Altretamine CAS Registry Number: 645-05-6 2,4,6-三(二甲氨基)均三嗪

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Literature References: An antitumor agent which also acts as a chemosterilant for male houseflies and other insects. Synthesis: A. W. Hofmann, Ber. 18, 2755 (1885); D. W. Kaiser et al., J. Am. Chem. Soc. 73, 2984 (1951); Y. Bessiere-Chretien, H. Serne, Bull. Soc. Chim. Fr. 6, 2039 (1973). Production process: H. von Brachel, H. Kindler, DE 1240870; eidem, US 3424752 (1967, 1969 both to Casella Farbwerke). Chemosterilant effect: S. C. Chang et al., Science 144, 57 (1964); A. De Milo et al., J. Econ. Entomol. 65, 1548 (1972). Chromatographic detn in plasma or serum: A. Hulshoff et al., J. Chromatogr. 181, 363 (1980). Disposition and metabolism in rabbits and humans: M. M. Ames et al., Cancer Res. 39, 5016 (1979). Evaluation in breast cancer: C. J. Fabian et al., Cancer Treat. Rep. 63, 1359 (1979); in ovarian cancer: J. T. Wharton et al., Am. J. Obstet. Gynecol. 133, 833 (1979). Mammalian toxicity study: R. L. Jasper et al., Fed. Proc. 24, 641 (1965). Toxicological studies in dogs and mice: D. C. Thake et al., Gov. Rep. Announce. Index (USA) 79, 92 (1979), C.A. 91, 168372a (1979). In vitro cytotoxicity study: M. D'Incalci et al., Br. J. Cancer 41, 630 (1980).