其它产品项目整合

项目整合的本质是一项集合成方法学、反应工程学与过程分析技术于一体的系统工程。其核心逻辑可以概括为以下几点：源头优选：利用如N-硝胺化学等底层方法学突破，从分子层面颠覆传统高成本、高污染路线。过程强化：依托连续流技术，攻克有机金属试剂应用、光化学反应放大等“不可能”任务，实现高危工艺的本质安全。系统集成：整合“反应-淬灭-分离”全流程，利用微流控与在线分析技术，消除批次间的差异，实现药品制造的连续化与智能化。当前，中间体工艺研发正在经历从“经验驱动”向“数据驱动”的转变。AI辅助路线设计、自动化高通量筛选与连续制造平台的结合，将使得“分子结构与最优工艺路径”之间的映射关系逐渐清晰。未来的竞争优势，将属于那些能够将底层化学创新与先进工程技术进行无缝整合的研发体系。
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其它产品项目整合

Succinylcholine Iodide CAS Registry Number: 541-19-5 碘化O,O-琥珀酰

Additional Names: O,O-Succinyldicholine iodide; diacetylcholine iodide; diacetylcholine diiodide; suxamethonium iodide; bis(b-dimethylaminoethyl)succinate bis(methyl iodide)
Trademarks: Celocur...
Literature References: Prepd by reacting b-bromoethyl succinate with trimethylamine: Glick, J. Biol. Chem. 137, 357 (1941); Fusco et al., Gazz. Chim. Ital. 79, 129, 837 (1949); Walker, J. Chem. Soc. 1950, 193. Succinic acid chloride may be coupled with choline chloride directly or with dimethylaminoethanol, followed by quaternization with methyl iodide: Tammelin, Acta Chem. Scand. 7, 185 (1953). A third method is to start with the diethyl ester of succinic acid, then bring about the exchange reaction with dimethylaminoethanol, and quaternize with methyl iodide: Phillips, J. Am. Chem. Soc. 71, 3264 (1949).

Potassium Hexacyanocobaltate(III) CAS Registry Number: 13963-58-1 钴氰化钾

CAS Name: Tripotassium hexakis(cyano-C)cobaltate(3-)
Additional Names: potassium cyanocobaltate(III); potassium cobalticyanide; potassium cobaltihexacyanide; cobalt potassium cyanide
Percent...
Literature References: Prepd by reacting cobalt acetate or cyanide with potassium cyanide, followed by air-oxidation of the cobaltocyanide formed: Biltz, Biltz, Z. Anorg. Allg. Chem. 50, 108 (1906); Grube, Z. Elektrochem. 32, 561 (1926); Benedetti-Pichler, Z. Anal. Chem. 70, 258 (1927); Bigelow, Inorg. Synth. 2, 225 (1946).

tert-Butyl Chloroacetate CAS Registry Number: 107-59-5 氯乙酸叔丁酯

CAS Name: Chloroacetic acid 1,1-dimethyl ester
Additional Names: t-butyl chloroacetate; chloroacetic acid tert-butyl ester
Percent Composition: C 47.85%, H 7.36%, Cl 23.54%, O 21.25%
Literature References: Prepd by reacting monochloroacetic acid and isobutylene in dioxane in the presence of sulfuric acid: Johnson et al., J. Am. Chem. Soc. 75, 4995 (1953); from tert-butyl alcohol, chloroacetyl chloride and dimethylaniline: Baker, Org. Synth. 24, 21 (1944).

o-Tolualdehyde CAS Registry Number: 529-20-4 邻甲基苯甲醛

CAS Name: 2-Methylbenzaldehyde
Additional Names: o-toluylaldehyde
Percent Composition: C 79.97%, H 6.71%, O 13.32%
Literature References: Prepd by reacting nitropropane with o-xylyl bromide in the presence of sodium ethanoate: Hass, Bender, Org. Synth. 30, 99 (1950).

o-Toluamide CAS Registry Number: 527-85-5 2-甲基苯甲酰胺

CAS Name: 2-Methylbenzamide
Percent Composition: C 71.09%, H 6.71%, N 10.36%, O 11.84%
Literature References: Prepd by reacting o-tolunitrile, hydrogen peroxide, 95% alcohol, and sodium hydroxide at 40-50°: Noller, Org. Synth. coll. vol. II, 586 (1943). Also prepared by reacting the nitrile with boron fluoride in dil acetic acid: Hauser, Hoffenberg, J. Org. Chem. 20, 1448 (1955).

