其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Benzotrichloride CAS Registry Number: 98-07-7 三氯甲苯

CAS Name: (Trichloromethyl)benzene
Additional Names: a,a,a-trichlorotoluene; phenylchloroform; w,w,w-trichlorotoluene; benzenyl trichloride; toluene trichloride
Percent Composition: C 43.01%...
Literature References: Produced by chlorination of boiling toluene in the presence of light and of 2% phosphorus trichloride: Swarts, Bull. Soc. Chim. Belg. 31, 375 (1922); Conklin, US 1828858; US 1828859 (both 1931 to Solvay Process Co.). Commercial grades may contain hydrochloric acid, benzylidene chloride, and benzyl chloride. Purification procedures: Holleman, deMooy, Rec. Trav. Chim. 33, 25, 33 (1914); Britton, US 1804458 (1931 to Dow); Chem. Zentralbl. 1931, II, 497. Toxicity data: H. F. Smyth et al., Arch. Ind. Hyg. Occup. Med. 4, 119 (1951). Review: H. C. Lin in Kirk-Othmer Encyclopedia of Chemical Technology vol. 6 (John Wiley Sons, New York, 4th ed., 1993) pp 113-126.

Dihydroxyacetone CAS Registry Number: 96-26-4 1,3-二羟基丙酮

CAS Name: 1,3-Dihydroxy-2-propanone
Additional Names: 1,3-dihydroxydimethyl ketone
Trademarks: Protosol; Ketochromin
Percent Composition: C 40.00%, H 6.71%, O 53.28%
Literature References: Produced from glycerol by Acetobacter sp. under aerobic conditions: Bernhauer, Schoen, Z. Physiol. Chem. 177, 107 (1928); Rutten, Rec. Trav. Chim. 70, 449 (1951); Bousfield et al., J. Inst. Brew. 53, 258 (1947); US 2948658 (1960 to Baxter). Review: Chem. Eng. News 38, 62 (Feb. 22, 1960), 54 (Aug. 15, 1960).

Sodium Arsenite CAS Registry Number: 7784-46-5 亚砷酸钠

Additional Names: Sodium meta-arsenite
Percent Composition: As 57.23%, H 0.77%, Na 17.56%, O 24.44%
Literature References: Product of commerce is 95-98% pure. Toxicity study: H. F. Smyth et al., Am. Ind. Hyg. Assoc. J. 30, 470 (1969). Review of toxicology and human exposure: Toxicological Profile for Arsenic (PB2000-108021, 2000) 468 pp.

Allopregnane-3 a ,20 a -diol CAS Registry Number: 566-58-5 5α-孕烷-3α,20α-二醇

CAS Name: (3a,5a,20S)-Pregnane-3,20-diol
Additional Names: 5a-pregnane-3a,20a-diol; 3a,20a-dihydroxy-5a-pregnane
Percent Composition: C 78.69%, H 11.32%, O 9.98%
Literature References: Progesterone metabolite. Isoln from human pregnancy urine: Beall, Biochem. J. 31, 35 (1937); from bulls' urine: Marker et al., J. Am. Chem. Soc. 60, 2931 (1938). Prepn by reduction of 5a-pregn-1-ene-3,20-dione with lithium aluminum hydride: Schütt, Tamm, Helv. Chim. Acta 41, 1751 (1958).

Allopregnane-3 b ,20 b -diol CAS Registry Number: 516-53-0 别孕甾烷二醇

CAS Name: (3b,5a,20R)-Pregnane-3,20-diol
Additional Names: 3b,20b-dihydroxy-5a-pregnane
Percent Composition: C 78.69%, H 11.32%, O 9.98%
Literature References: Progesterone metabolite. Isoln from pregnant mares' urine: Brooks et al., Biochem. J. 51, 694 (1952). Prepn by catalytic reduction of allopregnane-3,20-dione: Marker et al., GB 512940 (1939 to Parke, Davis); by hydrogenation of pregn-5-ene-3b-ol-20-one: Klyne, Barton, J. Am. Chem. Soc. 71, 1500 (1949); by hydrogenation of pregn-5-ene-3b,20b-diol: Klyne, Miller, J. Chem. Soc. 1950, 1972.

Allopregnane-3 b ,20 a -diol CAS Registry Number: 566-56-3 5α-孕烷-3β,20(S)-二醇

CAS Name: (3b,5a,20S)-Pregnane-3,20-diol
Additional Names: 5a-pregnane-3b,20a-diol; 3b,20a-dihydroxy-5a-pregnane
Percent Composition: C 78.69%, H 11.32%, O 9.98%
Literature References: Progesterone metabolite. Isoln from pregnant mares' urine: Brooks et al., Biochem. J. 51, 694 (1952). Prepn by heating 3a,20a-dihydroxy-5a-pregnane with sodium, or by hydrogenation of 5a-pregnane-20-ol-3-one in acid: Marker, US 2196220 and US 2250962 (1940, 1941, both to Parke, Davis); by reduction of allopregnan-3b-ol-20-one acetate with sodium: Klyne, Barton, J. Am. Chem. Soc. 71, 1500 (1949); by reduction of 5,16-pregnadien-3b-ol-20-one with Zn + acetic acid: Ercoli, De Ruggieri, Farm. Sci. Tec. 7, 11 (1952), C.A. 46, 10186b (1952).

