其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Chalcone CAS Registry Number: 94-41-7 苯亚甲基苯乙酮

CAS Name: 1,3-Diphenyl-2-propen-1-one
Additional Names: chalkone; benzylideneacetophenone; benzalacetophenone; phenyl styryl ketone
Percent Composition: C 86.51%, H 5.81%, O 7.68%
Literature References: Prepd by the action of NaOH on an alcoholic soln of benzaldehyde and acetophenone: E. P. Kohler, H. M. Chadwell, Org. Synth. coll. vol. I, 78 (1941).

p-Tolylsulfonylmethylnitrosamide CAS Registry Number: 80-11-5 N-甲基-N-亚硝基对甲苯磺酰胺

CAS Name: N,4-Dimethyl-N-nitrosobenzenesulfonamide
Additional Names: N-methyl-N-nitroso-p-toluenesulfonamide
Trademarks: Diazald (Aldrich)
Percent Composition: C 44.85%, H 4.70%, N 13.08%...
Literature References: Prepd by the action of nitrous acid on p-tolylsulfonylmethylamide: DE 224388 (1910 to Bayer); Frdl. 10, 1216; Chem. Zentralbl. 1910, II, 609; Takizawa, J. Pharm. Soc. Jpn. 70, 490 (1950); de Boer, Backer, Rec. Trav. Chim. 73, 229 (1954); Org. Synth. 34, 96 (1954).

N-Acetylsulfanilic Acid CAS Registry Number: 121-62-0 4-乙酰氨基苯磺酸

CAS Name: 4-(Acetylamino)benzenesulfonic acid
Additional Names: N-p-acetylanilinosulfonic acid; acetanilidsulfonic acid; 4-acetamidobenzenesulfonic acid
Percent Composition: C 44.64%, H 4.21...
Literature References: Prepd by the action of oleum or sulfuric acid on acetanilide in acetic anhydride: Junghahn, Neumann, Ber. 33, 1366 (1900); Söll, Stutzer, Ber. 42, 4539 (1909).

Glycidol CAS Registry Number: 556-52-5 缩水甘油

CAS Name: Oxiranemethanol
Additional Names: 2,3-epoxy-1-propanol; 3-hydroxypropylene oxide
Percent Composition: C 48.64%, H 8.16%, O 43.19%
Literature References: Prepd by the action of perbenzoic acid on allyl alc: Prileshajew, Ber. 42, 4813 (1909); from glycerol-1-monochlorohydrin by the action of KOH in alc, or by the action of sodium in ether: Rider, Hill, J. Am. Chem. Soc. 52, 1521 (1930). L-form prepd from L-1-(p-toluenesulfonyl)glycerol: Sowden, Fischer, ibid. 64, 1291 (1942). Acute toxicity data: E. D. Thompson, R. A. Hiles, Food Cosmet. Toxicol. 19, 347 (1981); E. D. Thompson, D. P. Gibson, Food Chem. Toxicol. 22, 665 (1984).

Triphenylcarbinol CAS Registry Number: 76-84-6 三苯基甲醇

CAS Name: Triphenylmethanol
Additional Names: tritanol
Percent Composition: C 87.66%, H 6.19%, O 6.15%
Literature References: Prepd by the action of phenylmagnesium bromide on benzophenone: Acree, Ber. 37, 2755 (1904); Peters et al., J. Am. Chem. Soc. 47, 452 (1925); Dubsky, Jacot-Guillarmod, Helv. Chim. Acta 53, 1965 (1970); by the action of potassium permanganate on triphenylfluoro- or triphenylchloromethane: Blicke, J. Am. Chem. Soc. 46, 1518 (1924). Convenient lab prepn from methyl benzoate and phenylmagnesium bromide: L. F. Fieser, Experiments in Organic Chemistry (Boston, 3rd ed., 1955) p 77.

Guaiacol Carbonate CAS Registry Number: 553-17-3 碳酸愈创木酚酯

Additional Names: Carbonic acid bis(2-methoxyphenyl) ester; guaiacol carbonic acid neutral ester; carbonic acid guaiacol ether
Trademarks: Duotal
Percent Composition: C 65.69%, H 5.14%, O 29...
Literature References: Prepd by the action of phosgene on a concd soln of guaiacol in aq NaOH: DE 58129 (to Bayer); S. P. Schotz, Synthetic Organic Compounds (London, 1925) p 137; J. Schwyzer, Die Fabrikation pharmazeutischer und chemisch-technischer Produkte (Berlin, 1931) p 212; H. P. Kaufmann, Arzneimittel-Synthese (Springer-Verlag, 1953) p 607.

Isonicotinic Acid Diethylamide CAS Registry Number: 530-40-5 N,N-二乙基异烟酰胺

CAS Name: N,N-Diethylisonicotinamide
Additional Names: pyridine-4-carboxylic acid diethylamide
Percent Composition: C 67.39%, H 7.92%, N 15.72%, O 8.98%
Literature References: Prepd by the action of phosphorus oxychloride upon a mixture of isonicotinic acid and diethylamine: Carrara, US 2858317 (1958 to Lepetit).

Aniline Mustard CAS Registry Number: 553-27-5 N,N-双(2-氯乙基)苯胺

CAS Name: N,N-Bis(2-chloroethyl)benzenamine
Additional Names: N,N-bis(2-chloroethyl)aniline; phenylbis[2-chloroethylamine]; b,b'-dichlorodiethylaniline
Percent Composition: C 55.06%, H 6.01%...
Literature References: Prepd by the action of phosphorus pentachloride on N,N-bis-[2-hydroxyethyl]aniline (phenyldiethanolamine): Robinson, Watt, J. Chem. Soc. 1934, 1538; Korshak, Strepikheev, J. Gen. Chem. USSR 14, 312 (1944).

Thioformamide CAS Registry Number: 115-08-2 硫代甲酰胺

CAS Name: Methanethioamide
Percent Composition: C 19.65%, H 4.95%, N 22.92%, S 52.47%
Literature References: Prepd by the action of phosphorus pentasulfide on formamide: Willstätter, Wirth, Ber. 42, 1911 (1909). Synthesis: Erlenmeyer, Menzi, Helv. Chim. Acta 31, 2071 (1948); Schmitz, US 2682558 (1954 to du Pont); R. Tull, L. M. Weinstock, Angew. Chem. Int. Ed. 8, 278 (1969). Spectroscopic studies: R. Sugisaki et al., J. Mol. Spectrosc. 49, 241 (1974); R. H. Judge et al., Can. J. Chem. 65, 2100 (1987). Use in synthesis of thiazoles: T. J. Cousineau, J. A. Secrist III, J. Org. Chem. 44, 4351 (1979); H. Fukatsu et al., Heterocycles 29, 1517 (1989).

Entprol CAS Registry Number: 102-60-3 四羟丙基乙二胺

CAS Name: 1,1',1'',1'''-(1,2-Ethanediyldinitrilo)tetrakis[2-propanol]
Additional Names: 1,1',1'',1'''-(ethylenedinitrilo)tetra-2-propanol; N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine
...
Literature References: Prepd by the action of propylene oxide on ethylenediamine: Lundsted, Schulz, US 2697118 (1954 to Wyandotte).