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项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点:源头优选:利用如N-硝胺化学等底层方法学突破,从分子层面颠覆传统高成本、高污染路线。过程强化:依托连续流技术,攻克有机金属试剂应用、光化学反应放大等“不可能”任务,实现高危工艺的本质安全。系统集成:整合“反应-淬灭-分离”全流程,利用微流控与在线分析技术,消除批次间的差异,实现药品制造的连续化与智能化。当前,中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合,将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势,将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

  • Caroverine CAS Registry Number: 23465-76-1 卡罗维林


    CAS Name: 1-[2-(Diethylamino)ethyl]-3-[(4-methoxyphenyl)methyl]-2(1H)-quinoxalinone
    Additional Names: 1-(diethylaminoethyl)-3-(p-methoxybenzyl)dihydro-2-quinoxalone
    Trademarks: Spasmium (Don...
    Literature References: Prepn: Zellner et al., US 3028384 (1962 to Donau-Pharm.). Polarographic study: P. Pflegel, Pharmazie 24, 667 (1969). Pharmacological study: F. Hahn et al., Arch. Int. Pharmacodyn. Ther. 199, 108 (1972).

  • Tridecylbenzene CAS Registry Number: 123-02-4 十三烷基苯


    CAS Name: 1-Phenyltridecane
    Additional Names: Detergent Alkylate #5
    Trademarks: Tridane
    Percent Composition: C 87.62%, H 12.38%
    Literature References: Prepn: Ziegler et al., Ann. 511, 13 (1934). Manufacture: Williamson, Bieneman, US 3207800 (1965 to Continental Oil).

  • Methitural CAS Registry Number: 467-43-6 美西妥拉


    CAS Name: Dihydro-5-(1-methylbutyl)-5-[2-(methylthio)ethyl]-2-thioxo-4,6(1H,5H)-pyrimidinedione
    Additional Names: 5-(1-methylbutyl)-5-[2-(methylthio)ethyl]-2-thiobarbituric acid; 5-(2-methylthi...
    Literature References: Prepn: Zima, Von Werder, US 2802827 (1957 to E. Merck).

  • DDD (Analytical) CAS Registry Number: 6088-51-3 双(6-羟基-2-萘)二硫


    CAS Name: 6,6'-Dithiobis-2-naphthalenol
    Additional Names: 6,6'-dithiodi-2-naphthol; bis(6-hydroxy-2-naphthyl) disulfide; 2,2'-dihydroxy-6,6'-dinaphthyl disulfide; 6,6'-dithiobis(2-naphthol)
    ...
    Literature References: Prepn: Zincke, Dereser, Ber. 51, 352 (1918).

  • Oxalenediuramidoxime CAS Registry Number: 580-52-9 (1E,2E)-N'1,N'2-二氨基甲酰-N1,N2-二羟基乙烷二脒


    CAS Name: N,N''-Bis(aminocarbonyl)-N',N'''-dihydroxyethanediimidamide
    Percent Composition: C 23.53%, H 3.95%, N 41.17%, O 31.35%
    Literature References: Prepn: Zinkeisen, Ber. 1889, 2952.

  • Chelidonic Acid CAS Registry Number: 99-32-1 白屈菜酸


    CAS Name: 4-Oxo-4H-pyran-2,6-dicarboxylic acid
    Additional Names: 4-oxo-1,4-pyran-2,6-dicarboxylic acid; Jerva acid; jervasic acid
    Percent Composition: C 45.67%, H 2.19%, O 52.14%
    Literature References: Presence in various plants: Stransky, Arch. Pharm. 258, 56 (1920); Ramstad, Pharm. Acta Helv. 28, 45 (1953). Structure: Verkade, Recl. Trav. Chim. Pays-Bas 43, 879 (1924). Synthesis: Riegel, Reinhard, J. Am. Chem. Soc. 48, 1334 (1926); Riegel, Zwilgmeyer, Org. Synth. coll. vol. II, 126 (1943); Toomey, Riegel, J. Org. Chem. 17, 1492 (1952).

  • Fructose-6-phosphate CAS Registry Number: 643-13-0 果糖-6-磷酸


    CAS Name: D-Fructose 6-(dihydrogen phosphate)
    Additional Names: D-fructose-6-phosphoric acid; fructose monophosphate; hexose phosphate; hexose monophosphate; Neuberg ester
    Percent Compositio...
    Literature References: Present in animal tissues as an equilibrium mixture with glucose-6-phosphate. The glucose-6-phosphate may be reversibly transformed into fructose-6-phosphate by the enzyme phosphohexose isomerase. Prepn by hydrolysis of 1,6-fructose diphosphate with dil acid: Neuberg, Biochem. Z. 88, 432 (1917); DE 334250 (Bayer); Chem. Zentralbl. 1921, II, 961; Frdl. 13, 948. Role in metabolic regulation and heat generation: E. A. Newsholme, Biochem. Soc. Trans. 4, 978 (1976).

  • Methyl Salicylate CAS Registry Number: 119-36-8 水杨酸甲酯


    CAS Name: 2-Hydroxybenzoic acid methyl ester
    Additional Names: wintergreen oil; betula oil; sweet birch oil; teaberry oil
    Percent Composition: C 63.15%, H 5.30%, O 31.55%
    Literature References: Present in leaves of Gaultheria procumbens L., Ericaceae, in the bark of Betula lenta L., Betulaceae; prepd by esterification of salicylic acid with methanol. Toxicity data: P. M. Jenner et al., Food Cosmet. Toxicol. 2, 327 (1964).

  • Tristearin CAS Registry Number: 555-43-1 三硬脂酸甘油酯


    CAS Name: Octadecanoic acid 1,2,3-propanetriyl ester
    Additional Names: stearin; glyceryl tristearate
    Percent Composition: C 76.79%, H 12.44%, O 10.77%
    Literature References: Present in many animal and vegetable fats, especially the hard ones like cacao butter and tallow. Prepd from stearic acid and glycerol in the presence of Al2O3: Ingram, GB 663566 (1951 to I.C.I.); by catalytic hydrogenation of many oils: Bailey's Industrial Oil and Fat Products (Wiley, New York, 3rd ed., 1964) pp 881-882.

  • Hercynine CAS Registry Number: 534-30-5


    CAS Name: (aS)-a-Carboxy-N,N,N-trimethyl-1H-imidazole-4-ethanaminium inner salt
    Additional Names: L-(1-carboxy-2-imidazol-4-ylethyl)trimethyl ammonium hydroxide inner salt; histidine-betaine; h...
    Literature References: Present in many fungi, especially in Amanita muscaria Fr. and Agaricus campestris L., Agaricaceae. Isoln: Kutscher, Zentralbl. Physiol. 24, 775 (1910); 26, 569 (1912); Barger, Ewins, J. Chem. Soc. 99, 2340 (1911); Küng, Z. Physiol. Chem. 91, 249 (1914). Occurrence in the Limulus polyphemus L. (king crab), and prepn: Ackermann, List, ibid. 313, 30 (1958). Synthesis: Reinhold et al., J. Med. Chem. 11, 258 (1968). Biosynthesis by fungi and Actinomycetales: Genghof, J. Bacteriol. 103, 475 (1969).

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