其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Isonipecotic Acid CAS Registry Number: 498-94-2 4-哌啶甲酸

CAS Name: 4-Piperidinecarboxylic acid
Additional Names: hexahydroisonicotinic acid
Percent Composition: C 55.79%, H 8.58%, N 10.84%, O 24.77%
Literature References: Prepd by reduction of isonicotinic acid in glacial acetic acid in the presence of platinum oxide: Wibaut, Rec. Trav. Chim. 63, 141 (1944); by reduction of isonicotinic acid in H2O and concd HCl with PtO2: Sperber et al., US 2739968 (1956 to Schering); Freifelder, US 3159639 (1964 to Abbott).

Styrene Glycol CAS Registry Number: 93-56-1 (±)-1-苯基-1,2-乙二醇

CAS Name: 1-Phenyl-1,2-ethanediol
Additional Names: phenylglycol; phenylethyleneglycol; a,b-dihydroxyethylbenzene
Percent Composition: C 69.55%, H 7.30%, O 23.16%
Literature References: Prepd by reduction of phenylglyoxylic acid with LiAlH4: Nystrom, Brown, J. Am. Chem. Soc. 69, 2548 (1947); by reduction of styrene peroxide: Russel, J. Am. Chem. Soc. 75, 5011 (1953). Prepn of optically active styrene glycol: Wilhelm, Bright, Helv. Chim. Acta 37, 221 (1954).

p-Toluenesulfinic Acid CAS Registry Number: 536-57-2 对甲苯亚磺酸

Percent Composition: C 53.83%, H 5.16%, O 20.49%, S 20.53%
Literature References: Prepd by reduction of p-toluenesulfonyl chloride with zinc dust: Whitmore, Hamilton, Org. Synth. 2, 89 (1922). Because the sulfinic acid is difficult to dry without partial conversion to the sulfonic acid, the sodium salt, CH3C6H4SO2Na.2H2O, is usually prepd. The free sulfinic acid is then obtained as needed by dissolving the sodium salt in cold water and carefully acidifying the soln with the exact amt of HCl needed.

Dihydrothebaine CAS Registry Number: 561-25-1

CAS Name: (5a)-6,7-Didehydro-4,5-epoxy-3,6-dimethoxy-17-methylmorphinan
Percent Composition: C 72.82%, H 7.40%, N 4.47%, O 15.32%
Literature References: Prepd by reduction of thebaine: Small et al., J. Am. Chem. Soc. 58, 1457 (1936); K. W. Bentley, The Chemistry of the Morphine Alkaloids (Oxford, 1954) p 204.

n-Amylamine CAS Registry Number: 110-58-7 1-氨基戊烷

CAS Name: 1-Pentanamine
Additional Names: pentylamine; 1-aminopentane
Percent Composition: C 68.90%, H 15.03%, N 16.07%
Literature References: Prepd by reduction of valeronitrile with LiAlH4 and with LiAlH4-AlCl3: Nystrom, J. Am. Chem. Soc. 77, 2544 (1955).

Nitrin CAS Registry Number: 553-74-2 2-((2-苯基肼基)甲基)苯胺

CAS Name: 2-Aminobenzaldehyde phenylhydrazone
Percent Composition: C 73.91%, H 6.20%, N 19.89%
Literature References: Prepd by refluxing 2-nitrobenzaldehyde with phenylhydrazine: Knöpfer, Monatsh. Chem. 31, 97 (1910).

S-Benzylthiuronium Chloride CAS Registry Number: 538-28-3 S-苄基硫脲盐酸盐

CAS Name: Carbamimidothioic acid phenylmethyl ester monohydrochloride
Percent Composition: C 47.40%, H 5.47%, Cl 17.49%, N 13.82%, S 15.82%
Literature References: Prepd by refluxing a mixture of 126 g benzyl chloride, 76 g thiourea, and 200 ml alcohol for 0.5 hr: Donleavy, J. Am. Chem. Soc. 58, 1004 (1936).

Glucosulfone Sodium CAS Registry Number: 554-18-7 葡胺苯砜

CAS Name: 1,1'-[Sulfonylbis(4,1-phenyleneimino)]bis[1-deoxy-1-sulfo-D-glucitol] disodium salt
Additional Names: p,p'-sulfonyldianiline N,N'-diglucoside disodium disulfonate; p,p'-sulfonyldianil...
Literature References: Prepd by refluxing a mixture of 4,4¢-diaminodiphenylsulfone, glucose, sodium bisulfite, and 80% ethanol: CH 234108 (1944 to B. Siegfried), C.A. 43, 4297a (1949); B. C. Jain et al., Sci. Cult. 11, 568 (1946). Structure activity study: W. Logemann, G. P. Miori, Arzneim.-Forsch. 5, 213 (1955). Clinical evaluation in ocular leprosy: A. Bouzas, Arch. Ophthalmol. 31, 629 (1971).

Benzoyl Isothiocyanate CAS Registry Number: 532-55-8 苯甲酰基异硫氰酸酯

Additional Names: Benzoylthiocarbimide
Percent Composition: C 58.88%, H 3.09%, N 8.58%, O 9.80%, S 19.65%
Literature References: Prepd by refluxing a mixture of KSCN and benzoyl chloride in benzene at 110-120°: Ambelang, Johnson, J. Am. Chem. Soc. 61, 632 (1939). From NH3SCN, acetone and benzoyl chloride: Frank, Smith, Org. Synth. 28, 89 (1948).

n-Butyl Sulfide CAS Registry Number: 544-40-1 二丁基硫醚

CAS Name: 1,1'-Thiobisbutane
Additional Names: butylthiobutane; dibutyl sulfide
Percent Composition: C 65.68%, H 12.40%, S 21.92%
Literature References: Prepd by refluxing a soln contg sodium sulfide and sodium n-butyl sulfate for several hrs: Gray, Gutekunst, J. Am. Chem. Soc. 42, 856 (1920).