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项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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Homoserine CAS Registry Number: 672-15-1 L-高丝氨酸

Additional Names: 2-Amino-4-hydroxybutanoic acid; 2-amino-4-hydroxybutyric acid; a-amino-g-hydroxy-n-butyric acid
Percent Composition: C 40.33%, H 7.62%, N 11.76%, O 40.29%
Literature References: Principal free amino acid occurring in pea plants: A. I. Virtanen, Acta Chem. Scand. 7, 1423 (1953); J.A. Bakhuis, Nature 180, 713 (1957). Prepn: Fischer, Blumenthal, Ber. 40, 106 (1907); Armstrong J. Am. Chem. Soc. 70, 1756 (1948); Birnbaum, Greenstein, Arch. Biochem. Biophys. 42, 212 (1953); M. Frankel, Y. Knobler, J. Am. Chem. Soc. 80, 3147 (1958). Review of homoserine production by fermentation: T. Nara in Microbial Prod. Amino Acids, K. Yamada, Ed. (Wiley, New York, 1972) pp 417-434.

Hydrocortisone CAS Registry Number: 50-23-7 氢化可的松

CAS Name: (11b)-11,17,21-Trihydroxypregn-4-ene-3,20-dione
Additional Names: cortisol; 4-pregnene-11b,17a,21-triol-3,20-dione; 17-hydroxycorticosterone; anti-inflammatory hormone; Kendall's comp...
Literature References: Principal glucocorticoid hormone produced by the adrenal cortex. Biosynthesis stimulated by ACTH, q.v. Circulates in plasma primarily bound to corticosteroid-binding globulin, also known as transcortin, and to albumin. Isoln from adrenal glands: Reichstein, Helv. Chim. Acta 20, 953 (1937); Mason et al., J. Biol. Chem. 124, 459 (1938); from urine: Mason, Sprague, ibid. 175, 451 (1948); from blood: Reich et al., ibid. 187, 411 (1950). Configuration: von Euw, Reichstein, Helv. Chim. Acta 25, 988 (1942); 30, 205 (1947). Synthesis: N. L. Wendler et al., J. Am. Chem. Soc. 72, 5793 (1950). Biosynthesis by isolated adrenal glands: O. Hechter et al., Arch. Biochem. Biophys. 25, 457 (1950); A. Zaffaroni et al., J. Am. Chem. Soc. 73, 1390 (1951). Prepn by microbial transformation: H. C. Murray, D. H. Peterson, US 2602769 (1952 to Upjohn); D. R. Colingsworth et al., J. Biol. Chem. 203, 807 (1953). Total biosynthesis in yeast: F. M. Szczebara et al., Nat. Biotechnol. 21, 143 (2003). Comprehensive description: K. Florey, Anal. Profiles Drug Subs. 12, 277-324 (1983). Review of clinical use in dermatoses: A. M. Kligman, K. H. Kaidbey, Cutis 22, 232-244 (1978). Review of clinical assays in serum and urine: A. Moore et al., Ann. Clin. Biochem. 22, 435-454 (1985). Physiological role in immunity: W. M. Jefferies, Med. Hypotheses 34, 198-208 (1991); in fetal maturation: G. C. Liggins, Reprod. Fertil. Dev. 6, 141-150 (1994).

Coniferin CAS Registry Number: 531-29-3 松柏苷; 松苷

CAS Name: 4-(3-Hydroxy-1-propenyl)-2-methoxyphenyl b-D-glucopyranoside
Additional Names: 4-hydroxy-3-methoxy-1-(g-hydroxypropenyl)benzene-4-D-glucoside; abietin; laricin
Percent Composition:...
Literature References: Principal glucoside of the conifers. Also in comfrey root, sugar beet, and asparagus. Extraction from the cambium layer of fir: Solntsev, C.A. 38, 3780 (1944). Synthesis: Pauley, Feuerstein, Ber. 60, 1031 (1927). Hydrolysis by emulsin yields coniferyl alcohol and D-glucose. Yields lignin-like material by enzymatic dehydrogenation and polymerization: Freudenberg et al., Ber. 85, 641 (1952); Freudenberg, Rasenack, Ber. 86, 756 (1953).

