Pepsin CAS Registry Number: 9001-75-6 胃蛋白酶(猪源)

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Literature References: Principle digestive enzyme of gastric juice; controls the degradation of proteins to proteoses and peptones. Distinctive among enzymes for having a very low isoelectric point and a very low pH optimum. Hydrolyzes only peptide linkages. The N.F. grade digests not less than 3000 or more than 3500 times its wt of freshly coagulated and disintegrated egg albumin in 2½ hours at 52° in water acidulated with HCl. Isoln from gastric juice of swine and beef: Northrup, J. Gen. Physiol. 13, 739 (1930); 16, 615 (1933); from salmon and tuna: Norris, Edam, J. Biol. Chem. 134, 443 (1940); 204, 673 (1953). Amino acid composition: Brand in Crystalline Enzymes, J. H. Northrup et al. (Columbia Univ. Press, New York, 2nd ed., 1948) p 26. Active site: Herriott, J. Gen. Physiol. 45, Suppl., 57 (1962). Review: Bovey, Yanari in The Enzymes vol. 4, P. D. Boyer et al., Eds. (Academic Press, New York, 1960) pp 63-92.