其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
备注: 根据相关法律法规, 本站点不显示有法律约束管制的产品, 如有遗漏, 请自行鉴别,或提交我们及时更新撤除.
如有产品相关项目调研推广服务, 请致函联系我们

客户展示

其它产品项目整合

Iodized Oil CAS Registry Number: 8001-40-9 花生碘化油

Trademarks: Lipiodol (Guerbet)
Literature References: An iodine addition product of vegetable oils, contg 38-42% organically combined iodine.

Povidone-Iodine CAS Registry Number: 25655-41-8 聚维酮碘

CAS Name: 1-Ethenyl-2-pyrrolidinone homopolymer compd with iodine
Additional Names: 1-vinyl-2-pyrrolidinone polymers, iodine complex; iodine-polyvinylpyrrolidone complex; polyvinylpyrrolidone-i...
Literature References: An iodophor, q.v., prepd by Beller, Hosmer, US 2706701; Hosmer, US 2826532; Siggia, US 2900305 (1955, 1958, and 1959, all to GAF). Prepn, history and use: Shelanski, Shelanski, J. Int. Coll. Surg. 25, 727 (1956).

Pseudocodeine CAS Registry Number: 466-96-6

CAS Name: (5a,8b)-6,7-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-8-ol
Additional Names: y-codeine; neoisocodeine
Percent Composition: C 72.22%, H 7.07%, N 4.68%, O 16.03%
Literature References: An isomer of codeine. Review and bibliography: K. W. Bentley, The Chemistry of the Morphine Alkaloids (Oxford, 1954).

Viquidil CAS Registry Number: 84-55-9 1-丙酮, 3-[(3R,4R)-3-乙烯基-4-哌啶基]-1-(6-甲氧基-4-喹啉基)-

CAS Name: (3R-cis)-3-(3-Ethenyl-4-piperidinyl)-1-(6-methoxy-4-quinolinyl)-1-propanone
Additional Names: quinicine; 1-(6-methoxy-4-quinolyl)-3-(3-vinyl-4-piperidyl)-1-propanone; chinicine; mequi...
Literature References: An isomer of quinine; occurs naturally as the d-form. Present in small quantities in cinchona barks; formed by heating quinine with glycerol at 180°: Howard, J. Chem. Soc. 24, 61 (1871); 25, 101 (1872); Miller, Rohde, Ber. 33, 3214 (1900); Howard, Chick, Pharm. J. 99, 143 (1917). Conversion to quinine: Rabe, Kindler, Ber. 51, 466 (1918). Partial synthesis: Prostenik, Prelog, Helv. Chim. Acta 26, 1965 (1943). Total synthesis: Woodward, Doering, J. Am. Chem. Soc. 66, 849 (1944); 67, 860 (1945); US 2500444 (1950 to Polaroid); Grethe et al., Helv. Chim. Acta 56, 1485 (1973). Review of synthesis, chemistry and pharmacology: Quevauviller et al., Ann. Pharm. Fr. 24, 39 (1966). Series of articles on pharmacology and metabolism: Arzneim.-Forsch. 22, 1334-1346 (1972).

Geraniol CAS Registry Number: 106-24-1 香叶醇; (E)-3,7-二甲基-2,6-辛二烯-1-醇

CAS Name: (E)-3,7-Dimethyl-2,6-octadien-1-ol
Additional Names: trans-3,7-dimethyl-2,6-octadien-8-ol; lemonol
Percent Composition: C 77.87%, H 11.76%, O 10.37%
Literature References: An olefinic terpene alcohol constituting the chief part of oil of rose and oil of palmarosa; also found in many other essential oils such as citronella, lemon grass, etc. Isomeric with linalool. Isoln: Jacobsen, Ann. 157, 234 (1871). Structure: Verley, Bull. Soc. Chim. Fr. 25, 68 (1919); J. L. Simonsen, The Terpenes vol. I (University Press, Cambridge, 2nd ed., 1947) pp 40-52. Stereochemistry: Burrell et al., Proc. Chem. Soc. London 1959, 263; Bates et al., J. Org. Chem. 28, 1086 (1963). Synthesis: Burrell et al., J. Chem. Soc. C 1966, 2144; K. Takabe et al., Chem. Lett. 1977, 1025; K. K. Mathew et al., Indian J. Chem. B20, 340 (1981).

