其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Djenkolic Acid CAS Registry Number: 498-59-9 3,3'-(亞甲二硫)雙丙胺酸

CAS Name: S,S'-Methylenebis-L-cysteine
Additional Names: 3,3'-(methylenedithio)dialanine; 3,3'-methylenedithiobis(2-aminopropanoic acid); L-cysteine thioacetal of formaldehyde
Percent Compos...
Literature References: An amino acid isolated from the djenkol bean (Pithecolobium lobatum Benth., Leguminosae): van Veen, Hyman, Rec. Trav. Chim. 54, 493 (1935). Synthesis from 1 mol formaldehyde and 2 mols L-cysteine in strong HCl solution: Armstrong, du Vigneaud, J. Biol. Chem. 168, 373 (1947); cf. du Vigneaud, Patterson, ibid. 114, 633 (1936); Middlebrook, Phillips, Biochem. J. 41, 218 (1947). Synthesis of homologs: Frankel, Gertner, J. Chem. Soc. 1960, 898.

Mycosamine CAS Registry Number: 527-38-8

CAS Name: 3-Amino-3,6-dideoxymannose
Additional Names: 3-amino-3-deoxyrhamnose; 3,6-dideoxy-3-amino-D-mannopyranose; 3-amino-3,6-dideoxy-D-aldohexose
Percent Composition: C 44.17%, H 8.03%, ...
Literature References: An amino sugar which represents the nitrogen-contg moiety of the antifungal antibiotics, nystatin and amphotericin B, q.q.v. Isoln and structure: Dutcher et al., Antibiot. Annu. 1956-1957, 866. Walters et al., J. Am. Chem. Soc. 79, 5076 (1957); Dutcher et al., J. Org. Chem. 28, 995 (1963). Stereochemistry: von Saltza et al., J. Am. Chem. Soc. 83, 2875 (1961); eidem, J. Org. Chem. 28, 999 (1963).

D -Araboflavin CAS Registry Number: 5978-87-0 1-脱氧-1-(7,8-二甲基-2,4-二氧代-3,4-二氢苯并[g]蝶啶-10(2H)-基)-D-阿拉伯糖醇

CAS Name: 1-Deoxy-1-(3,4-dihydro-7,8-dimethyl-2,4-dioxobenzo[g]pteridin-10(2H)-yl)-D-arabinitol
Additional Names: 7,8-dimethyl-10-(arabino-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10...
Literature References: An antagonist of riboflavine. Prepd from D-(2-amino-4,5-dimethylphenyl)arabinamine and alloxan: Kuhn, Weygand, Ber. 68, 1286 (1935); Sahashi et al., Bull. Inst. Phys. Chem. Res. (Tokyo) 24, 72 (1948), C.A. 42, 5458 (1948).

Protoanemonin CAS Registry Number: 108-28-1 5-亚甲基-2(5H)-呋喃酮

CAS Name: 5-Methylene-2(5H)-furanone
Additional Names: 4-hydroxy-2,4-pentadienoic acid g-lactone; 5-methylene-2-oxodihydrofuran
Trademarks: Isomycin (Werfft)
Percent Composition: C 62.50%...
Literature References: An antibacterial principle of Anemone pulsatilla L., Ranunculaceae: Seegal, Holden, Science 101, 413 (1945). Exists as a glucoside, ranunculin, in the intact plant, and is released by an enzymatic process on maceration of the plant tissue: R. Hill, R. van Heyningen, Biochem. J. 49, 332 (1951). Isoln: Asahina, Fujita, Acta Phytochim. 1, 1 (1922); Baer et al., J. Biol. Chem. 162, 65 (1946). Structure and synthesis: Asahina, Fujita, loc. cit.; Muskat et al., J. Am. Chem. Soc. 52, 326 (1930); Fox, Jr., Proc. Soc. Exp. Biol. 51, 102 (1942); Shaw, J. Am. Chem. Soc. 68, 2510 (1946). Industrial prepns: GB 759999 (1956 to Olin Mathieson), C.A. 51, 9678f (1957); Reicheneder et al., DE 1088047 (BASF), C.A. 56, 14086i (1962); Sakuma, Hirano, US 3203863 (1965 to Lion Dentifrice).

