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    • 项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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    其它产品项目整合

  • Aluminum Bis(acetylsalicylate) CAS Registry Number: 23413-80-1 乙酰水杨酸铝


    CAS Name: Bis[2-(acetyloxy)benzoato-O']hydroxyaluminum
    Additional Names: hydroxybis(acetylsalicylato)aluminum; aluminum diacetylsalicylate; aluminum acetylsalicylate N.F.; acetylsalicylate alum...
    Literature References: Prepn: Wolf, US 1967649 (1934 to Chinoin); GB 826299 (1959 to Lewis-Howe).

  • Cupric Hexafluorosilicate CAS Registry Number: 12062-24-7 氟硅酸铜


    Additional Names: Cupric fluosilicate; cupric silicofluoride
    Percent Composition: Cu 30.90%, F 55.44%, Si 13.66%
    Literature References: Prepn: Worthington, Haring, Ind. Eng. Chem. Anal. Ed. 3, 7 (1931).

  • Pramoxine CAS Registry Number: 140-65-8 丙吗卡因


    CAS Name: 4-[3-(4-Butoxyphenoxy)propyl]morpholine
    Additional Names: p-butoxyphenyl g-morpholinopropyl ether; g-morpholinopropyl 4-n-butoxyphenyl ether; pramocaine; proxazocain
    Percent Compos...
    Literature References: Prepn: Wright, Moore, J. Am. Chem. Soc. 73, 2281 (1951); 76, 4396 (1954); US 2870151 (1959 to Abbott). Pharmacology: O. Blanpin, Anesth. Analg. Reanimat. 14, 225 (1957). Toxicity studies: J. L. Schmidt et al., Toxicol. Appl. Pharmacol. 1, 454 (1959); S. Monash, D. Gibbs, Anesth. Analg. 38, 265 (1959).

  • Ammonium Phosphotungstate CAS Registry Number: 1311-90-6 磷钨酸铵


    CAS Name: Ammonium tungstophosphate
    Additional Names: ammonium phosphowolframate
    Percent Composition: H 0.41%, N 1.43%, O 21.83%, P 1.06%, W 75.26%
    Literature References: Prepn: Wu, J. Biol. Chem. 43, 189 (1920); Healy. Radiochim. Acta 2, 146 (1964).

  • Anthralin CAS Registry Number: 1143-38-0 1,8,9-三羟基蒽


    CAS Name: 1,8-Dihydroxy-9(10H)-anthracenone
    Additional Names: 1,8-dihydroxyanthrone; dithranol
    Trademarks: Anthraforte (Stiefel); Anthranol (Stiefel); Anthrascalp (Stiefel); Antraderm (Prote...
    Literature References: Prepn: Y. Hirosé, Ber. 45, 2474 (1912); K. Zahn, H. Koch, ibid. 71B, 172 (1938). Revised structure: H. M. Avdovich, G. A. Neville, Can. J. Spectrosc. 25, 110 (1980); F. R. Ahmed, Acta Crystallogr. B36, 3184 (1980). Historical review: R. E. Ashton et al., J. Am. Acad. Dermatol. 9, 173-192 (1983). Review of mechanism of action: L. Kemény et al., Skin Pharmacol. 3, 1-20 (1990); of clinical pharmacology and efficacy in psoriasis: G. Mahrle, Clin. Dermatol. 15, 723-737 (1997).

  • Triflupromazine CAS Registry Number: 146-54-3 三氟丙嗪


    CAS Name: N,N-Dimethyl-2-(trifluoromethyl)-10H-phenothiazine-10-propanamine
    Additional Names: 10-[3-(dimethylamino)propyl]-2-trifluoromethylphenothiazine; 2-trifluoromethyl-10-(g-dimethylaminop...
    Literature References: Prepn: Yale et al., J. Am. Chem. Soc. 79, 4375 (1957); GB 813861 (1959 to SK F). Comprehensive description of the hydrochloride: K. Florey, Anal. Profiles Drug Subs. 2, 523-550 (1973).

  • Prothipendyl CAS Registry Number: 303-69-5 丙硫喷地


    CAS Name: N,N-Dimethyl-10H-pyrido[3,2-b][1,4]benzothiazine-10-propanamine
    Additional Names: 10-(3-dimethylaminopropyl)-10H-pyrido[3,2-b][1,4]benzothiazine; 10-(g-dimethylaminopropyl)-1-azapheno...
    Literature References: Prepn: Yale, Bernstein, US 2943086 (1960 to Olin Mathieson); von Schlichtegroll, Proc. 1st Int. Congr. Neuro-Pharm. 1958, 408 (1959), C.A. 54, 13400g (1960); FR 1173134 (1959 to Rhône-Poulenc).

  • Cicrotoic Acid CAS Registry Number: 25229-42-9 环丁烯酸


    CAS Name: b-Methylcyclohexaneacrylic acid
    Additional Names: b-cyclohexyl-b-methacrylic acid; 3-cyclohexyl-2-butenoic acid; b-methylcyclohexanepropenoic acidTrademarks: Accroibile (Thžaplix)
    ...
    Literature References: Prepn: Young et al., J. Org. Chem. 28, 928 (1963); Redel, Raymond, FR M4665 (1967 to Soc. Chim. Org. Biol.), C.A. 72, 42949h (1970).

  • Rimazolium Metilsulfate CAS Registry Number: 28610-84-6 甲硫利马唑


    CAS Name: 3-(Ethoxycarbonyl)-6,7,8,9-tetrahydro-1,6-dimethyl-4-oxo-4H-pyrido[1,2-a]pyrimidinium methyl sulfate
    Additional Names: 3-carboxy-6,7,8,9-tetrahydro-1,6-dimethyl-4-oxo-4H-pyrido[1,2-a]...
    Literature References: Prepn: Z. Mészáros et al., HU Teljes 519 (1970 to Chinoin), C.A. 74, 42374h (1971); eidem, Arzneim.-Forsch. 22, 815 (1972). Anti-inflammatory and analgesic effects in animals: K. Gyires et al., Drugs Exp. Clin. Res. 11, 493 (1985). Clinical analgesic effect: H. Graber, Int. J. Clin. Pharmacol. Ther. Toxicol. 6, 354 (1972); M. Haataja et al., Curr. Ther. Res. 22, 784 (1977). Series of articles on pharmacology, pharmacodynamics and toxicology: Arzneim.-Forsch. 21, 717-738 (1971). Toxicity data: J. Knoll et al., ibid. 719.

  • Androisoxazole CAS Registry Number: 360-66-7 雄异恶唑


    CAS Name: (5a,17b)-17-Methylandrostano[3,2-c]isoxazol-17-ol
    Additional Names: 2,3,3a,3b,4,5,5a,6,10,10a,10b,11,12,12a-tetradecahydro-1,10a,12a-trimethyl-1H-cyclopenta[7,8]phenanthro[2,3-c]isoxa...
    Literature References: Prepn: Zderic et al., Chem. Ind. (London) 1960, 1625.

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