Allopregnane-3 a ,20 b -diol CAS Registry Number: 566-57-4 5-Alpha-孕烷-3-alpha, 20-beta-二醇

CAS Name: (3a,5a,20R)-Pregnane-3,20-diol
Additional Names: 3a,20b-dihydroxy-5a-pregnane
Percent Composition: C 78.69%, H 11.32%, O 9.98%
Literature References: Progesterone metabolite. Prepn by hydrogenation of progesterone: Marker, Lawson, J. Am. Chem. Soc. 61, 588 (1939); by catalytic hydrogenation of epiallopregnane-3-ol-20-one: Marker, US 2231019 (1941 to Parke, Davis); by reduction of 5a-pregn-1-ene-3,20-dione with lithium aluminum hydride: Schütt, Tamm, Helv. Chim. Acta 41, 1751 (1958).

Mifepristone CAS Registry Number: 84371-65-3 米非司酮

CAS Name: (11b,17b)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
Additional Names: 11b-[4-(N,N-dimethylamino)phenyl]-17a-(prop-1-ynyl)-D4,9-estradiene-17b-ol-3-on...
Literature References: Progesterone receptor antagonist with partial agonist activity. Prepn: J. G. Teutsch et al., EP 57115; eidem, US 4386085 (1982, 1983 both to Roussel-UCLAF). Pharmacology: W. Herrmann et al., C.R. Seances Acad. Sci. Ser. 3 294, 933 (1982). Pituitary and adrenal responses in primates: D. L. Healy et al., J. Clin. Endocrinol. Metab. 57, 863 (1983). Mechanism of action study: M. Rauch et al., Eur. J. Biochem. 148, 213 (1985). Clinical study as abortifacient: B. Couzinet et al., N. Engl. J. Med. 315, 1565 (1986); as postcoital contraceptive: A. Glasier et al., ibid. 327, 1041 (1992). Review of mechanism of action and clinical applications: E. E. Baulieu, Science 245, 1351-1357 (1989). Reviews: I. M. Spitz, C. W. Bardin, N. Engl. J. Med. 329, 404-412 (1993); R. N. Brogden et al., Drugs 45, 384-409 (1993).

Onapristone CAS Registry Number: 96346-61-1 奥那司酮

CAS Name: (11b,13a,17a)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(3-hydroxypropyl)estra-4,9-dien-3-one
Additional Names: 11b-(4-dimethylaminophenyl)-17a-hydroxy-17b-(3-hydroxypropyl)-13a-meth...
Literature References: Progesterone receptor antagonist. Prepn: G. Neef et al., EP 129499; eidem, US 4780461 (1984, 1988 both to Schering AG); idem et al., Steroids 44, 349 (1984). HPLC determn in plasma and serum: C. Zurth, F. Kagels, J. Chromatogr. 532, 115 (1990). In vitro effect on breast cancer cells: S. Classen et al., J. Steroid Biochem. Mol. Biol. 45, 315 (1993). Mechanism of action study: D. P. Edwards et al., ibid. 53, 449 (1995). Clinical antifolliculotrophic effect: H. B. Croxatto et al., Hum. Reprod. 9, 1442 (1994).

Desogestrel CAS Registry Number: 54024-22-5 去氧孕烯

CAS Name: (17a)-13-Ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol
Additional Names: 17a-ethynyl-18-methyl-11-methylene-D4-estren-17b-olTrademarks: Cerazette (Organon)
Percent Compositi...
Literature References: Progestogen with low androgenic potency. Prepn: A. J. van den Broek, DE 2361120; idem, US 3927046 (1974, 1975 both to Akzo); A. J. van den Broek et al., Rec. Trav. Chim. 94, 36 (1975). Biological effects: L. Viinikka et al., Acta Endocrinol. 83, 429 (1976). Endocrinological studies in animals: J. van der Vies, J. de Visser, Arzneim.-Forsch. 33, 231 (1983). Radioimmunoassay: L. Viinikka, J. Steroid Biochem. 9, 979 (1978). Metabolism, pharmacokinetics in humans: L. Viinikka et al., Eur. J. Clin. Pharmacol. 15, 349 (1979). Receptor binding study: E. W. Bergink et al., J. Steroid Biochem. 14, 175 (1981). Clinical trial in combination with ethinyl estradiol: M. J. Weijers, Clin. Ther. 4, 359 (1982); as progestogen-only contraceptive: T. Korver et al., Eur. J. Contracept. Reprod. Health Care 3, 169 (1998).