Monuron CAS Registry Number: 150-68-5 1,1-二甲基-3-(对氯苯基)脲

CAS Name: N'-(4-Chlorophenyl)-N,N-dimethylurea
Additional Names: 1,1-dimethyl-3-(p-chlorophenyl)urea; CMU
Trademarks: Karmex Monuron Herbicide; Telvar (DuPont)
Percent Composition: C 54.4...
Literature References: Prepd by reacting p-chlorophenyl isocyanate with dimethylamine: Bucha, Todd, Science 114, 493 (1951); see also US 2655444; US 2655445; US 2655446; US 2655447. Toxicity study: G. W. Bailey, J. L. White, Residue Rev. 10, 97 (1965). Review: McCall, Agric. Chem. 7, 40 (1952).

Bietamiverine CAS Registry Number: 479-81-2 苯哌乙胺酯

CAS Name: a-Phenyl-1-piperidineacetic acid 2-(diethylamino)ethyl ester
Additional Names: b-diethylaminoethyl phenylpiperidinoacetate; b-diethylaminoethyl a-(1-piperidyl)phenylacetate
Percent...
Literature References: Prepd by reacting piperidine with phenylchloroacetic acid ethyl ester in chloroform: Reetz, DE 859892 (1952 to Nordmark-Werke); from b-diethylaminoethyl phenylbromoacetate and piperidine in chloroform: Blicke et al., J. Am. Chem. Soc. 76, 3161 (1954); from ethyl a-(1-piperidyl)phenylacetate and b-diethylaminoethyl chloride: Moffett, Hart, J. Am. Pharm. Assoc. Sci. Ed. 42, 717 (1953). Clinical tests: Ciravegna et al., Clin. Ter. 57, 227 (1971).

Aluminon CAS Registry Number: 569-58-4 玫瑰红三羧酸铵

CAS Name: 5-[(3-Carboxy-4-hydroxyphenyl)(3-carboxy-4-oxo-2,5-cylohexadien-1-ylidene)methyl]-2-hydroxybenzoic acid triammonium salt
Additional Names: 3-[bis(3-carboxy-4-hydroxyphenyl)methylene]-...
Literature References: Prepd by reacting sodium nitrite with salicylic acid and adding formaldehyde, then treating with ammonia: G. B. Heisig, W. M. Lauer, Org. Synth. coll. vol. I, 54 (2nd ed., 1941).

Chlorotrianisene CAS Registry Number: 569-57-3 氯烯雌醚

CAS Name: 1,1',1''-(1-Chloro-1-ethenyl-2-ylidene)tris[4-methoxybenzene]
Additional Names: chlorotris(p-methoxyphenyl)ethylene; tri-p-anisylchloroethylene; tris(p-methoxyphenyl)chloroethylene Literature References: Prepd by reacting tri-p-anisylethylene or tri-p-anisylethanol with Cl in an inert solvent: Basford and I.C.I., GB 561508 (1944). Synthesis from p-(p-anisoyl)anisole: Shelton, Van Campen, Jr., US 2430891 (1947 to Merrell).

Amphetaminil CAS Registry Number: 17590-01-1 安非他尼

CAS Name: a-[(1-Methyl-2-phenylethyl)amino]benzeneacetonitrile
Additional Names: N-(a-methylphenethyl)-2-phenylglycinonitrile; a-phenyl-a-(b-phenylisopropylamino)acetonitrile; a-phenyl-a-(1-met...
Literature References: Prepd by reaction of DL-b-phenylisopropylamine with sodium cyanide and benzaldehyde or with a-phenyl-a-bromoacetonitrile: Klosa, DE 1112987 (1959), C.A. 56, 3409d (1962); idem, J. Prakt. Chem. 20, 275 (1963). Pharmacology: Dominok, Oelssner, Acta Biol. Med. Ger. 20, 625 (1968); Beyer et al., Dtsch. Apoth. Ztg. 111, 677, 680 (1971). Metabolic studies: Remberg et al., Arch. Toxicol. 29, 153 (1972). Chemistry: Beyrich et al., Pharmazie 27, 28 (1972); Gloeckl, Beyrich, ibid. 95.