其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Arachidonic Acid CAS Registry Number: 506-32-1 花生四烯酸

CAS Name: (5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic acid
Percent Composition: C 78.90%, H 10.59%, O 10.51%
Literature References: An essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes, q.q.v. Structure: Mowry et al., J. Biol. Chem. 142, 679 (1942); Arcus, Smedley-Maclean, Biochem. J. 37, 1 (1943). Occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and is a constituent of animal phosphatides. Isolation from liver lipids: Brown, J. Biol. Chem. 80, 455 (1928); from beef suprarenal phosphatides: Ault, Brown, ibid. 107, 615 (1934); Shinowara, Brown, ibid. 134, 331 (1940). See also Dolby et al., Biochem. J. 34, 1422 (1940). Synthesis from 2-propargyloxytetrahydropyran and 1-heptyne: Goldberg, Rachlin, US 2934570 (1960 to Hoffmann-La Roche); Rachlin et al., J. Org. Chem. 26, 2688 (1961). Alternate route: Osbond, Wickens, Chem. Ind. (London) 1959, 1288; Ege et al., J. Am. Chem. Soc. 83, 3080 (1961). Reviews: K. S. Markley, Fatty Acids Part I (Interscience, New York, 2nd ed., 1960) pp 164-167, 398-400; T. K. Schaaf, Annu. Rep. Med. Chem. 12, 182-190 (1977); B. B. Weksler, N. Engl. Soc. Allergy Proc. 2, 56-61 (1981); N. A. Nelson et al., Chem. Eng. News 60, 30-44 (Aug. 16, 1982). Series of articles on metabolism, role in inflammation and therapeutic implications: Drugs 33, Suppl. 1, 2-66 (1987).

Linolenic Acid CAS Registry Number: 463-40-1 α-亚麻酸

CAS Name: (Z,Z,Z)-9,12,15-Octadecatrienoic acid
Additional Names: a-linolenic acid
Percent Composition: C 77.65%, H 10.86%, O 11.49%
Literature References: An essential fatty acid. Occurs as the glyceride in most drying oils. Synthesis: Nigam, Weedon, J. Chem. Soc. 1956, 4049; Osbond, Wickens, Chem. Ind. (London) 1959, 1288. Biosynthetic studies: C. G. Kannangara et al., Biochem. Biophys. Res. Commun. 52, 648 (1973); B. S. Jacobson et al., ibid. 1190; C. J. Bedord et al., Arch. Biochem. Biophys. 185, 15 (1978). Effects on lipid metabolism in rat tissue: M. L. Garg et al., Lipids 23, 847 (1988). Review of dietary linolenic acid in mammals: J. Tinoco et al., ibid. 14, 166-171 (1979); in man: N. Zöllner, Prog. Lipid Res. 25, 177-180 (1986).

Coumestrol CAS Registry Number: 479-13-0 拟雌内酯

CAS Name: 3,9-Dihydroxy-6H-benzofuro[3,2-c][1]benzopyran-6-one
Additional Names: 2-(2,4-dihydroxyphenyl)-6-hydroxy-3-benzofurancarboxylic acid d-lactone; 7',6-dihydroxycoumarino(3',4',3,2)couma...
Literature References: An estrogenic factor occurring naturally in forage crops, esp in ladino clover (Trifolium repens L.), strawberry clover (T. fragiferum L.) and alfalfa (Medicago sativa L., Leguminosae). Isoln: Bickoff et al., J. Agric. Food Chem. 6, 536 (1958); Bickoff, Booth, US 2890116 (1959 to U.S.A.). Structure: Bickoff et al., J. Am. Chem. Soc. 80, 3969 (1958). Synthesis: Emerson, Bickoff, ibid. 4381; US 2884427 (1959 to U.S.A.); Jurd, Tetrahedron Lett. 1963, 1151; Kappe, Brandner, Z. Naturforsch. 29B, 292 (1974). Biosynthesis: Grisebach, Barz, Chem. Ind. (London) 1963, 690.

Gitalin CAS Registry Number: 1405-76-1 无定形吉他林

Trademarks: Gitaligin (Schering)
Literature References: An extract of Digitalis purpurea L., Scrophulariaceae, once believed to be a single amorphous compd, is a stable, relatively constant mixture of digitoxin, gitoxin, q.q.v., and gitaloxin (16-formylgitoxin, Cristaloxine) with smaller amounts of several other glycosides and genins, together with minute amounts of other substances. Review of prepn and composition: Mitchell, Am. J. Pharm. 136, 71 (1964).

Homogentisic Acid CAS Registry Number: 451-13-8 尿黑酸,高龙胆酸

CAS Name: 2,5-Dihydroxybenzeneacetic acid
Additional Names: 2,5-dihydroxyphenylacetic acid; 2,5-dihydroxy-a-toluic acid
Percent Composition: C 57.14%, H 4.80%, O 38.06%
Literature References: An important intermediate in metabolism of tyrosine and phenylalanine, q.q.v.. Occurs in plants and in the urine of alkaptonurics: Garrod, Inborn Errors of Metabolism (Oxford Medical Publications, London, 1923, and later). Isoln from alkaptonuric urine: Mörner, Z. Physiol. Chem. 117, 85 (1921). Synthesis from 2,5-dihydroxymandelic acid or from 2,5-dihydroxyphenylglyoxylic acid by boiling with fuming HI: Neubauer, Flatow, ibid. 52, 395 (1907). Alternate syntheses: L. DeForrest Abbott, J. D. Smith, J. Biol. Chem. 179, 365 (1949); S. B. Bostock, A. H. Renfrew, Synthesis 1978, 66; J. L. Bloomer, K. M. Damodaran, ibid. 1980, 111. Biosynthesis from tyrosine: Davies et al., J. Chem. Soc. 1964, 3126. Metabolic studies: W. E. Knox, M. LeMay-Knox, Biochem. J. 49, 686 (1951); B. N. LaDu, V. G. Zannoni, J. Biol. Chem. 217, 777 (1955).

