其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Beclamide CAS Registry Number: 501-68-8 氯丙酰苄胺

CAS Name: 3-Chloro-N-(phenylmethyl)propanamide
Additional Names: N-benzyl-3-chloropropionamide; N-benzyl-b-chloropropanamide; benzchlorpropamide; chloroethylphenamide
Trademarks: Neuracen (B...
Literature References: Prepd by the action of b-chloropropionyl chloride on benzylamine in cooled water at pH 8: Cassell, Kushner, US 2569288 (1951 to Am. Cyanamid); Kushner et al., J. Org. Chem. 16, 1283 (1951).

Bromthymol Blue CAS Registry Number: 76-59-5 溴百里香酚蓝(BTB)

CAS Name: 4,4'-(3H-2,1-Benzoxathiol-3-ylidene)bis[2-bromo-3-methyl-6-(1-methylethyl)phenol] S,S-dioxide
Additional Names: a,a-bis(6-bromo-5-hydroxycarvacryl)-a-hydroxy-o-toluenesulfonic acid g-...
Literature References: Prepd by the action of bromine on thymol blue in glacial acetic acid: Clark, Lubs, J. Wash. Acad. Sci. 5, 609 (1915); 6, 482 (1916); Chem. Zentralbl. 1916, I, 175; II, 1068. See also ref under Bromcresol Green.

Cethexonium Bromide CAS Registry Number: 1794-74-7 西塞溴铵

CAS Name: N-Hexadecyl-2-hydroxy-N,N-dimethylcyclohexanaminium bromide
Additional Names: hexadecyl(2-hydroxycyclohexyl)dimethylammonium bromide; cetyldimethyl(2-hydroxycyclohexyl)ammonium bromid...
Literature References: Prepd by the action of cetyl bromide upon 2-dimethylaminocyclohexanol: Mousseron et al., Bull. Soc. Chim. Biol. 33, 369 (1951).

a , a , b -Trichloro-n-butyraldehyde CAS Registry Number: 76-36-8 2,2,3-三氯丁醛

CAS Name: 2,2,3-Trichlorobutanal
Additional Names: butylchloral; anhydr butylchloral; butyrchloral; crotonchloral
Percent Composition: C 27.38%, H 2.87%, Cl 60.62%, O 9.12%
Literature References: Prepd by the action of chlorine on acetaldehyde: Krämer, Pinner, Ber. 3, 883 (1870); Pinner, Ann. 179, 24 (1875); on paraldehyde: idem; on crotonaldehyde after saturation with gaseous HCl: High, US 2280290 (1942); Brown, Plump, US 2351000 (1944). From crotonaldehyde and chlorine: Ropp et al., Org. Synth. coll. vol. IV, 130 (1963).

p-Nitrobenzyl Cyanide CAS Registry Number: 555-21-5 4-硝基苯乙腈

CAS Name: 4-Nitrobenzeneacetonitrile
Additional Names: p-nitrophenylacetonitrile; p-nitro-a-tolunitrile
Percent Composition: C 59.26%, H 3.73%, N 17.28%, O 19.73%
Literature References: Prepd by the action of concd nitric acid on benzyl cyanide: Robertson, Org. Synth. 2, 57 (1922).

Salicyl Alcohol CAS Registry Number: 90-01-7 2-羟基苄醇

CAS Name: 2-Hydroxybenzenemethanol
Additional Names: saligenin; saligenol; o-hydroxybenzyl alcohol
Percent Composition: C 67.73%, H 6.50%, O 25.78%
Literature References: Prepd by the action of emulsin on salicin; by heating phenol with methylene chloride and aq NaOH.

Fluorine Nitrate CAS Registry Number: 7789-26-6

CAS Name: Nitroxy fluoride
Additional Names: nitrogen trioxyfluoride; nitryl hypofluorite
Percent Composition: F 23.45%, N 17.29%, O 59.26%
Literature References: Prepd by the action of fluorine on nitric acid: Cady, J. Am. Chem. Soc. 56, 2635 (1934); Ruff, Kwasnik, Angew. Chem. 48, 238 (1935); Kwasnik in Handbook of Preparative Inorganic Chemistry vol. 1, G. Brauer, Ed. (Academic Press, New York, 2nd ed., 1963) pp 187-189. Reviews: Kemmitt, Sharp, Adv. Fluorine Chem. 4, 216-218 (1965); Woolf, ibid. 5, 1-30 (1965); Schmutzler, Angew. Chem. Int. Ed. 7, 440-455 (1968).

Amanozine CAS Registry Number: 537-17-7 阿马诺嗪

CAS Name: N-Phenyl-1,3,5-triazine-2,4-diamine
Additional Names: 2-amino-4-anilino-s-triazine; 4-amino-2-anilino-1,3,5-triazine; 2-amino-6-anilino-s-triazine; N-phenylformoguanamineTrademarks: U...
Literature References: Prepd by the action of formic acid on phenylbiguanide: Papini, Folena, Gazz. Chim. Ital. 80, 837 (1950); AT 168063 (1951 to Gedeon Richter), C.A. 47, 8097h (1953); from phenylbiguanide and ethyl formate in methanol in 67% yield: Overberger, Shapiro, J. Am. Chem. Soc. 76, 93 (1954).

Acetonedicarboxylic Acid CAS Registry Number: 542-05-2 1,3-丙酮二羧酸

CAS Name: 3-Oxopentanedioic acid
Additional Names: 3-oxoglutaric acid; b-ketoglutaric acid
Percent Composition: C 41.10%, H 4.14%, O 54.75%
Literature References: Prepd by the action of fuming sulfuric acid on citric acid: Willstätter, Pfannenstiel, Ann. 422, 5 (1921); Ingold, Nickolls, J. Chem. Soc. 121, 1642 (1922); R. Adams et al., Org. Synth. coll. vol. I, 10 (2nd ed., 1941). By the action of Aspergillus niger on ammonium citrate mixed with some citric acid: Walker et al., J. Chem. Soc. 1927, 3050; also by B. pyocyaneus: Butterworth, Walker, Biochem. J. 23, 931 (1929). Decomposition studies: Wiig, J. Phys. Chem. 32, 961 (1928). Intermediate in synthesis of tropinone: R. Robinson, J. Chem. Soc. 111, 762 (1917); C. Schöpf, G. Lehmann, Ann. 518, 1 (1921).

Celestin Blue CAS Registry Number: 1562-90-9 天青石蓝

CAS Name: 1-(Aminocarbonyl)-7-(diethylamino)-3,4-dihydroxyphenoxazin-5-ium chloride
Additional Names: 1-carbamoyl-7-(diethylamino)-3,4-dihydroxyphenazoxonium chloride; C.I. Mordant Blue 14; C.I...
Literature References: Prepd by the action of gallamide on N,N-diethyl-p-nitrosoaniline HCl: Gnehm, Bauer, J. Prakt. Chem. 72, 249 (1905); Grandmougin, Bodmer, ibid. 77, 502 (1908). See also: US 534809 (1895); US 1227407 (1917); Colour Index vol. 4 (3rd ed., 1971). Review: H. J. Conn's Biological Stains, R. D. Lillie, Ed. (Williams Wilkins, Baltimore, 9th ed., 1977) pp 407-408.