Patulin CAS Registry Number: 149-29-1 棒曲霉素

CAS Name: 4-Hydroxy-4H-furo[3,2-c]pyran-2(6H)-one
Additional Names: clavacin; clavatin; claviformin; expansine; mycoin C3; penicidin
Percent Composition: C 54.55%, H 3.92%, O 41.52%
Literature References: An antibiotic derived from the metabolites of a number of fungi, e.g., Aspergillus clavatus, A. claviforme, A. giganteus, A. terreus, Penicillium patulum, P. expansum, P. melinii, P. leucopus, P. urticae and Gymnoascus spp. Isoln and antibacterial activity: Birkinshaw et al., Lancet 245, 625 (1943); Birkinshaw, Michael, US 2417584 (1947 to Therap. Res. Corp. of Great Britain); cf. Waksman et al., Science 96, 202 (1942); Brack, Helv. Chim. Acta 30, 1 (1947); Norstadt, McCalla, Appl. Microbiol. 17, 193 (1969). Structure: Birkinshaw, loc. cit.; Bergel et al., J. Chem. Soc. 1944, 415; Woodward, Singh, J. Am. Chem. Soc. 71, 758 (1949); Shemyakin, Khokhlov, Dokl. Akad. Nauk SSSR 75, 47 (1950). Synthesis: Woodward, Singh, J. Am. Chem. Soc. 72, 1428 (1950). Biosynthesis: Bu'Lock, Ryan, Proc. Chem. Soc. London 1958, 222; Tanenbaum, Bassett, J. Biol. Chem. 234, 1861 (1959). Inhibition of K+ ion uptake in erythrocytes: Kahn, J. Pharmacol. Exp. Ther. 121, 234 (1957). Physicochemical data: A. E. Pohland et al., Pure Appl. Chem. 54, 2219 (1982). Has carcinogenic activity attributable to a,b-unsaturation together with an external conjugated double bond attached to 4 position of the g-lactone ring: Dickens, Br. Med. Bull. 20, 96 (1964). Toxicity: R. Kinosita, T. Shikata, "On Toxic Moldy Rice" in Mycotoxins in Foodstuffs, G. N. Wogan, Ed. (The M.I.T. Press, Cambridge, 1965) pp 117-119. Review and evaluation of studies of carcinogenic action in laboratory animals: IARC Monographs 10, 205-210 (1976). Review: Ciegler et al., "Patulin, Penicillic Acid and Other Carcinogenic Lactones" in Microbial Toxins vol. VI, A. Ciegler et al., Eds. (Academic Press, New York, 1971) p 409-414.

Goitrin CAS Registry Number: 500-12-9 DL-甲状腺肿素

CAS Name: (5S)-5-Ethenyl-2-oxazolidinethione
Additional Names: 5-vinyl-2-thiooxazolidone; (-)-5-vinyl-2-oxazolidinethione
Percent Composition: C 46.49%, H 5.46%, N 10.84%, O 12.39%, S 24.82%
Literature References: An antithyroid compd isolated from seeds of different species of Brassica, Cruciferae: Astwood et al., J. Biol. Chem. 181, 121 (1949); Greer, J. Am. Chem. Soc. 78, 1260 (1956). Stereochemistry: Kjaer et al., Acta Chem. Scand. 13, 144 (1959). Activity: Langer et al., Endokrinologie 57, 225 (1971).

Altretamine CAS Registry Number: 645-05-6 2,4,6-三(二甲氨基)均三嗪

CAS Name: N,N,N',N',N'',N''-Hexamethyl-1,3,5-triazine-2,4,6-triamine
Additional Names: 2,4,6-tris(dimethylamino)-s-triazine; hemel; hexamethylmelamine; HMMTrademarks: Hexalen (U.S. Bioscience);...
Literature References: An antitumor agent which also acts as a chemosterilant for male houseflies and other insects. Synthesis: A. W. Hofmann, Ber. 18, 2755 (1885); D. W. Kaiser et al., J. Am. Chem. Soc. 73, 2984 (1951); Y. Bessiere-Chretien, H. Serne, Bull. Soc. Chim. Fr. 6, 2039 (1973). Production process: H. von Brachel, H. Kindler, DE 1240870; eidem, US 3424752 (1967, 1969 both to Casella Farbwerke). Chemosterilant effect: S. C. Chang et al., Science 144, 57 (1964); A. De Milo et al., J. Econ. Entomol. 65, 1548 (1972). Chromatographic detn in plasma or serum: A. Hulshoff et al., J. Chromatogr. 181, 363 (1980). Disposition and metabolism in rabbits and humans: M. M. Ames et al., Cancer Res. 39, 5016 (1979). Evaluation in breast cancer: C. J. Fabian et al., Cancer Treat. Rep. 63, 1359 (1979); in ovarian cancer: J. T. Wharton et al., Am. J. Obstet. Gynecol. 133, 833 (1979). Mammalian toxicity study: R. L. Jasper et al., Fed. Proc. 24, 641 (1965). Toxicological studies in dogs and mice: D. C. Thake et al., Gov. Rep. Announce. Index (USA) 79, 92 (1979), C.A. 91, 168372a (1979). In vitro cytotoxicity study: M. D'Incalci et al., Br. J. Cancer 41, 630 (1980).

