其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Noprylsulfamide CAS Registry Number: 576-97-6

CAS Name: 1-[[4-(Aminosulfonyl)phenyl]amino]-3-phenyl-1,3-propanedisulfonic acid disodium salt
Additional Names: 1-phenyl-3-p-sulfamoylanilino-1,3-propanedisulfonic acid disodium salt; N4-(diso...
Literature References: Prepd by the action of sodium bisulfite on N4-cinnamylidenesulfanilamide (prepd from cinnamic aldehyde and sulfanilamide): Despois, US 2262544 (1941 to Rhône-Poulenc).

Dibenzoylmethane CAS Registry Number: 120-46-7 二苯甲酰甲烷

CAS Name: 1,3-Diphenyl-1,3-propanedione
Additional Names: phenyl-a-hydroxystyryl ketone; w-benzoylacetophenone; phenyl phenacyl ketone; g-hydroxychalkone
Percent Composition: C 80.34%, H 5.3...
Literature References: Prepd by the action of sodium methylate on benzylideneacetophenone dibromide: Allen et al., Org. Synth. coll. vol. I (2nd ed., 1941) p 205.

Diazoacetic Ester CAS Registry Number: 623-73-4 重氮乙酸乙酯

Additional Names: Ethyl diazoacetate; ethyl diazoethanoate
Percent Composition: C 42.11%, H 5.30%, N 24.55%, O 28.04%
Literature References: Prepd by the action of sodium nitrite on glycine ethyl ester hydrochloride: Curtius J. Prakt. Chem. [2] 38, 396 (1888); Silberrad, J. Chem. Soc. 81, 600 (1902); Womack, Nelson, Org. Synth. 24, 56 (1944).

Thioglycolic Acid CAS Registry Number: 68-11-1 硫代乙醇酸(TGA)

CAS Name: Mercaptoacetic acid
Additional Names: thioglycollic acid
Percent Composition: C 26.08%, H 4.38%, O 34.74%, S 34.81%
Literature References: Prepd by the action of sodium sulfhydrate on sodium chloroacetate; by electrolysis of dithioglycollic acid (from sodium sulfide and sodium chloroacetate). Toxicity study: Deichmann, Mergard, J. Ind. Hyg. Toxicol. 30, 373 (1948).

Methiodal Sodium CAS Registry Number: 126-31-8 磺甲磺钠

CAS Name: Iodomethanesulfonic acid sodium salt
Additional Names: sodium iodomethanesulfonate
Trademarks: Skiodan (Winthrop); Abrodil (Schering); Radiographol; Segosin; Diagnorenol
Percent...
Literature References: Prepd by the action of sodium sulfite on methylene iodide at 70° in water-alcohol soln: Ossenbeck et al., US 1842626 (1932 to Winthrop); from iodoform + sodium sulfite: Allardt, US 1867793 (1932 to Schering-Kahlbaum AG).

Mercuric Sodium p-Phenolsulfonate CAS Registry Number: 535-55-7

Additional Names: Mercury and sodium phenolsulfonate; mercuriphenoldisulfonate sodium
Trademarks: Hermophényl
Percent Composition: C 24.39%, H 1.36%, Hg 33.95%, Na 7.78%, O 21.66%, S 10.85%
Literature References: Prepd by the action of the sodium salt of p-phenolsulfonic acid on yellow mercuric oxide: Lumière, Chevrottier, Compt. Rend. 132, 145 (1901); Lumière, Perrin, Pharmacie 1, 102 (1943). The commercial product is a mixture of the monosulfonate (80%) and the disulfonate.

Nikethamide CAS Registry Number: 59-26-7 尼可刹米

CAS Name: N,N-Diethyl-3-pyridinecarboxamide
Additional Names: N,N-diethylnicotinamide; pyridine-3-carboxylic acid diethylamide; nicotinic acid diethylamide
Trademarks: Anacardone; Astrocar; ...
Literature References: Prepd by the action of thionyl chloride on nicotinic acid, followed by treatment with diethylamine hydrochloride; also formed by heating nicotinic acid or quinolinic acid anhydride with diethylamine: Hartmann, Seiberth, US 1403117 (1922); from nicotinic acid + benzenesulfonyldiethyl amide: Oxley et al., J. Chem. Soc. 1946, 763. Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

Pentabromoacetone CAS Registry Number: 79-49-2 五溴丙酮

CAS Name: 1,1,1,3,3-Pentabromo-2-propanone
Percent Composition: C 7.96%, H 0.22%, Br 88.28%, O 3.54%
Literature References: Prepd by the addition of 12 parts bromine to 1 part acetone: Mulder, Jahresber. Fortschr. Chem. 1864, 330.

Hydrocarbostyril CAS Registry Number: 553-03-7 3,4-二氢-2(1H)-喹啉酮

CAS Name: 3,4-Dihydro-2(1H)-quinolinone
Additional Names: 3,4-dihydrocarbostyril; 3,4-dihydro-2-quinolinol; o-aminohydrocinnamic acid lactam; 2-oxo-1,2,3,4-tetrahydroquinoline; dihydro-a-quinol...
Literature References: Prepd by the catalytic reduction of o-nitrocinnamic acid: Blout, Silverman, J. Am. Chem. Soc. 66, 1442 (1944).

Isoladol CAS Registry Number: 530-34-7 2-氨基-1,2-二(4-甲氧基苯基)乙醇

CAS Name: b-Amino-4-methoxy-a-(4-methoxyphenyl)benzeneethanol
Additional Names: 2-amino-1,2-bis(p-methoxyphenyl)ethanol; isodianisylethanolamine; di-p-methoxyphenylhydroxyethylamine
Trademar...
Literature References: Prepd by the condensation of anisaldehyde and glycine: Read, Campbell, J. Chem. Soc. 1930, 2676; Lespagnol, Pharmacie Chimique (Paris, 3rd ed., 1950) p 695.