Sodium Cacodylate CAS Registry Number: 124-65-2 甲胂酸钠

CAS Name: [(Dimethylarsino)oxy]sodium As-oxide
Additional Names: sodium dimethylarsonate
Trademarks: Arsecodile; Arsicodile; Arsycodile; Rad-e-cate (Vineland); Silvisar
Percent Compositio...
Literature References: An organic compd of arsenic yielding inorganic, trivalent arsenic in the body (is excreted partly unchanged, also yields dimethylarsine oxide). Prepd by the distillation of a mixture of arsenic trioxide and potassium acetate which yields Cadet's liquid, contg mostly dimethylarsine oxide. This is oxidized with mercuric oxide yielding crystals of cacodylic acid which is neutralized with Na2CO3 or NaOH: Cadet de Gassicourt, Mem. savants étrangers 3, 633 (1760); Valeur, Gaillot, Compt. Rend. 185, 956 (1927). Use in treatment of psoriasis: S. I. Dawes, H. C. Jackson, J. Am. Med. Assoc. 48, 2020 (1903). Metabolism and excretion: A. Heffter, Arch. Exp. Pathol. Pharmakol. 46, 230 (1901). Use as herbicide: M. A. Sprague, US 3056663 (1962 to Ansul). Possible use in radiation dosimetry: H. S. Levinson, E. B. Garber, Nature 207, 751 (1965). Review of toxicology and human exposure: Toxicological Profile for Arsenic (PB2000-108021, 2000) 468 pp.

Ascaridole CAS Registry Number: 512-85-6 阿斯利多

CAS Name: 1-Methyl-4-(1-methylethyl)-2,3-dioxabicyclo[2.2.2]oct-5-ene
Additional Names: 1,4-peroxido-p-menthene-2
Percent Composition: C 71.39%, H 9.59%, O 19.02%
Literature References: An organic peroxide which constitutes 60-80% of oil of chenopodium. Synthesis from a-terpinene by treatment with oxygen, chlorophyll, and light: Schenck, Ziegler, Naturwissenschaften 1944, 157. Purification: Beckett et al., J. Pharm. Pharmacol. 7, 55 (1955). Isoln from Chenopodium ambrosioides L.: E. Okuyama et al., Chem. Pharm. Bull. 41, 1309 (1993). Review of use as anthelmintic: M. M. Kliks, Soc. Sci. Med. 21, 879-886 (1985).

Sobrerol CAS Registry Number: 498-71-5 1-对孟烯-6,8-二醇

CAS Name: 5-Hydroxy-a,a,4-trimethyl-3-cyclohexene-1-methanol
Additional Names: p-menth-6-ene-2,8-diol; 6,8-carvomenthenediol; 1-p-menthene-6,8-diol; pinol hydrate
Percent Composition: C 70.5...
Literature References: An oxidation product of oil of turpentine formed by the autooxidation of a-pinene, q.v., in the presence of water and especially in sunlight. First obtained by Margueron in 1797. Confused with terpin hydrate, q.v., until fully characterized by Sobrero in 1851. The naturally occurring form is the trans-form. For a review of early structure and prepn work, see J. L. Simonsen, The Terpenes vol. II (University Press, Cambridge, 2nd ed., 1949) pp 137-138. Summary of general methods of prepn: Lombard, Heywang, Bull. Soc. Chim. Fr. 1954, 1210. Prepn of dl-trans-form: Ward, J. Am. Chem. Soc. 60, 325 (1938); Schenck et al., Ann. 584, 177 (1953); Moore et al., J. Am. Chem. Soc. 78, 1173 (1956); Brook, Wright, J. Org. Chem. 22, 1314 (1957); of l-trans-form: Klein, US 2815378 (1958 to Glidden). Prepn of cis- and trans-forms and analysis of stereochemistry: Blumann, Wood, J. Chem. Soc. 1952, 4420; H. Schmidt, Ber. 86, 1437 (1953). Pharmacology and chemistry of dl-trans-form: GB 1176817; C. Corvi-Mora, US 3592908 (1970, 1971 to Camillo Corvi); V. Dalla Valle, Boll. Chim. Farm. 109, 761 (1970). Clinical evaluation: C. F. Marchioni, G. Monzali, Clin. Ter. 60, 135 (1972). Activity on mucociliary transport: P. Braga, Clin. Trials J. 18, 30 (1981). Pharmacokinetics: P. C. Braga et al., Eur. J. Clin. Pharmacol. 24, 209 (1983). Metabolism: P. Ventura et al., Xenobiotica 13, 139 (1983); eidem, ibid. 15, 317 (1985). GLC determn in human plasma: U. A. Shulka, J. Chromatogr. 308, 189 (1984).

