其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Camphotamide CAS Registry Number: 4876-45-3 樟吡他胺

CAS Name: 3-[(Diethylamino)carbonyl]-1-methylpyridinium salt with 4,7,7-trimethyl-3-oxobicyclo[2.2.1]heptane-2-sulfonic acid (1:1)
Additional Names: 3-(diethylcarbamoyl)-1-methylpyridinium 2-ox...
Literature References: Prepd by the condensation of equimolar amounts of camphorsulfonic acid and N-methylnikethamide: Lab. Lematte et Boinot in P. Lebeau, M. Janot, Traité de Pharmacie Chimique vol. 4, (Paris 1955-56) p 2471; by reacting nicotinic acid with methyl camphorsulfonate and treating with diethylamine: FR 812032 (1937 to Soc. Franc. Recherches Biochim.), C.A. 32, 1052 (1938).

Propylthiouracil CAS Registry Number: 51-52-5 丙硫氧嘧啶

CAS Name: 2,3-Dihydro-6-propyl-2-thioxo-4(1H)pyrimidinone
Additional Names: 6-propyl-2-thiouracil; 2-thio-4-oxo-6-propyl-1,3-pyrimidine; 2-thio-6-propyl-1,3-pyrimidin-4-one
Trademarks: Propa...
Literature References: Prepd by the condensation of ethyl b-oxocaproate with thiourea: Anderson et al., J. Am. Chem. Soc. 67, 2197 (1945). Comprehensive description: H. Y. Aboul-Enein, Anal. Profiles Drug Subs. 6, 457-486 (1977). Review of pharmacology and clinical experience: D. S. Cooper et al., N. Engl. J. Med. 311, 1353-1362 (1984).

Arsenamide CAS Registry Number: 531-72-6 4-[二(羧基甲硫基)胂基]苯甲酰胺

CAS Name: 2,2'-[[[4-(Aminocarbonyl)phenyl]arsinidene]bis(thio)]bisacetic acid
Additional Names: [[(p-carbamoylphenyl)arsylene]dithio]diacetic acid; bis[carboxymethylmercapto](p-carbamylphenyl)-...
Literature References: Prepd by the condensation of p-arsenosobenzamide and thioglycolic acid: Gough, King J. Chem. Soc. 1930, 669; Maren, J. Am. Chem. Soc. 68, 1864 (1946).

Sulfobromophthalein Sodium CAS Registry Number: 71-67-0 磺溴酚酞钠盐水合物

CAS Name: 3,3'-(4,5,6,7-Tetrabromo-3-oxo-1(3H)-isobenzofuranylidene)bis[6-hydroxybenzenesulfonic acid] disodium salt
Additional Names: disodium phenoltetrabromophthalein sulfonate; bromosulfoph...
Literature References: Prepd by the condensation of phenol and tetrabromophthalic acid or its anhydride, followed by sulfonation and conversion to the disodium salt. Pharmacology and use as liver function test: S. M. Rosenthal, E. C. White, J. Pharmacol. 24, 265 (1924); W. Häcki et al., J. Lab. Clin. Med. 88, 1019 (1976).

Phentetiothalein Sodium CAS Registry Number: 18265-54-8 2,3,4,5-四碘-6-[(4-羟基苯基)(4-羰基环己-2,5-二烯-1-亚基)甲基]苯酸二钠

CAS Name: 4,5,6,7-Tetraiodophenolphthalein sodium
Additional Names: 3,3-bis(4-hydroxyphenyl)-4,5,6,7-tetraiodo-1(3H)-isobenzofuranone disodium salt; 3,4,5,6-tetraiodophenolphthalein disodium sa...
Literature References: Prepd by the condensation of phenol and tetraiodophthalic acid or its anhydride: Orndorff, Black, Am. Chem. J. 41, 349 (1909); Zalkind, Belikova, Zh. Prikl. Khim. 8, 1210 (1935). Isomeric with iodophthalein sodium, q.v.

Benzocaine CAS Registry Number: 94-09-7 对氨基苯甲酸乙酯

CAS Name: 4-Aminobenzoic acid ethyl ester
Additional Names: ethyl aminobenzoate
Trademarks: Americaine (Medeva); Anaesthesin (Ritsert); Flavamed (Berlin-Chemie); Subcutin (Ritsert)
Percen...
Literature References: Prepd by the esterification of p-aminobenzoic acid: Salkowski, Ber. 28, 1921 (1895); Vorländer, Meyer, Ann. 320, 135 (1902); by the reduction of ethyl p-nitrobenzoate: Limpricht, ibid. 303, 278 (1898); R. Adams, F. L. Cohen, Org. Synth. coll. vol. I, 240 (2nd ed., 1941). In industrial practice the reducing agent is usually iron and water in the presence of a little acid. Comprehensive description: S. L. Ali, Anal. Profiles Drug Subs. 12, 73-104 (1983).

Butamirate CAS Registry Number: 18109-80-3 布他米酯

CAS Name: a-Ethylbenzeneacetic acid 2-[2-(diethylamino)ethoxy]ethyl ester
Additional Names: 2-phenylbutyric acid 2-[2-(diethylamino)ethoxy]ethyl ester; 2-[2-(diethylamino)ethoxy]ethyl 2-phenylb...
Literature References: Prepd by the esterification of phenylethylacetyl chloride with diethylaminoethoxyethanol: DE 1151515; Heusser, US 3349114 (1963, 1967, both to Hommel A.G.).

Benzophenone CAS Registry Number: 119-61-9 二苯甲酮

CAS Name: Diphenylmethanone
Additional Names: diphenyl ketone; benzoylbenzene
Percent Composition: C 85.69%, H 5.53%, O 8.78%
Literature References: Prepd by the Friedel-Crafts ketone synthesis from benzene and benzoyl chloride in the presence of AlCl3: Marvel, Sperry, Org. Synth. coll. vol. I (Wiley, New York, 2nd ed., 1941) p 95. By decarboxylation of o-benzoylbenzoic acid in the presence of copper catalyst: L. F. Fieser, Organic Experiments (D. C. Heath Co., Boston, 1964) pp 201-203.

Carbon Tetraiodide CAS Registry Number: 507-25-5 四碘甲烷

CAS Name: Tetraiodomethane
Percent Composition: C 2.31%, I 97.69%
Literature References: Prepd by the interaction of carbon tetrachloride and aluminum or calcium iodide: Gustavson, Ann. 172, 173 (1874); boron iodide: Moissan, C.R. Hebd. Seances Acad. Sci. 113, 19 (1891); lithium or calcium iodide: Lantenois, ibid. 156, 1385 (1913); ethyl iodide in the presence of aluminum chloride: Walker, J. Chem. Soc. 85, 1090 (1904); McArthur, Simons, Inorg. Synth. 3, 37 (1950).

Tetrasulfur Tetranitride CAS Registry Number: 28950-34-7 1,3,5,7,2,4,6,8-四硫杂四氮杂环辛四烯

Additional Names: Schwefelstickstoff
Percent Composition: N 30.40%, S 69.60%
Literature References: Prepd by the interaction of disulfur dichloride and ammonia: Becke-Goehring, Inorg. Synth. 6, 124 (1960).