 1976 both to Ciba-Geigy). Synthesis of stereoisomers: B. T. Cho, Y. S. Chun, Tetrahedron: Asymmetry 3, 337 (1992). Metabolism: L. L. McGahen, J. M. Tiedje, J. Agric. Food Chem. 26, 414 (1978). ELISA determn: T. S. Lawruk et al., J. Agric. Food Chem. 41, 1426 (1993). Review: G. Chesters et al., Rev. Environ. Contam. Toxicol. 110, 1-74 (1989); of biological activity and field trials: H. R. Gerber et al., Proc. 12th Br. Weed Control Conf. 787-794 (1974).

Benfluralin CAS Registry Number: 1861-40-1 乙丁氟灵

CAS Name: N-Butyl-N-ethyl-2,6-dinitro-4-(trifluoromethyl)benzenamine
Additional Names: N-butyl-N-ethyl-a,a,a-trifluoro-2,6-dinitro-p-toluidine; N-butyl-N-ethyl-2,6-dinitro-4-trifluoromethylanil...
Literature References: Selective pre-emergence herbicide. Prepn: Q. F. Soper, US 3257190 (1966 to Lilly). Activity: E. F. Alder et al., Proc. Northeast. Weed Control Conf. 15, 298 (1961). Environmental fate: T. Golab et al., J. Agric. Food Chem. 18, 838 (1970). Soil degradn: J. H. Miller et al., Weed Sci. 23, 211 (1975); R. L. Zimdahl, S. M. Gwynn, ibid. 25, 247 (1977). Toxicity study: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

Oryzalin CAS Registry Number: 19044-88-3 消草磺灵

CAS Name: 4-(Dipropylamino)-3,5-dinitrobenzenesulfonamide
Additional Names: 3,5-dinitro-N4,N4-dipropylsulfanilamideTrademarks: Surflan (Dow AgroSci.)
Percent Composition: C 41.61%, H 5.24%, ...
Literature References: Selective pre-emergence herbicide. Prepn: Q. F. Soper, US 3367949 (1968 to Lilly). Soil degradation: T. Golab et al., Pestic. Biochem. Physiol. 5, 196 (1975); E. W. Stoller, L. M. Wax, J. Environ. Qual. 6, 124 (1977). Review: O. D. Decker, W. S. Johnson, Anal. Methods Pestic. Plant Growth Regul. 8, 433 (1976).

Isopropalin CAS Registry Number: 33820-53-0 异丙乐灵

CAS Name: 4-(1-Methylethyl)-2,6-dinitro-N,N-dipropylbenzenamine
Additional Names: 2,6-dinitro-N,N-dipropylcumidine; 4-isopropyl-2,6-dinitro-N,N-dipropylanilineTrademarks: Paarlan (Lilly)
Per...
Literature References: Selective pre-plant herbicide. Prepn: Q. F. Soper, US 3257190 (1966 to Lilly). Persistence in soil: T. Golab, W. A. Althaus, Weed Sci. 23, 165 (1975); L. L. Gingerich, R. L. Zimdahl, ibid. 24, 431 (1976); R. R. Romanowski, A. W. Libik, ibid. 26, 258 (1978).

Profluralin CAS Registry Number: 26399-36-0 环丙氟灵

CAS Name: N-(Cyclopropylmethyl)-2,6-dinitro-N-propyl-4-(trifluoromethyl)benzenamine
Additional Names: N-(cyclopropylmethyl)-a,a,a-trifluoro-2,6-dinitro-N-propyl-p-toluidine; N-cyclopropylmethyl...
Literature References: Selective pre-planting herbicide. Prepn: NL 6911565; L. L. Maravetz, US 3546295 (1969, 1970 to Esso). Persistence in soil: J. M. Kennedy et al., Weed Sci. 25, 373 (1977). Field trial: R. E. Frans et al., Arkansas, Agric. Exp. Stn., Mimeogr. Ser. 249, 1 (1977). Soil degradn: N. D. Camper et al., J. Environ. Sci. Health B15, 457 (1980). GC determn in biological samples: T. R. Edgerton et al., J. Anal. Toxicol. 9, 15 (1985).

Allidochlor CAS Registry Number: 93-71-0 2-氯-N,N-二烯丙基乙酰胺

CAS Name: 2-Chloro-N,N-di-2-propenylacetamide
Additional Names: a-chloro-N,N-diallylacetamide; N,N-diallyl-2-chloroacetamide; CDAATrademarks: Randox (Monsanto)
Percent Composition: C 55.34%,...
Literature References: Selective pre-planting or pre-emergence herbicide. Prepd from chloroacetyl chloride and diallylamine: Speziale, Hamm, J. Am. Chem. Soc. 78, 2556 (1956); eidem, J. Agric. Food Chem. 4, 518 (1956); Bruce, Hanslick, US 2844629 (1958 to Am. Home Prods.); Hamm, Speziale, US 2864683 (1958 to Monsanto). Toxicity: G. W. Bailey, J. L. White, Residue Rev. 10, 97 (1965).

Asoprisnil CAS Registry Number: 199396-76-4 (8S,11R,13S,14S,17S)-11-[4-[(E)-羟基亚氨甲基]苯基]-17-甲氧基-17-(甲氧基甲基)-13-甲基-1,2,6,7,8,11,12,14,15,16-十氢环戊烯并[a]菲-3-酮

CAS Name: [C(E)]-4-[(11b,17b)-17-Methoxy-17-(methoxymethyl)-3-oxoestra-4,9-dien-11-yl]benzaldehyde-1-oxime
Additional Names: 11b-[4-(hydroxyiminomethyl)phenyl]-17b-methoxy-17a-(methoxymethyl)es...
Literature References: Selective progesterone receptor modulator. Prepn: G. Schubert et al., EP 648778; eidem, US 5693628 (1995, 1997 both to Jenpharm). Clinical effects on menstrual and ovarian cyclicity in premenopausal women: K. Chwalisz et al., Hum. Reprod. 20, 1090 (2005). Review of pharmacology and therapeutic potential: D. DeManno et al., Steroids 68, 1019-1032 (2003); of early clinical experience: K. Chwalisz et al., Semin. Reprod. Med. 22, 113-119 (2004).

Bexarotene CAS Registry Number: 153559-49-0 蓓萨罗丁

CAS Name: 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acidTrademarks: Targretin (Ligand)
Percent Composition: C 82.72%, H 8.10%, O 9.18%
Literature References: Selective retinoid X receptor (RXR) agonist. Prepn: M. F. Boehm et al., WO 9321146 (1993 to Ligand Pharm.); M. L. Dawson et al., US 5466861 (1995 to SRI Int.; La Jolla Cancer Res. Found.); and structure-activity study: M. F. Boehm et al., J. Med. Chem. 37, 2930 (1994); M. I. Dawson et al., ibid. 38, 3368 (1995). Chemopreventive effect in rat mammary carcinoma: M. M. Gottardis et al., Cancer Res. 56, 5566 (1996). Effect on glucose homeostasis in exptl diabetes: R. Mukherjee et al., Nature 386, 407 (1997). Clinical pharmacokinetics and evaluation in advanced cancers: V. A. Miller et al., J. Clin. Oncol. 15, 790 (1997). Clinical evaluation in cutaneous T-cell lymphoma: D. Breneman et al., Arch. Dermatol. 138, 325 (2002).