Substance P CAS Registry Number: 11035-08-8

Additional Names: SP
Percent Composition: C 56.15%, H 7.33%, N 18.71%, O 15.43%, S 2.38%
Literature References: An undecapeptide belonging to a group of proteins named tachykinins characterized by contractile action on extravascular smooth muscle. Discovered by von Euler and Gaddum, J. Physiol. 72, 74 (1931). Present in the brain of all vertebrates including man, in spinal ganglia, and in the intestines, esp the duodenum and jejunum. Isoln from cattle brain: Zuber, Jaques, Angew. Chem. Int. Ed. 1, 160 (1962); from horse intestine: Studer et al., Helv. Chim. Acta 56, 860 (1973). Purification from bovine hypothalami and amino acid composition: N. N. Chang, S. E. Leeman, J. Biol. Chem. 245, 4784 (1970). Amino acid sequence and solid-phase synthesis: Chang et al., Nature New Biol. 232, 86 (1971); Tregear et al., ibid. 87; G. H. Fisher et al., J. Med. Chem. 17, 843 (1974). Additional syntheses: Yajima, Kitigawa, Chem. Pharm. Bull. 21, 682 (1973); Bayer, Mutter, Ber. 107, 1344 (1974); K. Neubert et al., Pharmazie 36, 10 (1981); A. Fournier et al., J. Med. Chem. 25, 64 (1981). Substance P acts as a vasodilator, a depressant, stimulates salivation and produces increased capillary permeability. It is also capable of producing both analgesia and hyperalgesia in animals, depending on dose and pain responsiveness of the animal, see R. C. A. Frederickson et al., Science 199, 1359 (1978); P. Oehme et al., ibid. 208, 305 (1980); role in sensory transmission and pain perception: T. M. Jessell, Adv. Biochem. Psychopharmacol. 28, 189 (1981). Mechanism of action studies: Stern et al., Arch. Pharmacol. 281, 233 (1974); B. G. Livett et al., Nature 278, 256 (1979). Reviews: Haefeli, Huelimann, Experientia 18, 297 (1962); Lembeck, Zetler in International Encyclopedia of Pharmacology and Therapeutics sect. 72, vol. 1, J. M. Walker, Ed. (Pergamon Press, New York, 1971) pp 29-71; J. L. Barker, Physiol. Rev. 56, 435 (1976); D. R. Brown, R. J. Miller, Annu. Rep. Med. Chem. 17, 271-280 (1982). Books: U.S. Von Euler, B. Pernow, Eds., Substance P (Raven Press, New York, 1977) 360 pp; Substance P vol. 2, P. Skrabanek, D. Powell, Eds. (Eden Press, Quebec, 1980) 175 pp; Substance P in The Nervous System: Ciba Foundation Symposium 91, R. Porter, M. O'Connor, Eds. (Pitman, London, 1982) 350 pp.

Furazabol CAS Registry Number: 1239-29-8 夫拉扎勃

CAS Name: (5a,17b)-17-Methylandrostano[2,3-c][1,2,5]oxadiazol-17-ol
Additional Names: 17b-hydroxy-17a-methyl-5a-androstano[2,3-c]furazan; androfurazanol; furazalonTrademarks: Miotolon (Daiichi)...
Literature References: Anabolic steroid with hypocholesterolemic properties. Prepn: G. Ohta et al., BE 645743; eidem, US 3245988 (1964, 1966 both to Daiichi Seiyaku); Shimizu et al., Chem. Pharm. Bull. 13, 895 (1965); Ohta et al., ibid. 1445. Pharmacological studies: Kasahara et al., ibid. 13, 1460 (1965); 16, 1456, 1460 (1968). Toxicity: eidem, ibid. 14, 285 (1966). Metabolic studies: Takegoshi et al., ibid. 20, 1243 (1972). GC-MS determn in urine: T. Kim et al., J. Chromatogr. B 687, 79 (1996).