Gold, Explosive CAS Registry Number: 1332-12-3

Additional Names: Fulminating gold
Literature References: An auric compd of nitrogen. Obtained by the action of ammonia on auric chloride or ammonium chloride on auric oxide: Raschig, Ann. 235, 355 (1886); Weitz, Ann. 410, 117 (1915).

Ribonuclease CAS Registry Number: 9001-99-4 核糖核酸酶 A

Additional Names: RNase
Literature References: An enzyme that digests RNA. First isolated from beef pancreas in 1920. Crystallization from acid extracts of pancreas: Kunitz, J. Gen. Physiol. 24, 15 (1940). Isoln: Kunitz, McDonald, Biochem. Prep. 3, 9 (1953). Bovine pancreatic RNase A is a single-chain peptide of 124 amino acid residues. Primary structure: C. H. W. Hirs et al., J. Biol. Chem. 235, 633 (1960). Amino acid sequence: D. H. Spackman et al., ibid. 648. Pictorial representation of entire structure: Stein, Moore, Sci. Am. 204, no. 2, 81-92 (Feb. 1961). Ribonuclease from plant leaves has slightly different characteristics: Markham, Strominger, Biochem. J. 64, 46P (1956). Can be obtained as a by-product of microbial erythromycin production: JP 63 26938 (1963 to Shionogi). Chemical synthesis of materials possessing partial RNase enzyme activity: Gutte, Merrifield, J. Am. Chem. Soc. 91, 501 (1969); Denkewalter, Hirschmann et al., ibid. 502. Series of articles describing the total synthesis of a protein having the full enzymic activity of bovine pancreatic RNase: N. Fujii, H. Yajima, J. Chem. Soc. Perkin Trans. 1 1981, 789-841. Specifically catalyzes the cleavage of the phosphodiester bond between the 3¢ and 5¢ positions of the ribose moieties in RNA with the formation of oligonucleotides terminating in 2¢,3¢-cyclic phosphate derivs: Roberts et al., Proc. Natl. Acad. Sci. USA 62, 1151 (1969). Reviews: Anfinsen, White, The Enzymes vol. 5, P. D. Boyer et al., Eds. (Academic Press, New York, 2nd ed., 1961) pp 95-122; Richards, Wyckoff, ibid. vol. 4 (3rd ed., 1971) pp 647-806.

Isoleucine CAS Registry Number: 73-32-5 L-异亮氨酸

CAS Name: L-Isoleucine
Additional Names: Ile; I; 2-amino-3-methylvaleric acid; a-amino-b-methylvaleric acid; (2S,3S)-2-amino-3-methylpentanoic acid
Percent Composition: C 54.94%, H 9.99%, N ...
Literature References: An essential amino acid for human development. Isoln from beet-sugar mother liquors: F. Ehrlich, Ber. 37, 1809 (1904). Structure and identification of isomers: idem, Ber. 40, 2538 (1907); J. P. Greenstein et al., J. Biol. Chem. 204, 307 (1953). Early chemistry and biochemistry: Amino Acids and Proteins, D. M. Greenberg, Ed. (Charles C. Thomas, Springfield, IL, 1951) 950 pp., passim; J. P. Greenstein, M. Winitz, Chemistry of the Amino Acids vol 1-3 (John Wiley and Sons, Inc., New York, 1961) pp. 2043-2074, passim. TLC determ in serum from patients with maple sugar urine disease (MSDU): R. J. Allen et al., Clin. Chem. 18, 413 (1972). Metabolism of Ile and isomers in MSDU: U. Wendel et al., Pediatr. Res. 25, 11 (1989); and clinical consequences: T. Mogos et al., Rev. Roum. Med. Interne 32, 57 (1994). Review of biosynthesis: M. Iaccarino et al., Curr. Top. Cell. Regul. 14, 29-73 (1978).