Tremetone CAS Registry Number: 4976-25-4 (-)-丙呋甲酮

CAS Name: 1-[2,3-Dihydro-2-(1-methylethenyl)-5-benzofuranyl]ethanone
Additional Names: 2,3-dihydro-2-isopropenyl-5-benzofuranyl methyl ketone; 2-isopropenyl-2,3-dihydro-5-acetylbenzofuran
Pe...
Literature References: Principal ketone suspected of being the active toxin of Eupatorium urticaefolium Reichard, Compositae (white snakeroot). Isoln and structure: Bonner, DeGraw, Tetrahedron 18, 1295 (1962). Synthesis of dihydrotremetone: DeGraw, Bonner, ibid. 1311. Synthesis of racemic tremetone: DeGraw et al., ibid. 19, 19 (1963); Bohlmann, Buehmann, Ber. 105, 863 (1972). Abs config: Bonner et al., Tetrahedron 20, 1419 (1964). Review: Christensen, Econ. Bot. 19, 293-300 (1965).

Rottlerin CAS Registry Number: 82-08-6 粗糠柴苦素

CAS Name: (E)-1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one
Additional Names: 5,7-dihydroxy-2,2-dimethyl-6-(2,...
Literature References: Principal phenolic component of kamala, q.v., an anthelmintic dye obtained from Mallotus philippinensis (Lam.) Muell. Arg. (also known as Rottlera tinctoria Roxb.), Euphorbiaceae. Isoln: H. Telle, Arch. Pharm. 244, 446 (1906); S. Dutt, J. Chem. Soc. 127, 2044 (1925); A. McGookin et al., ibid. 1937, 748. Structure: Brockmann, Maier, Ann. 535, 149 (1938); A. McGookin et al., J. Chem. Soc. 1939, 1579. Synthesis of tetrahydrorottlerin: Backhouse et al., ibid. 1948, 113. Review of isoln and chemistry: M. Lounasmaa et al., Planta Med. 28, 16 (1975). Activity as protein kinase inhibitor: M. Gschwendt et al., Biochem. Biophys. Res. Commun. 199, 93 (1994). HPTLC determn in serum and pharmacokinetics: V. D. Mody et al., J. Pharm. Technol. 10, 71 (1994).

Ergoflavin CAS Registry Number: 3101-51-7 (1S,1'S,10R,10'R,11S,11'S,13S,13'S,14S,14'S)-7,7',10,10',14,14'-六羟基-13,13'-二甲基-6,6'-联(2,16-二氧杂四环[9.3.2.01,10.03,8]十六烷)-3,3',5,5',7,7'-己烯-9,9',15,15'-四酮

CAS Name: (1S,1'S,3S,3'S,4S,4'S,4aS,4'aS,9aR,9'aR)-1,1',3,3',4,4',9a,9'a-Octahydro-4,4',8,8',9a,9'a-hexahydroxy-3,3'-dimethyl-[7,7'-bi-1,4a-(epoxymethano)-4aH-xanthene]-9,9',11,11'(2H,2'H)-tetrone...
Literature References: Principal pigment from ergot: Freeborn, Pharm. J. 88, 568 (1912); Eglinton et al., J. Chem. Soc. 1958, 1833. Structure: McPhail et al., ibid. 1966, Sect. B, 18. Review of ergoflavin and other ergochromes: Franck, Flasch in Fortschr. Chem. Org. Naturst. 30, 151-206 (1973).

