其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Heptanal Sodium Bisulfite CAS Registry Number: 13495-04-0 钠1-羟基-1-庚烷磺酸酯

CAS Name: 1-Hydroxy-1-heptanesulfonic acid monosodium salt
Additional Names: heptaldehyde sodium bisulfite
Trademarks: Hepbisul
Percent Composition: C 38.52%, H 6.93%, Na 10.53%, O 29.32%...
Literature References: Prepd by shaking a 30% ether soln of heptanal with an excess of 40% aq sodium bisulfite. Soln: Garay, US 3019161 (1962 to Baker Castor Oil Co., compd and method not claimed). General method of prepn: Lauer, Langkammerer, J. Am. Chem. Soc. 57, 2360 (1935).

Diacetoneglucose CAS Registry Number: 582-52-5 双丙酮葡萄糖

CAS Name: 1,2:5,6-Bis-O-(1-methylethylidene)-D-glucofuranose
Additional Names: 1,2:5,6-diisopropylidene-D-glucose; 1,2:5,6-diisopropylidene-D-glucofuranose
Percent Composition: C 55.37%, H 7...
Literature References: Prepd by shaking glucose wih acetone contg 1% HCl: Fischer, Rund, Ber. 49, 90, 93 (1916). Improved procedure (90% yield) using 85% H3PO4 and anhydr ZnCl2 in a mechanically stirred suspension of glucose in acetone: Glen et al., US 2715121 (1955 to Am. Home Prod.).

tert-Butyl Chloride CAS Registry Number: 507-20-0 氯代叔丁烷

CAS Name: 2-Chloro-2-methylpropane
Additional Names: 2-chloroisobutane; trimethylchloromethane
Percent Composition: C 51.90%, H 9.80%, Cl 38.30%
Literature References: Prepd by shaking tert-butyl alcohol with concd HCl and distilling: Norris, Olmsted, Org. Synth. 8, 50 (1928). Prepn from tert-butyl alcohol and PCl3: Gerrard et al., J. Chem. Soc. 1953, 1920.

Samarium Cobalt CAS Registry Number: 12017-68-4 钴钐合金粉

CAS Name: Cobalt compd with samarium (5:1)
Additional Names: samarium pentacobalt
Percent Composition: Co 66.21%, Sm 33.79%
Literature References: Prepd by sintering or mechanical alloying to yield a single phase, highly efficient permanent magnetic material. Prepn: K. J. Strnat, A. E. Ray, Z. Metallkunde 61, 461 (1970). Synthesis by mechanical alloying: J. Wecker et al., J. Appl. Phys. 69, 6058 (1991). Prepn and magnetic properties of nanoparticles: E. M. Kirkpatrick et al., IEEE Trans. Magnetics 32, 4502 (1996). Studies on use as a dental material: H. Tsutsui et al., J. Dent. Res. 58, 1597 (1979). Biocompatibility study: L. Bondemark et al., Am. J. Orthod. Dentofac. Orthop. 105, 568 (1994). Review of magnetic properties: R. A. McCurrie, Cobalt 1, 23-24, 28 (1973); of properties, production and applications: H. J. Marik, K. Schlenk, Powder Metallurgy Int. 9, 142-144 (1977).

D -Gulose CAS Registry Number: 4205-23-6 (2R,3R,4S,5R)-2,3,4,5,6-五羟基己醛

Percent Composition: C 40.00%, H 6.71%, O 53.28%
Literature References: Prepd by sodium amalgam reduction of an acid soln of the g-lactone of D-gulonic acid: Fischer, Stahel, Ber. 24, 532 (1891); van Ekenstein, Blanksma, Rec. Trav. Chim. 27, 3 (1908). Alternate synthesis: Meyer zu Reckendorf, Angew. Chem. Int. Ed. 6, 177 (1967); idem, Methods Carbohydr. Chem. 6, 129 (1972); R. Köster et al., Angew. Chem. Int. Ed. 19, 547 (1980).

L -Gulose CAS Registry Number: 6027-89-0 L-(+)-古洛糖

Percent Composition: C 40.00%, H 6.71%, O 53.28%
Literature References: Prepd by sodium amalgam reduction of an acid soln of the g-lactone of L-gulonic acid: Fischer, Piloty, Ber. 24, 526 (1891). See also van Ekenstein, Blanksma, Rec. Trav. Chim. 27, 3 (1908); Levene, LaForge, J. Biol. Chem. 20, 430 (1915); Talen, Rec. Trav. Chim. 44, 891 (1925); Isbell, J. Am. Chem. Soc. 55, 2167 (1933). Synthesis from D-mannose: Evans, Parrish, Carbohydr. Res. 28, 359 (1973); from D-glucose: D. K. Minster, S. M. Hecht, J. Org. Chem. 43, 3987 (1978).

p-Bromoaniline CAS Registry Number: 106-40-1 对溴苯胺

CAS Name: 4-Bromobenzeneamine
Additional Names: 4-bromoaniline
Percent Composition: C 41.89%, H 3.52%, Br 46.45%, N 8.14%
Literature References: Prepd by steam distilling sodium hydroxide and p-bromoacetanilide: Scott, J. Chem. Soc. 123, 3199 (1923); by direct bromination of aniline: Kosolapoff, J. Am. Chem. Soc. 75, 3596 (1953).

Triamcinolone Acetonide CAS Registry Number: 76-25-5 曲安奈德

CAS Name: (11b,16a)-9-Fluoro-11,21-dihydroxy-16,17-[1-methylethylidenebis(oxy)]pregna-1,4-diene-3,20-dione
Additional Names: 9a-fluoro-11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cycl...
Literature References: Prepd by stirring a suspension of triamcinolone in acetone in the presence of a trace of perchloric acid: Fried et al., J. Am. Chem. Soc. 80, 2338 (1958); Bernstein et al., ibid. 81, 1689 (1959); Bernstein, Allen, US 2990401 (1961 to Am. Cyanamid). Alternate synthesis using 2,3-dibromo-5,6-dicyanoquinone: Hydorn, US 3035050 (1962 to Olin Mathieson). Clinical trial in chronic asthma: I. L. Bernstein et al., Chest 81, 20 (1982). Comprehensive description: K. Florey, Anal. Profiles Drug Subs. 1, 397-421 (1972); D. H. Sieh, ibid. 11, 615-649 (1982).

Trimellitic Anhydride CAS Registry Number: 552-30-7 偏苯三酸酐

CAS Name: 1,3-Dihydro-1,3-dioxo-5-isobenzofurancarboxylic acid
Additional Names: trimellitic acid 1,2-anhydride; anhydrotrimellitic acid; 1,3-dioxo-5-phthalancarboxylic acid
Percent Composit...
Literature References: Prepd by subliming trimellitic acid above its mp: Alder, Dortmann, Ber. 85, 556 (1952); by heating crude trimellitic acid with V2O5: McKinnis, US 2998431 (1959 to Union Oil of Calif.).

Badische Acid CAS Registry Number: 86-60-2 7-氨基萘-1磺酸

CAS Name: 7-Amino-1-naphthalenesulfonic acid
Additional Names: 2-naphthylamine-8-sulfonic acid
Percent Composition: C 53.80%, H 4.06%, N 6.27%, O 21.50%, S 14.36%
Literature References: Prepd by sulfonation of 2-naphthylamine: Green, Vakil, J. Chem. Soc. 113, 35 (1918); Hennion, Schmidle, J. Am. Chem. Soc. 65, 2468 (1943).