Enterogastrone CAS Registry Number: 9007-67-4

Additional Names: Anthelone E; enteroanthelone
Trademarks: Duosan; Ileogastrone
Literature References: An inhibitor of gastric secretion, apparently different from urogastrone. Obtained from extracts of the intestinal mucosa of mammals: Gray, Ivy, Cold Spring Harbor Symp. Quant. Biol. 5, 405 (1937); Ivy, Greengard, US 2477541 (1949 to Research Corp.). Comparison with urogastrone: Friedman, Vitam. Horm. 9, 313 (1951); Gregory, J. Physiol. 129, 528 (1955).

Mopidamol CAS Registry Number: 13665-88-8 莫哌达醇

CAS Name: 2,2',2'',2'''-[[4-(1-Piperidinyl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo]tetrakisethanol
Additional Names: 2,2',2'',2'''-[(4-piperidinopyrimido[5,4-d]-pyrimidine-2,6-diyl)dinitri...
Literature References: An inhibitor of platelet aggregation with antimetastatic properties. Prepn: GB 1051218 corresp to J. Roch, H. Scheffler, US 3322755 (1966, 1967 both to Boehringer, Ing.). Effect on tumor cell metastasis: J. L. Ambrus et al., J. Med. 9, 183 (1978); on inhibition of adenosine uptake into platelets: J. P. Lips et al., Biochem. Pharmacol. 29, 43 (1980). Therapeutic use: R. L. Clark, Cancer 43, 790 (1979); I. L. Bonta et al., Agents Actions Suppl. 4, 278 (1979).

Metyrosine CAS Registry Number: 672-87-7 α-甲基-L-酪氨酸

CAS Name: a-Methyl-L-tyrosine
Additional Names: a-methyl-p-tyrosine; a-methyltyrosine; 4-hydroxy-a-methylphenylalanine; a-methyl-3-(p-hydroxyphenyl)alanine; metirosine; L-a-MT; a-MPTTrademarks:...
Literature References: An inhibitor of the first and rate-limiting reaction in catecholamine biosynthesis, the hydroxylation of tyrosine to dopa. Prepn: NL 6607757 (1966 to Merck Co.), C.A. 67, 91108p (1967). Prepn of DL-form: Stein et al., J. Am. Chem. Soc. 77, 700 (1955); Potts, J. Chem. Soc. 1955, 1632; Pfister, Stein, US 2868818 (1959 to Merck Co.); Saari, J. Org. Chem. 32, 4074 (1967). Metabolism and biochemical and pharmacologic effects in man: Engelman et al., J. Clin. Invest. 47, 568, 577 (1968). Review of pharmacology and clinical use: R. N. Brogden et al., Drugs 21, 81-89 (1981).

Porphobilinogen CAS Registry Number: 487-90-1 胆色素原

CAS Name: 5-(Aminomethyl)-4-(carboxymethyl)-1H-pyrrole-3-propanoic acid
Additional Names: 2-aminomethylpyrrol-3-acetic acid 4-propionic acid
Percent Composition: C 53.09%, H 6.24%, N 12.38%,...
Literature References: An intermediate in the biosynthesis of heme, q.v., found in the urine of patients with acute porphyria: Westall, Nature 170, 614 (1952). Isoln and structure: Cookson, Rimington, Biochem. J. 57, 476 (1954). Synthesis: Jackson, MacDonald, Can. J. Chem. 35, 715 (1957). Chemistry of conversion into porphyrins: Mathewson, Corwin, J. Am. Chem. Soc. 83, 135 (1961).

Glyceraldehyde 3-Phosphate CAS Registry Number: 142-10-9 甘油醛-3-磷酸盐

CAS Name: 2-Hydroxy-3-(phosphonooxy)propanal
Additional Names: 3-phosphoglyceraldehyde
Percent Composition: C 21.19%, H 4.15%, O 56.45%, P 18.21%
Literature References: An intermediate product of carbohydrate metabolism. Prepn of DL-form by enzymatic route: Meyerhof, Junowicz-Kocholaty, J. Biol. Chem. 149, 71 (1943); by reductive cleavage of glyceraldehyde 1-benzyl ether 3-phosphoric acid: Fischer, Baer, Ber. 65, 337, 1040 (1932); by hydrolysis of dimeric glyceraldehyde 1,3-diphosphoric acid: Baer, Fischer, J. Biol. Chem. 150, 213 (1943); by hydrolysis of dimeric glyceraldehyde 1-bromide 3-phosphoric acid: ibid. 223. See also Baer in Biochem. Prep. 1, 50 (1949). Prepn of D-form by enzymatic route: Meyerhof, Junowicz-Kocholaty, loc. cit.; by synthetic route: Ballou, Fischer, J. Am. Chem. Soc. 77, 3329 (1955).