g -Sitosterol CAS Registry Number: 83-47-6 γ-谷甾醇

CAS Name: (3b,24S)-Stigmast-5-en-3-ol
Additional Names: clionasterol
Percent Composition: C 83.99%, H 12.15%, O 3.86%
Literature References: Principal sterol of soybean oil: Bonstedt, Z. Physiol. Chem. 176, 269 (1928). Isoln from corn oil: Anderson, Shriner, J. Am. Chem. Soc. 48, 2976 (1926); from venom of Chinese toad, Bufo gargarizans: Rukstuhl, Meyer, Helv. Chim. Acta 40, 1270 (1957). Differs from b-sitosterol in spatial configuration at C-24: Bergmann, Low, J. Org. Chem. 12, 67 (1947). Structure: Pavanaram, Helv. Chim. Acta 46, 1377 (1963). Stereospecific synthesis: W. Sucrow, M. Slopianka, Ber. 108, 3721 (1975).

Kermesic Acid CAS Registry Number: 18499-92-8

CAS Name: 9,10-Dihydro-3,5,6,8-tetrahydroxy-1-methyl-9,10-dioxo-2-anthracenecarboxylic acid
Additional Names: C.I. Natural Red 3; C.I. 75460
Percent Composition: C 58.19%, H 3.05%, O 38.76%
Literature References: Principle constituent of kermes, one of the oldest known insect dyes. Isoln and characterization: O. Dimroth, Ber. 43, 1387 (1910); O. Dimroth, W. Scheurer, Ann. 399, 43 (1913). Structure: O. Dimroth, R. Fick, Ann. 411, 315 (1916). Revised structure: D. D. Gadgil et al., Tetrahedron Lett. 1968, 2223. Synthesis: D. W. Cameron et al., Chem. Commun. 1978, 688; eidem, Aust. J. Chem. 34, 2401 (1981).

Pepsin CAS Registry Number: 9001-75-6 胃蛋白酶(猪源)

Trademarks: Puerzym (Firma)
Literature References: Principle digestive enzyme of gastric juice; controls the degradation of proteins to proteoses and peptones. Distinctive among enzymes for having a very low isoelectric point and a very low pH optimum. Hydrolyzes only peptide linkages. The N.F. grade digests not less than 3000 or more than 3500 times its wt of freshly coagulated and disintegrated egg albumin in 2½ hours at 52° in water acidulated with HCl. Isoln from gastric juice of swine and beef: Northrup, J. Gen. Physiol. 13, 739 (1930); 16, 615 (1933); from salmon and tuna: Norris, Edam, J. Biol. Chem. 134, 443 (1940); 204, 673 (1953). Amino acid composition: Brand in Crystalline Enzymes, J. H. Northrup et al. (Columbia Univ. Press, New York, 2nd ed., 1948) p 26. Active site: Herriott, J. Gen. Physiol. 45, Suppl., 57 (1962). Review: Bovey, Yanari in The Enzymes vol. 4, P. D. Boyer et al., Eds. (Academic Press, New York, 1960) pp 63-92.

Hexaminolevulinate CAS Registry Number: 140898-97-1 戊酸,5-氨基-4-氧-,己酯

CAS Name: 5-Amino-4-oxopentanoic acid hexyl ester
Additional Names: 5-aminolevulinic acid hexyl ester; hexyl 5-aminolevulinate
Percent Composition: C 61.37%, H 9.83%, N 6.51%, O 22.29%
Literature References: Prodrug of d-aminolevulinic acid, q.v.; induces production of intracellular protoporphyrin IX. Prepn: H. Takeya, JP Kokai 92 9360 (1992 to Cosmo Sogo Kenkyusho); and use as photosensitizer: K. E. Gierskcky et al., WO 9628412 (1996 to Norwegian Radium Res. Found.); eidem, US 6034267 (2000 to PhotoCure). Synthesis and pharmacology: C. J. Whitaker et al., Anti-Cancer Drug Des. 15, 161 (2000). Clinical evaluation for photodetection of bladder cancer: N. Lange et al., Br. J. Cancer 80, 185 (1999).